磺胺类抗生素对不同革兰氏阴性菌的毒物兴奋效应研究

程逸飞; 曾鸿鹄; 于洋; 王大力; 孙昊宇; 林志芬; 莫凌云

doi:10.7524/AJE.1673-5897.20170627001

生态毒理学报

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程逸飞, 曾鸿鹄, 于洋, 王大力, 孙昊宇, 林志芬, 莫凌云. 磺胺类抗生素对不同革兰氏阴性菌的毒物兴奋效应研究[J]. 生态毒理学报, 2018, 13(2): 57-65. doi: 10.7524/AJE.1673-5897.20170627001

引用本文:

Cheng Yifei, Zeng Honghu, Yu Yang, Wang Dali, Sun Haoyu, Lin Zhifen, Mo Lingyun. Study on the Hormesis of Sulfonamides on Different Gram-negative Bacteria[J]. Asian Journal of Ecotoxicology, 2018, 13(2): 57-65. doi: 10.7524/AJE.1673-5897.20170627001

Citation:

Cheng Yifei, Zeng Honghu, Yu Yang, Wang Dali, Sun Haoyu, Lin Zhifen, Mo Lingyun. Study on the Hormesis of Sulfonamides on Different Gram-negative Bacteria[J]. Asian Journal of Ecotoxicology, 2018, 13(2): 57-65. doi: 10.7524/AJE.1673-5897.20170627001

磺胺类抗生素对不同革兰氏阴性菌的毒物兴奋效应研究

1. 桂林理工大学环境科学与工程学院, 桂林 541004;
2. 污染控制与资源化研究国家重点实验室, 同济大学环境科学与工程学院, 上海 200092;
3. 环境保护部固体废物与化学品管理技术中心, 北京 100029

作者简介: 程逸飞(1992-),男,硕士,研究方向为微生物毒理学,E-mail:460358397@qq.com

基金项目:
同济大学污染控制与资源化研究国家重点实验室自主研究(重点)项目(PCRRY16007)；国家自然科学面上基金(21377096,21577105，21777123)；上海市科学技术委员会科研计划课题(14DZ2261100，17DZ1200103)；环境化学与生态毒理学国家重点实验室开放基金课题(KF2016-11)
中图分类号: X171.5

Study on the Hormesis of Sulfonamides on Different Gram-negative Bacteria

1. College of Environmental Science and Engineering, Guilin University of Technology, Guilin 541004, China;
2. State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China;
3. Solid Waste and Chemicals Management Center, Ministry of Environmental Protection, Beijing 100029, China
Fund Project:

摘要: 抗生素滥用所导致的环境问题日益受到人们的关注，抗生素在环境中常以低剂量的形式暴露，生物体在低浓度的抗生素作用下通常会表现出毒物兴奋效应(hormesis)。因此，研究抗生素的hormesis，对抗生素的生态风险评价极其重要。为了研究抗生素的hormesis，本文选取4种磺胺类抗生素为研究对象，观测了不同浓度培养基下磺胺对大肠杆菌能否产生hormesis。结果表明，磺胺对大肠杆菌在原倍和0.8倍浓度的培养基下不产生hormesis，在0.6和0.4倍浓度的培养基下产生hormesis；并且，结合我们之前对另一种革兰氏阴性菌——费氏弧菌hormesis的研究可知，对于具有不同群体感应系统的2种革兰氏阴性菌，都存在hormesis，磺胺可以通过作用群体感应系统使革兰氏阴性菌产生hormesis，只是hormesis的大小不同。上述研究结果为抗生素的生态风险评价提供了依据，为hormesis的相关研究提供了参考。
- 磺胺类抗生素 /
- 大肠杆菌 /
- 费氏弧菌 /
- 群体感应 /
- 毒物兴奋效应
Abstract: The environmental problems caused by the overuse of antibiotics have attracted increasing concern. Antibiotics in the environment are commonly at low concentrations, which is likely to induce hormetic effects on the organisms. Therefore, the study on the hormesis of antibiotics is significantly important to the ecological risk assessment. In this research, four sulfonamides were investigated for their hormetic effects on Escherichia coli under different concentrations of culture medium. The results showed that the sulfonmides induced no hormesis on Escherichia coli in undiluted and 0.8-fold dilution of MH media, whilst obvious hormetic effects in 0.6 and 0.4-fold dilutions of MH media. Moreover, in combination with our previous study on hormesis with another Gram-negative bacterium, Aliivibrio fischeri, it can be inferred that hormesis could occur for both species irrespective of the types of quorum sensing systems. This study provides evidence for the ecological risk assessment of antibiotics, and it provides reference for the related research of hormesis.
- sulfonamide /
- Escherichia coli /
- Aliivibrio fischeri /
- quorum sensing system /
- hormesis

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Citation:

磺胺类抗生素对不同革兰氏阴性菌的毒物兴奋效应研究

作者简介: 程逸飞(1992-),男,硕士,研究方向为微生物毒理学,E-mail:460358397@qq.com
1. 桂林理工大学环境科学与工程学院, 桂林 541004;

2. 污染控制与资源化研究国家重点实验室, 同济大学环境科学与工程学院, 上海 200092;

3. 环境保护部固体废物与化学品管理技术中心, 北京 100029

收稿日期: 2017-06-27

基金项目:

同济大学污染控制与资源化研究国家重点实验室自主研究(重点)项目(PCRRY16007)；国家自然科学面上基金(21377096,21577105，21777123)；上海市科学技术委员会科研计划课题(14DZ2261100，17DZ1200103)；环境化学与生态毒理学国家重点实验室开放基金课题(KF2016-11)

关键词:

摘要: 抗生素滥用所导致的环境问题日益受到人们的关注，抗生素在环境中常以低剂量的形式暴露，生物体在低浓度的抗生素作用下通常会表现出毒物兴奋效应(hormesis)。因此，研究抗生素的hormesis，对抗生素的生态风险评价极其重要。为了研究抗生素的hormesis，本文选取4种磺胺类抗生素为研究对象，观测了不同浓度培养基下磺胺对大肠杆菌能否产生hormesis。结果表明，磺胺对大肠杆菌在原倍和0.8倍浓度的培养基下不产生hormesis，在0.6和0.4倍浓度的培养基下产生hormesis；并且，结合我们之前对另一种革兰氏阴性菌——费氏弧菌hormesis的研究可知，对于具有不同群体感应系统的2种革兰氏阴性菌，都存在hormesis，磺胺可以通过作用群体感应系统使革兰氏阴性菌产生hormesis，只是hormesis的大小不同。上述研究结果为抗生素的生态风险评价提供了依据，为hormesis的相关研究提供了参考。

English Abstract

Study on the Hormesis of Sulfonamides on Different Gram-negative Bacteria

1. College of Environmental Science and Engineering, Guilin University of Technology, Guilin 541004, China;
2. State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China;
3. Solid Waste and Chemicals Management Center, Ministry of Environmental Protection, Beijing 100029, China

Received Date: 2017-06-27

Fund Project:

Keywords:

Abstract: The environmental problems caused by the overuse of antibiotics have attracted increasing concern. Antibiotics in the environment are commonly at low concentrations, which is likely to induce hormetic effects on the organisms. Therefore, the study on the hormesis of antibiotics is significantly important to the ecological risk assessment. In this research, four sulfonamides were investigated for their hormetic effects on Escherichia coli under different concentrations of culture medium. The results showed that the sulfonmides induced no hormesis on Escherichia coli in undiluted and 0.8-fold dilution of MH media, whilst obvious hormetic effects in 0.6 and 0.4-fold dilutions of MH media. Moreover, in combination with our previous study on hormesis with another Gram-negative bacterium, Aliivibrio fischeri, it can be inferred that hormesis could occur for both species irrespective of the types of quorum sensing systems. This study provides evidence for the ecological risk assessment of antibiotics, and it provides reference for the related research of hormesis.

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磺胺类抗生素对不同革兰氏阴性菌的毒物兴奋效应研究

作者简介: 程逸飞(1992-),男,硕士,研究方向为微生物毒理学,E-mail:460358397@qq.com

Study on the Hormesis of Sulfonamides on Different Gram-negative Bacteria

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磺胺类抗生素对不同革兰氏阴性菌的毒物兴奋效应研究

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Study on the Hormesis of Sulfonamides on Different Gram-negative Bacteria

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