β-肾上腺受体阻滞剂的水生态毒理学研究进展

彭祖华; 池剑; 孙立伟; 傅正伟

doi:10.7524/AJE.1673-5897.20120608001

生态毒理学报

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彭祖华, 池剑, 孙立伟, 傅正伟. β-肾上腺受体阻滞剂的水生态毒理学研究进展[J]. 生态毒理学报, 2013, 8(4): 494-503. doi: 10.7524/AJE.1673-5897.20120608001

引用本文:

彭祖华, 池剑, 孙立伟, 傅正伟. β-肾上腺受体阻滞剂的水生态毒理学研究进展[J]. 生态毒理学报, 2013, 8(4): 494-503. doi: 10.7524/AJE.1673-5897.20120608001

Peng Zuhua, Chi Jian, Sun Liwei, Fu Zhengwei. Current Progress in the Aquatic Ecotoxicology ofβ-adrenergic Receptor Blockers[J]. Asian journal of ecotoxicology, 2013, 8(4): 494-503. doi: 10.7524/AJE.1673-5897.20120608001

Citation:

Peng Zuhua, Chi Jian, Sun Liwei, Fu Zhengwei. Current Progress in the Aquatic Ecotoxicology ofβ-adrenergic Receptor Blockers[J]. Asian journal of ecotoxicology, 2013, 8(4): 494-503. doi: 10.7524/AJE.1673-5897.20120608001

β-肾上腺受体阻滞剂的水生态毒理学研究进展

浙江工业大学生物与环境工程学院, 杭州 310032

作者简介: 彭祖华(1987-),男,硕士,研究方向为水生态毒理学,E-mail:pengzh1015@yahoo.com.cn

基金项目:
国家自然科学基金(20907044)
中图分类号: X171.5

Current Progress in the Aquatic Ecotoxicology ofβ-adrenergic Receptor Blockers

College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032
Fund Project:

摘要: β-肾上腺受体阻滞剂是一类治疗心血管疾病的药物,其药理作用是和β-肾上腺受体结合但不使其活化。由于此类化合物在环境水体中的高检出率以及自身所具有的生物活性,近年来有关其对非靶生物的生态毒性效应日益受到关注。在概括了β-受体阻滞剂的使用现状及其在水体环境中的归趋后,重点介绍了此类化合物对鱼类以及其他水生生物的毒性效应。最后,针对目前的研究现状对今后的工作做出展望。
- 药品和个人护理品 /
- 环境行为 /
- 肾上腺受体 /
- 水生生物 /
- 风险评价
Abstract: β-adrenergic receptor blockers (or β-blockers) as a group of pharmaceuticals are mostly used in the treatment of cardiovascular disorders. The pharmacological mechanism of β-blockers is that they bind to the β-adrenergic receptors and do not cause receptors activation or stimulation. Since the β-blockers are widely detected in the aquatic environment and have biological activity, the ecotoxicological effects of these pharmaceuticals on non-target organisms have received increased attention in recent years. In this article, we generalized the current applications and fates of β-blockers in the aquatic environment, and then focused on the toxic effects of these compounds on fish as well as other aquatic organisms. Finally, based on the current experimental data, the prospects for further researches on the β-blockers were discussed.
- pharmaceuticals and personal care products(PPCPs) /
- environmental behavior /
- adrenergic receptor /
- aquatic organism /
- risk assessment

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彭祖华, 池剑, 孙立伟, 傅正伟. β-肾上腺受体阻滞剂的水生态毒理学研究进展[J]. 生态毒理学报, 2013, 8(4): 494-503. doi: 10.7524/AJE.1673-5897.20120608001

引用本文:

彭祖华, 池剑, 孙立伟, 傅正伟. β-肾上腺受体阻滞剂的水生态毒理学研究进展[J]. 生态毒理学报, 2013, 8(4): 494-503. doi: 10.7524/AJE.1673-5897.20120608001

Citation:

β-肾上腺受体阻滞剂的水生态毒理学研究进展

作者简介: 彭祖华(1987-),男,硕士,研究方向为水生态毒理学,E-mail:pengzh1015@yahoo.com.cn
浙江工业大学生物与环境工程学院, 杭州 310032

收稿日期: 2012-06-08

基金项目:

国家自然科学基金(20907044)

关键词:

摘要: β-肾上腺受体阻滞剂是一类治疗心血管疾病的药物,其药理作用是和β-肾上腺受体结合但不使其活化。由于此类化合物在环境水体中的高检出率以及自身所具有的生物活性,近年来有关其对非靶生物的生态毒性效应日益受到关注。在概括了β-受体阻滞剂的使用现状及其在水体环境中的归趋后,重点介绍了此类化合物对鱼类以及其他水生生物的毒性效应。最后,针对目前的研究现状对今后的工作做出展望。

English Abstract

Current Progress in the Aquatic Ecotoxicology ofβ-adrenergic Receptor Blockers

College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032

Received Date: 2012-06-08

Fund Project:

Keywords:

pharmaceuticals and personal care products(PPCPs) /
environmental behavior /
adrenergic receptor /
aquatic organism /
risk assessment

Abstract: β-adrenergic receptor blockers (or β-blockers) as a group of pharmaceuticals are mostly used in the treatment of cardiovascular disorders. The pharmacological mechanism of β-blockers is that they bind to the β-adrenergic receptors and do not cause receptors activation or stimulation. Since the β-blockers are widely detected in the aquatic environment and have biological activity, the ecotoxicological effects of these pharmaceuticals on non-target organisms have received increased attention in recent years. In this article, we generalized the current applications and fates of β-blockers in the aquatic environment, and then focused on the toxic effects of these compounds on fish as well as other aquatic organisms. Finally, based on the current experimental data, the prospects for further researches on the β-blockers were discussed.