环境污染物与肠道菌群互作关系的研究进展
Interaction between Environmental Pollutants and Gut Microbiota: A Review
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摘要: 随着城市化和工业化的快速发展，大量污染物进入到环境中，这些污染物在食物链中传递和放大，最终对人体健康产生危害。环境污染物通过摄食进入消化道，影响肠道微生物稳态，进而危害宿主健康。目前大部分研究主要集中在环境污染物对肠道微生物的丰富度和多样性的影响，而对环境污染物、肠道微生物和宿主健康互作关系的研究鲜有报道。本文综述了环境污染物包括重金属、持久性有机污染物、农药、微塑料、抗生素及其抗性基因等对肠道微生物菌群结构及其代谢活动的影响，阐明了环境污染物诱导肠道菌群失衡而致病的关键步骤，为肠道微生物毒理学评价提供新的研究思路。Abstract: With the rapid development of urbanization and industrialization, a great deal of toxic contaminants are introduced into the environments, posing an increasing risk to human health. Recently, many studies have demonstrated the profound relationships between gut microbiota (GM) and host health. However, very limited information are available on the interactions among pollutants, GM, and host health. This paper reviews the possible effects of environmental pollutants including heavy metals, persistent organic pollutants, microplastics, antibiotics and resistance genes on GM and their subsequent impacts on host health. Furthermore, we propose the key steps/models of GM disorder induced by environmental pollutants, providing a new insight into interaction between environmental pollutants and GM.
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Key words:
- environmental pollutants /
- gut microbiota /
- toxicological evaluation /
- host health
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