微塑料污染现状及其毒性效应和机制研究进展
Research Progress on Current Status of Microplastics Pollution and Its Toxic Effects and Mechanisms
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摘要: 微塑料（microplastics，MPs）作为一种新型的环境污染物近年来逐渐引起全世界的关注，除了对生态环境的影响，微塑料对生物体的毒性效应及其潜在的健康风险也日益成为环境领域的研究热点。本文基于已有研究，阐述微塑料的污染现况，总结微塑料进入机体的分布，归纳微塑料的生物毒性作用和机制，分析微塑料毒性效应的影响因素，并展望了未来的研究方向，为进一步开展微塑料的生物毒性效应、机制研究和健康风险评估提供科学线索和参考。Abstract: As a new type of environmental pollutant, microplastics have gradually attracted worldwide attention in recent years. In addition to its impact on the ecological environment, the toxic effects of microplastics on organisms and their potential health risks have increasingly become research hotspots in the environmental field. Based on the existing research, this article describes the current status of microplastics pollution, summarizes the biological toxicity effects and related mechanisms of microplastics, analyzes the factors affecting their toxic effects, and proposes the future research direction. Our review can provide scientific clues and references for further exploring the mechanisms of biological toxicity effects and health risk assessment of microplastics.
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Key words:
- microplastics /
- status of pollution /
- toxic effects /
- mechanisms of action
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周倩, 章海波, 李远, 等. 海岸环境中微塑料污染及其生态效应研究进展[J]. 科学通报, 2015, 60(33):3210-3220 Zhou Q, Zhang H B, Li Y, et al. Progress on microplastics pollution and its ecological effects in the coastal environment[J]. Chinese Science Bulletin, 2015, 60(33):3210-3220(in Chinese)
Jambeck J R, Geyer R, Wilcox C, et al. Marine pollution. Plastic waste inputs from land into the ocean[J]. Science, 2015, 347(6223):768-771 丁剑楠, 张闪闪, 邹华, 等. 淡水环境中微塑料的赋存、来源和生态毒理效应研究进展[J]. 生态环境学报, 2017, 26(9):1619-1626 Ding J N, Zhang S S, Zou H, et al. Occurrence, source and ecotoxicological effect of microplastics in freshwater environment[J]. Ecology and Environmental Sciences, 2017, 26(9):1619-1626(in Chinese)
刘强, 徐旭丹, 黄伟, 等. 海洋微塑料污染的生态效应研究进展[J]. 生态学报, 2017, 37(22):7397-7409 Liu Q, Xu X D, Huang W, et al. Research advances on the ecological effects of microplastic pollution in the marine environment[J]. Acta Ecologica Sinica, 2017, 37(22):7397-7409(in Chinese)
张霭琦. 微塑料在海洋中的分布特征及对生物的影响[J]. 资源节约与环保, 2018(12):128-129 孙承君, 蒋凤华, 李景喜, 等. 海洋中微塑料的来源、分布及生态环境影响研究进展[J]. 海洋科学进展, 2016, 34(4):449-461 Sun C J, Jiang F H, Li J X, et al. The research progress in source, distribution, ecological and environmental effects of marine microplastics[J]. Advances in Marine Science, 2016, 34(4):449-461(in Chinese)
叶李嘉, 吴南翔. 微塑料的检测及其生态环境影响研究进展[J]. 环境与职业医学, 2019, 36(12):1161-1167 , 1174 Ye L J, Wu N X. Progress on detection of microplastics and their effects on ecosystem[J]. Journal of Environmental and Occupational Medicine, 2019, 36(12):1161-1167, 1174(in Chinese)
李爱峰, 李方晓, 邱江兵, 等. 水环境中微塑料的污染现状、生物毒性及控制对策[J]. 中国海洋大学学报:自然科学版, 2019, 49(10):88-100 Li A F, Li F X, Qiu J B, et al. Pollution status, biological toxicity and control strategy of microplastics in water environments:A review[J]. Periodical of Ocean University of China, 2019, 49(10):88-100(in Chinese)
Kazour M, Jemaa S, Issa C, et al. Microplastics pollution along the Lebanese Coast (Eastern Mediterranean Basin):Occurrence in surface water, sediments and biota samples[J]. Science of the Total Environment, 2019, 696:133933 武芳竹, 曾江宁, 徐晓群, 等. 海洋微塑料污染现状及其对鱼类的生态毒理效应[J]. 海洋学报, 2019, 41(2):85-98 Wu F Z, Zeng J N, Xu X Q, et al. Status of marine microplastic pollution and its ecotoxicological effects on marine fish[J]. Acta Oceanologica Sinica, 2019, 41(2):85-98(in Chinese)
Cózar A, Echevarría F, González-Gordillo J I, et al. Plastic debris in the open ocean[J]. PNAS, 2014, 111(28):10239-10244 Lusher A L, Tirelli V, O'Connor I, et al. Microplastics in Arctic polar waters:The first reported values of particles in surface and sub-surface samples[J]. Scientific Reports, 2015, 5:14947 骆永明, 周倩, 章海波, 等. 重视土壤中微塑料污染研究防范生态与食物链风险[J]. 中国科学院院刊, 2018, 33(10):1021-1030 Luo Y M, Zhou Q, Zhang H B, et al. Pay attention to research on microplastic pollution in soil for prevention of ecological and food chain risks[J]. Bulletin of Chinese Academy of Sciences, 2018, 33(10):1021-1030(in Chinese)
Scheurer M, Bigalke M. Microplastics in Swiss floodplain soils[J]. Environmental Science & Technology, 2018, 52(6):3591-3598 Ng E L, Huerta Lwanga E, Eldridge S M, et al. An overview of microplastic and nanoplastic pollution in agroecosystems[J]. Science of the Total Environment, 2018, 627:1377-1388 Nizzetto L, Bussi G, Futter M N, et al. A theoretical assessment of microplastic transport in river catchments and their retention by soils and river sediments[J]. Environmental Science Processes & Impacts, 2016, 18(8):1050-1059 Liu M T, Lu S B, Song Y, et al. Microplastic and mesoplastic pollution in farmland soils in suburbs of Shanghai, China[J]. Environmental Pollution, 2018, 242:855-862 Zhang G S, Liu Y F. The distribution of microplastics in soil aggregate fractions in southwestern China[J]. Science of the Total Environment, 2018, 642:12-20 Fuller S, Gautam A. A procedure for measuring microplastics using pressurized fluid extraction[J]. Environmental Science & Technology, 2016, 50(11):5774-5780 Klein M, Fischer E K. Microplastic abundance in atmospheric deposition within the Metropolitan area of Hamburg, Germany[J]. Science of the Total Environment, 2019, 685:96-103 Cai L Q, Wang J D, Peng J P, et al. Correction to:Characteristic of microplastics in the atmospheric fallout from Dongguan City, China:Preliminary research and first evidence[J]. Environmental Science and Pollution Research, 2019, 26(35):36074-36075 周倩, 田崇国, 骆永明. 滨海城市大气环境中发现多种微塑料及其沉降通量差异[J]. 科学通报, 2017, 62(33):3902-3909 Zhou Q, Tian C G, Luo Y M. Various forms and deposition fluxes of microplastics identified in the coastal urban atmosphere[J]. Chinese Science Bulletin, 2017, 62(33):3902-3909(in Chinese)
Allen S, Allen D, Phoenix V R, et al. Atmospheric transport and deposition of microplastics in a remote mountain catchment[J]. Nature Geoscience, 2019, 12(5):339-344 Bergmann M, Mützel S, Primpke S, et al. White and wonderful? Microplastics prevail in snow from the Alps to the Arctic[J]. Science Advances, 2019, 5(8):eaax1157 Setälä O, Fleming-Lehtinen V, Lehtiniemi M. Ingestion and transfer of microplastics in the planktonic food web[J]. Environmental Pollution, 2014, 185:77-83 Huerta Lwanga E, Mendoza Vega J, Ku Quej V, et al. Field evidence for transfer of plastic debris along a terrestrial food chain[J]. Scientific Reports, 2017, 7(1):14071 Kashiwada S. Distribution of nanoparticles in the see-through medaka (Oryzias latipes)[J]. Environmental Health Perspectives, 2006, 114(11):1697-1702 Deng Y F, Zhang Y, Lemos B, et al. Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure[J]. Scientific Reports, 2017, 7:46687 孙尚. 微塑料对仓鼠的生物毒理效应[D]. 北京:中国科学院大学, 2019:30-35 Sun S. Biological toxicological effects of microplastics on hamsters[D]. Beijing:University of Chinese Academy of Sciences, 2019:30 -35(in Chinese)
Yong C, Valiyaveettil S, Tang B. Toxicity of microplastics and nanoplastics in mammalian systems[J]. International Journal of Environmental Research and Public Health, 2020, 17(5):1509 姜航, 丁剑楠, 黄叶菁, 等. 聚苯乙烯微塑料和罗红霉素对斜生栅藻(Scenedesmus obliquus)和大型溞(Daphnia magna)的联合效应研究[J]. 生态环境学报, 2019, 28(7):1457-1465 Jiang H, Ding J N, Huang Y J, et al. Combined effects of polystyrene microplastics and roxithromycin on the green algae (Scenedesmus obliquus) and waterflea (Daphnia magna)[J]. Ecology and Environmental Sciences, 2019, 28(7):1457-1465(in Chinese)
刘蓥蓥, 张旗, 崔文智, 等. 聚乙烯微塑料对绿豆发芽的毒性研究[J]. 环境与发展, 2019, 31(5):123-125 Liu Y Y, Zhang Q, Cui W Z, et al. Toxicity of polyethylene microplastics to seed germination of mung bean[J]. Environment and Development, 2019, 31(5):123-125(in Chinese)
廖苑辰, 娜孜依古丽·加合甫别克, 李梅, 等. 微塑料对小麦生长及生理生化特性的影响[J]. 环境科学, 2019, 40(10):4661-4667 Liao Y C, Nazygul·Jahitbek, Li M, et al. Effects of microplastics on the growth, physiology, and biochemical characteristics of wheat (Triticum aestivum)[J]. Environmental Science, 2019, 40(10):4661-4667(in Chinese)
孙晓东. 不同电荷纳米塑料在拟南芥体内的毒性、吸收和积累[D]. 济南:山东大学, 2019:28-33 Sun X D. Phytotoxicity, uptake and accumulation of differentially charged nanoplastics in Arabidopsis thaliana[D]. Ji'nan:Shandong University, 2019:28 -33(in Chinese)
Pannetier P, Morin B, Le Bihanic F, et al. Environmental samples of microplastics induce significant toxic effects in fish larvae[J]. Environment International, 2020, 134:105047 Yang H, Xiong H R, Mi K H, et al. Toxicity comparison of nano-sized and micron-sized microplastics to Goldfish Carassius auratus larvae[J]. Journal of Hazardous Materials, 2020, 388:122058 Cong Y, Jin F, Tian M, et al. Ingestion, egestion and post-exposure effects of polystyrene microspheres on marine medaka (Oryzias melastigma)[J]. Chemosphere, 2019, 228:93-100 Ding J N, Zhang S S, Razanajatovo R M, et al. Accumulation, tissue distribution, and biochemical effects of polystyrene microplastics in the freshwater fish red tilapia (Oreochromis niloticus)[J]. Environmental Pollution, 2018, 238:1-9 Barboza L G A, Vieira L R, Branco V, et al. Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758)[J]. Aquatic Toxicology, 2018, 195:49-57 Chen Q Q, Gundlach M, Yang S Y, et al. Quantitative investigation of the mechanisms of microplastics and nanoplastics toward zebrafish larvae locomotor activity[J]. Science of the Total Environment, 2017, 584-585:1022-1031 Poma A N, Vecchiotti G, Colafarina S, et al. In vitro genotoxicity of polystyrene nanoparticles on the human fibroblast Hs27 cell line[J]. Nanomaterials, 2019, 9(9):1299 Li B Q, Ding Y F, Cheng X, et al. Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice[J]. Chemosphere, 2020, 244:125492 Jin Y X, Lu L, Tu W Q, et al. Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice[J]. Science of the Total Environment, 2019, 649:308-317 万志琴. 聚苯乙烯微塑料对斑马鱼菌群和代谢的影响[D]. 杭州:浙江工业大学, 2019:18-50 Wan Z Q. Effects of polystyrene microplastics on the microbiota and metabolism in zebrafish[D]. Hangzhou:Zhejiang University of Technology, 2019:18 -50(in Chinese)
雷丽丽. 微塑料颗粒对秀丽线虫和斑马鱼的毒性效应及其机制[D]. 上海:华东师范大学, 2019:17-57 Lei L L. Toxic effects and mechanisms of microplastic particles on Caenorhabditis elegans and Danio rerio[D]. Shanghai:East China Normal University, 2019:17 -57(in Chinese)
Lu L, Wan Z Q, Luo T, et al. Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice[J]. Science of the Total Environment, 2018, 631-632:449-458 Luo T, Wang C Y, Pan Z H, et al. Maternal polystyrene microplastic exposure during gestation and lactation altered metabolic homeostasis in the dams and their F1 and F2 offspring[J]. Environmental Science & Technology, 2019, 53(18):10978-10992 Domenech J, Hernández A, Demir E, et al. Interactions of graphene oxide and graphene nanoplatelets with the in vitro Caco-2/HT29 model of intestinal barrier[J]. Scientific Reports, 2020, 10:2793 洪文秀. 典型微塑料对优势底栖动物的毒性效应研究[D]. 芜湖:安徽师范大学, 2019:44-53 Hong W X. Toxic effects of typical microplastics on dominant benthic animals[D]. Wuhu:Anhui Normal University, 2019:44 -53(in Chinese)
Yang Y F, Chen C Y, Lu T H, et al. Toxicity-based toxicokinetic/toxicodynamic assessment for bioaccumulation of polystyrene microplastics in mice[J]. Journal of Hazardous Materials, 2019, 366:703-713 Treyer A, Pujato M, Pechuan X, et al. Iterative sorting of apical and basolateral cargo in Madin-Darby canine kidney cells[J]. Molecular Biology of the Cell, 2016, 27(14):2259-2271 Horstmann H, Ng C P, Tang B L, et al. Ultrastructural characterization of endoplasmic reticulum-Golgi transport containers (EGTC)[J]. Journal of Cell Science, 2002, 115(22):4263-4273 Greven A C, Merk T, Karag z F, et al. Polycarbonate and polystyrene nanoplastic particles act as stressors to the innate immune system of fathead minnow (Pimephales promelas)[J]. Environmental Toxicology and Chemistry, 2016, 35(12):3093-3100 曹露, 李永, 梁瑞峰, 等. 微塑料颗粒对虹鳟免疫基因表达的影响[J]. 环境科学学报, 2018, 38(8):3347-3352 Cao L, Li Y, Liang R F, et al. Effects of microplastic particles on immune gene expression of rainbow trout[J]. Acta Scientiae Circumstantiae, 2018, 38(8):3347-3352(in Chinese)
Hwang J, Choi D, Han S, et al. An assessment of the toxicity of polypropylene microplastics in human derived cells[J]. Science of the Total Environment, 2019, 684:657-669 Xu M K, Halimu G, Zhang Q R, et al. Internalization and toxicity:A preliminary study of effects of nanoplastic particles on human lung epithelial cell[J]. Science of the Total Environment, 2019, 694:133794 da Costa Araújo A P, Malafaia G. Microplastic ingestion induces behavioral disorders in mice:A preliminary study on the trophic transfer effects via tadpoles and fish[J]. Journal of Hazardous Materials, 2021, 401:123263 L nnstedt O M, Ekl v P. Environmentally relevant concentrations of microplastic particles influence larval fish ecology[J]. Science, 2016, 352(6290):1213-1216 Lee K W, Shim W J, Kwon O Y, et al. Size-dependent effects of micro polystyrene particles in the marine copepod Tigriopus japonicas[J]. Environmental Science & Technology, 2013, 47(19):11278-11283 Choi J S, Hong S H, Park J W. Evaluation of microplastic toxicity in accordance with different sizes and exposure times in the marine copepod Tigriopus japonicas[J]. Marine Environmental Research, 2020, 153:104838 Sussarellu R, Suquet M, Thomas Y, et al. Oyster reproduction is affected by exposure to polystyrene microplastics[J]. PNAS, 2016, 113(9):2430-2435 Jin H B, Ma T, Sha X X, et al. Polystyrene microplastics induced male reproductive toxicity in mice[J]. Journal of Hazardous Materials, 2021, 401:123430 Hou B L, Wang F Y, Liu T, et al. Reproductive toxicity of polystyrene microplastics:In vivo experimental study on testicular toxicity in mice[J]. Journal of Hazardous Materials, 2021, 405:124028 Xie X M, Deng T, Duan J F, et al. Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway[J]. Ecotoxicology and Environmental Safety, 2020, 190:110133 Bedard K, Krause K H. The NOX family of ROS-generating NADPH oxidases:Physiology and pathophysiology[J]. Physiological Reviews, 2007, 87(1):245-313 万升理, 郑新宇, 潘星任, 等. 微塑料的环境行为与生物毒性研究[J]. 广东化工, 2019, 46(3):101-102 , 110 Wan S L, Zheng X Y, Pan X R, et al. Research on the environmental behavior and biological toxicity of microplastics[J]. Guangdong Chemical Industry, 2019, 46(3):101-102, 110(in Chinese)
徐擎擎, 张哿, 邹亚丹, 等. 微塑料与有机污染物的相互作用研究进展[J]. 生态毒理学报, 2018, 13(1):40-49 Xu Q Q, Zhang G, Zou Y D, et al. Interactions between microplastics and organic pollutants:Current status and knowledge gaps[J]. Asian Journal of Ecotoxicology, 2018, 13(1):40-49(in Chinese)
杨婧婧, 徐笠, 陆安祥, 等. 环境中微(纳米)塑料的来源及毒理学研究进展[J]. 环境化学, 2018, 37(3):383-396 Yang J J, Xu L, Lu A X, et al. Research progress on the sources and toxicology of micro (nano) plastics in environment[J]. Environmental Chemistry, 2018, 37(3):383-396(in Chinese)
Nolte T M, Hartmann N B, Kleijn J M, et al. The toxicity of plastic nanoparticles to green algae as influenced by surface modification, medium hardness and cellular adsorption[J]. Aquatic Toxicology, 2017, 183:11-20 Zhang C, Chen X H, Wang J T, et al. Toxic effects of microplastic on marine microalgae Skeletonema costatum:Interactions between microplastic and algae[J]. Environmental Pollution, 2017, 220:1282-1288 李连祯, 周倩, 尹娜, 等. 食用蔬菜能吸收和积累微塑料[J]. 科学通报, 2019, 64(9):928-934 Li L Z, Zhou Q, Yin N, et al. Uptake and accumulation of microplastics in an edible plant[J]. Chinese Science Bulletin, 2019, 64(9):928-934(in Chinese)
Lu L, Wan Z Q, Luo T, et al. Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice[J]. Science of the Total Environment, 2018, 631-632:449-458 王一飞, 李淼, 于海瀛, 等. 微塑料对环境中有机污染物吸附解吸的研究进展[J]. 生态毒理学报, 2019, 14(4):23-30 Wang Y F, Li M, Yu H Y, et al. Research progress on the adsorption and desorption between microplastics and environmental organic pollutants[J]. Asian Journal of Ecotoxicology, 2019, 14(4):23-30(in Chinese)
周瑛, 徐博凡, 王萍亚, 等. 微塑料对水体中痕量砷、铅的吸附[J]. 浙江工业大学学报, 2019, 47(6):648-653 Zhou Y, Xu B F, Wang P Y, et al. Study on the adsorption of trace arsenic and plumbum ion by microplastics[J]. Journal of Zhejiang University of Technology, 2019, 47(6):648-653(in Chinese)
孙聪惠. 渤海湾滨海潮间带微塑料和重金属污染及生态风险[D]. 天津:天津师范大学, 2018:20-22 Sun C H. Microplastics and heavy metal pollution in the intertidal zone of Bohai Bay and its ecological risks[D]. Tianjin:Tianjin Normal University, 2018:20 -22(in Chinese)
Gandara e Silva P P, Nobre C R, Resaffe P, et al. Leachate from microplastics impairs larval development in brown mussels[J]. Water Research, 2016, 106:364-370 Deng Y F, Zhang Y, Qiao R X, et al. Evidence that microplastics aggravate the toxicity of organophosphorus flame retardants in mice (Mus musculus)[J]. Journal of Hazardous Materials, 2018, 357:348-354 -
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