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响应面法建立不同经口介质中邻苯二甲酸酯生物有效性预测模型及相关因素

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杨彦, 倪玮玮, 李定龙, 车飞, 李晓芳, 吕浩. 响应面法建立不同经口介质中邻苯二甲酸酯生物有效性预测模型及相关因素[J]. 环境化学, 2014, 33(11): 1893-1905. doi: 10.7524/j.issn.0254-6108.2014.11.014
引用本文: 杨彦, 倪玮玮, 李定龙, 车飞, 李晓芳, 吕浩. 响应面法建立不同经口介质中邻苯二甲酸酯生物有效性预测模型及相关因素[J]. 环境化学, 2014, 33(11): 1893-1905. doi: 10.7524/j.issn.0254-6108.2014.11.014
shu
YANG Yan, NI Weiwei, LI Dinglong, CHE Fei, LI Xiaofang, LYU Hao. Response surface methodology to establish prediction models and related factors for bioaccessibility of PAEs via oral different media[J]. Environmental Chemistry, 2014, 33(11): 1893-1905. doi: 10.7524/j.issn.0254-6108.2014.11.014
Citation: YANG Yan, NI Weiwei, LI Dinglong, CHE Fei, LI Xiaofang, LYU Hao. Response surface methodology to establish prediction models and related factors for bioaccessibility of PAEs via oral different media[J]. Environmental Chemistry, 2014, 33(11): 1893-1905. doi: 10.7524/j.issn.0254-6108.2014.11.014
shu

响应面法建立不同经口介质中邻苯二甲酸酯生物有效性预测模型及相关因素

  • 1.

    常州大学环境与安全工程学院, 常州, 213164;

  • 2.

    中国环境科学研究院, 北京, 100012

  • 基金项目:

    国家自然科学基金(21377045,21177119)

    江苏省环保科研课题(2012018)资助.

Response surface methodology to establish prediction models and related factors for bioaccessibility of PAEs via oral different media

  • 1.

    School of Environment & Safety Engineering, Changzhou University, Changzhou, 213164, China;

  • 2.

    China Research Academy of Environmental Sciences, Beijing, 100012, China

  • Fund Project:

  • 摘要: 运用响应面法对不同消化基质下邻苯二甲酸酯(PAEs)生物有效性的相关因素进行筛选建立预测模型,并对主要因素设定值进行分析.研究表明,3种模型中因变量与自变量之间的相关性较好(土壤:R2=0.959;农作物及植物:R2=0.973;脂肪:R2=0.862),模型拟合度较高.通过多次试验模拟,初步认为在土壤消化基质中,设置人体摄入PAEs经口摄入浓度为10 μg·g-1,基质质量为0.4 g,pH值约为7时,生物吸收量最高.在植物源基质下,污染物浓度在10-11 μg·g-1,消化时间在6-7 h,基质质量为0.4 g为生物吸收量最高.脂肪源中,基质质量在0.4 g,污染物浓度在10 μg·g-1,脂肪量在10%-11%时,PAEs生物吸收量最高.研究通过重复试验,充分体现了该模型的准确性,及设定条件的可靠性.但本研究仅考虑摄入介质相对单一,污染物化合形态等未在考虑范围内,在后期研究中将补充试验.
    Abstract: Using response surface methodology for the bioaccessibility of PAEs, the relevant factors were chosen and prediction models were established under different digestion media. Studies have shown that the three models had a good correlation between the dependent and independent variables (soil: R2=0.959; crops and plants: R2=0.973; fat: R2=0.862), and model fit was high. Through several simulated experiments, it was formed that when phthalate acid esters concentration from oral intake was 10 μg·g-1, quality was 0.4 g, and pH was 7 in the soil media, biological absorption was highest. When phthalate acid esters concentration was between 10 μg·g-1 and 11 μg·g-1, digestion time was from 6 h to 7 h, and quality was 0.4 g in the crops and plants media, biological absorption was highest. When quality was 0.4 g, phthalate acid esters concentration was 10 μg·g-1, fat was between 10% and 11%, biological absorption was highest. In the repeating tests, the model was accurate, and the condition set was reliable.
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  • [1] 孙大贵,陶长元,刘作华,等.活性炭-Fenton组合法去除水中PAEs的研究[J].环境科学,2007,28(12):2734-2739
    [2] Ema M,Miyawaki E,Kawashima K. Effects of dibutyl phthalate on reproductive function in pregnant and pseudopregnantrats[J]. Reproductive Toxicology,2000,14(1):13-19
    [3] Salazar V,Castillo C,Ariznavarreta C,et al. Effect of oral intake of dibutyl phthalate on reproductive parameters of Long Evans rats and pre-pubertal development of their offspring[J]. Toxicology,2004,205(1):131-137
    [4] 刘庆,杨红军,史衍玺,等.环境中邻苯二甲酸酯类(PAEs)污染物研究进展[J].中国生态农业学报,2012,20(8):968-975
    [5] Kang Y,Man Y B,Cheung K C,et al. Risk assessment of human exposure to bioaccessible phthalate esters via indoor dust around the pearl river delta[J]. Environmental science & technology,2012,46(15):8422-8430
    [6] Versantvoort C H M,Oomen A G,Van de Kamp E,et al. Applicability of an in vitro digestion model in assessing the bioaccessibility of mycotoxins from food[J]. Food and Chemical Toxicology,2005,43(1):31-40
    [7] Wang Y,Song L,Hong X,et al. Low concentrations mono-butyl phthalate stimulates steroidogenesis by facilitating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1)[J]. Chemico-biological interactions,2006,164(1):15-24
    [8] 杨彦,王宗庆,李定龙,等.中国太湖流域(江苏南部)人群复合污染经口途径风险暴露评估[J].环境科学学报,2013,33(5):1410-1422
    [9] 唐翔宇,朱永官,陈世宝.In Vitro法评估铅污染土壤对人体的生物有效性[J].环境化学,2003,22(5):503-506
    [10] Rodriguez R R,Basta N T,Casteel S W,et al. An in vitro gastrointestinal method to estimate bioavailable arsenic in contaminated soils and solid media[J]. Environmental Science & Technology,1999,33(4):642-649
    [11] Dean J R,Ma R. Approaches to assess the oral bioaccessibility of persistent organic pollutants: a critical review[J]. Chemosphere,2007,68(8):1399-1407
    [12] 张东平,余应新,张帆,等.环境污染物对人体生物有效性测定的胃肠模拟研究现状[J].科学通报,2008,53(21):2537-2545
    [13] Oomen A G,Hack A,Minekus M,et al. Comparison of five in vitro digestion models to study the bioaccessibility of soil contaminants[J]. Environmental science & technology,2002,36(15):3326-3334
    [14] Laird B D,Van de Wiele T R,Corriveau M C,et al. Gastrointestinal microbes increase arsenic bioaccessibility of ingested mine tailings using the simulator of the human intestinal microbial ecosystem[J]. Environmental science & technology,2007,41(15):5542-5547
    [15] Oomen A G,Rompelberg C J M,Van de Kamp E,et al. Effect of bile type on the bioaccessibility of soil contaminants in an in vitro digestion model[J]. Archives of Environmental Contamination and Toxicology,2004,46(2):183-188
    [16] Crolla A,Kennedy K J. Optimization of citric acid production from Candida lipolytica Y-1095 using n-paraffin[J]. Journal of Biotechnology,2001,89(1):27-40
    [17] Ruby M V,Davis A,Link T E,et al. Development of an in vitro screening test to evaluate the in vivo bioaccessibility of ingested mine-waste lead[J]. Environmental science & technology,1993,27(13):2870-2877
    [18] Xing G H,Yang Y,Yan Chan J K,et al. Bioaccessibility of polychlorinated biphenyls in different foods using an in vitro digestion method[J]. Environmental pollution,2008,156(3):1218-1226
    [19] 钱毅玲,赵谋明,赵强忠.亲水胶体在乳化肠体系的Plackett-Burman法筛选中的应用[J].食品科学,2009,(22):192-196
    [20] 李琛,余应新,张东平,等.上海室内外灰尘中多氯联苯及其人体暴露评估[J].中国环境科学,2010,30(4):433-441
    [21] Yu Y,Han S,Zhang D,et al. Factors affecting the bioaccessibility of polybrominated diphenyl ethers in an in vitro digestion model[J]. Journal of Agricultural and Food Chemistry,2008,57(1):133-139
    [22] 徐瑾,陈广春,何欢,等.应用体外胃肠模拟法研究土壤中多氯联苯的生物有效性[J].环境化学,2011,30(5):908-912
    [23] Appel C,Ma L. Concentration, pH, and surface charge effects on cadmium and lead sorption in three tropical soils[J]. Journal of Environmental Quality,2002,31(2):581-589
    [24] 崔岩山,陈晓晨,付瑾.污染土壤中铅,砷的生物可给性研究进展[J].生态环境学报,2010,19(2):480-486
    [25] Kulkarni S D,Acharya R,Rajurkar N S,et al. Evaluation of bioaccessibility of some essential elements from wheatgrass (Triticumaestivum L.) by in vitro digestion method[J]. Food chemistry,2007,103(2):681-688
    [26] 陆敏,余应新,张东平,等.胡萝卜中滴滴涕对人体生物有效性影响因素的体外研究[J].环境化学,2009,28(2):220-224
    [27] Wittsiepe J,Erlenkämper B,Welge P,et al. Bioavailability of PCDD/F from contaminated soil in young Goettingen minipigs[J]. Chemosphere,2007,67(9):S355-S364
    [28] 韩姝媛,余应新,李俊岭,等.上海地区肉类和鱼类食品中多氯联苯含量特征及其对人体的生物有效性[J].环境科学学报,2010,30(6):1322-1330
    [29] Dinkelaker B,Romheld V, Marshner H. Citric acid excretion and precipitation of calcium citrate in the rhizosphere of white lupin[J]. Plant,cell and Environment,1989,12:285-292
    [30] Yang J K,Barnett M O,Jardine P M,et al. Adsorption,sequestration,and bioaccessibility of As (V) in soils[J]. Environmental science & technology,2002,36(21):4562-4569
    [31] He M,Ke C H,Wang W X. Effects of cooking and subcellular distribution on the bioaccessibility of trace elements in two marine fish species[J]. Journal of agricultural and food chemistry,2010,58(6):3517-3523
    [32] 杨冀艳,胡磊,许杨.Plackett-Burman设计和响应面法优化荷叶总黄酮的提取工艺[J].食品科学,2009,30(6):29-33
    [33] 国蓉,李剑君,国亮,等.采用响应曲面法优化甘草饮片中甘草酸的超声提取工艺[J].西北农林科技大学学报:自然科学版,2006,34(9):187-192
    [34] Hack A,Selenka F. Mobilization of PAH and PCB from contaminated soil using a digestive tract model[J]. Toxicology letters,1996,88(1):199-210
    [35] Khan S,Cao Q,Lin A J,et al. Concentrations and bioaccessibility of polycyclic aromatic hydrocarbons in wastewater-irrigated soil using in vitro gastrointestinal test[J]. Environmental Science and Pollution Research-International,2008,15(4):344-353
    [36] 陆敏,韩姝媛,余应新,等.蔬菜中多溴联苯醚的定量测定及其对人体的生物有效性[J].分析测试学报,2009,28(1):1-6
    [37] Yu Y X,Li J L,Zhang X Y,et al. Assessment of the bioaccessibility of polybrominated diphenyl ethers in foods and the correlations of the bioaccessibility with nutrient contents[J]. Journal of agricultural and food chemistry,2009,58(1):301-308
    [38] 李俊岭,张东平,余应新,等.动物性食品中PCBs的生物有效性及人体日暴露评估[J].中国环境科学,2011,31(6):1019-1028
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  • 收稿日期:  2014-01-16
  • 刊出日期:  2014-11-15
杨彦, 倪玮玮, 李定龙, 车飞, 李晓芳, 吕浩. 响应面法建立不同经口介质中邻苯二甲酸酯生物有效性预测模型及相关因素[J]. 环境化学, 2014, 33(11): 1893-1905. doi: 10.7524/j.issn.0254-6108.2014.11.014
引用本文: 杨彦, 倪玮玮, 李定龙, 车飞, 李晓芳, 吕浩. 响应面法建立不同经口介质中邻苯二甲酸酯生物有效性预测模型及相关因素[J]. 环境化学, 2014, 33(11): 1893-1905. doi: 10.7524/j.issn.0254-6108.2014.11.014
shu
YANG Yan, NI Weiwei, LI Dinglong, CHE Fei, LI Xiaofang, LYU Hao. Response surface methodology to establish prediction models and related factors for bioaccessibility of PAEs via oral different media[J]. Environmental Chemistry, 2014, 33(11): 1893-1905. doi: 10.7524/j.issn.0254-6108.2014.11.014
Citation: YANG Yan, NI Weiwei, LI Dinglong, CHE Fei, LI Xiaofang, LYU Hao. Response surface methodology to establish prediction models and related factors for bioaccessibility of PAEs via oral different media[J]. Environmental Chemistry, 2014, 33(11): 1893-1905. doi: 10.7524/j.issn.0254-6108.2014.11.014
shu

响应面法建立不同经口介质中邻苯二甲酸酯生物有效性预测模型及相关因素

  • 1.  常州大学环境与安全工程学院, 常州, 213164;
  • 2.  中国环境科学研究院, 北京, 100012
  • 收稿日期:  2014-01-16
基金项目:

国家自然科学基金(21377045,21177119)

江苏省环保科研课题(2012018)资助.

摘要: 运用响应面法对不同消化基质下邻苯二甲酸酯(PAEs)生物有效性的相关因素进行筛选建立预测模型,并对主要因素设定值进行分析.研究表明,3种模型中因变量与自变量之间的相关性较好(土壤:R2=0.959;农作物及植物:R2=0.973;脂肪:R2=0.862),模型拟合度较高.通过多次试验模拟,初步认为在土壤消化基质中,设置人体摄入PAEs经口摄入浓度为10 μg·g-1,基质质量为0.4 g,pH值约为7时,生物吸收量最高.在植物源基质下,污染物浓度在10-11 μg·g-1,消化时间在6-7 h,基质质量为0.4 g为生物吸收量最高.脂肪源中,基质质量在0.4 g,污染物浓度在10 μg·g-1,脂肪量在10%-11%时,PAEs生物吸收量最高.研究通过重复试验,充分体现了该模型的准确性,及设定条件的可靠性.但本研究仅考虑摄入介质相对单一,污染物化合形态等未在考虑范围内,在后期研究中将补充试验.

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