NMR代谢组学在水生软体动物生态毒理研究中的应用
Application of NMR-based Metabolomics in the Study of Ecotoxicology of Molluscs: A Review
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摘要: 随着核磁共振(NMR)技术的不断发展,基于NMR的代谢组学方法已经逐渐成为研究水生动物在代谢水平响应环境变化的一种有效方法。水生软体动物作为重要的环境监测生物,近年来人们在其相关研究中取得了不小的成果。文章总结了利用NMR的代谢组学方法研究各类环境胁迫因子对水生软体动物代谢影响的成果,主要综述了水生软体动物不同组织内代谢物组成和含量对环境胁迫的响应,同时对水生软体动物生态毒理代谢组学研究中存在的问题和今后的发展方向进行了讨论和展望。Abstract: With the development of the nuclear magnetic resonance (NMR) technology, NMR-based metabolomics has gradually become an effective approach for studying the metabolic response of aquatic animals to environmental change. As the sensitive species, aquatic molluscs are the important organisms in environmental monitoring, and significant progresses have been made. This paper reviewed the research progresses on the metabolic aspects of various environmental contaminants or stressors in aquatic molluscs based on NMR metabolomics technology, and mainly fouced on the metabolic differences among the various tissues in terms of metabolites and their concentration levels. The shortcomes of recent research and prospective future work on NMR-based metabolomics in aquatic ecotoxicology are also discussed.
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Key words:
- nuclear magnetic resonance /
- aquatic molluscs /
- ecotoxicology /
- metabolomics
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