稀土掺杂的上转换纳米材料的生物毒性与其作用机制研究进展
Research Progress on Biological Toxicity and Its Mechanism of Rare-earth-elements-doped Upconversion Nanoparticles
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摘要: 稀土掺杂的上转换纳米材料（rare-earth-elements-doped upconversion nanoparticles，REEs-UCNPs）作为新兴一代的荧光纳米探针，具有独特而优异的反斯托克斯发光特点，与传统荧光材料相比，具有发光强度高、荧光寿命长、激发能量低、组织穿透能力强和生物相容性好等优点。近年来，REEs-UCNPs在生物医学、活体荧光成像、太阳能电池和卫生检测等领域应用日益广泛，其环境和人群暴露日益突出。随着纳米毒理学的深入研究，REEs-UCNPs的生物学毒性效应以及对环境和人类健康的影响逐渐被研究者关注，然而目前有关REEs-UCNPs的生物学毒性的报道较少。本文综述了近年来有关REEs-UCNPs在生物体内的吸收-分布-代谢-排泄、生物毒性、毒作用机制与影响因素等方面的研究进展，以期为REEs-UCNPs的进一步开发、应用和深入研究提供思路和参考依据。
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关键词:
- 稀土掺杂的上转换纳米材料 /
- 生物毒性 /
- 研究进展
Abstract: As a new generation of fluorescent nanoprobes, rare-earth-elements-doped upconversion nanomaterials (REEs-UCNPs) have unique conversion properties of anti-Stokes luminescence, and have remarkable advantages such as high luminous intensity, long fluorescence lifetime, low excitation energy, large penetration depth of excited light in biological tissue and little tissue damage, etc. In recent years, REEs-UCNPs have been widely used in biomedicine, in vivo fluorescence imaging, solar cells, health detection and other fields, and their environmental and human exposure have become increasingly prominent. With the in-depth study of nano toxicology, the biological toxic effects of REEs-UCNPs and their impact on environment and human health have been gradually concerned by researchers. However, there are few reports on the biological toxicity of REEs-UCNPs. In order to provide ideas and reference basis for the further development, application and in-depth research of REEs-UCNPs, this paper reviews the research progress on the biological absorption-distribution-metabolism-excretion, biological toxicity, toxic mechanism and their influencing factors of REEs-UCNPs in recent years. -
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