Keywords: 
• fluoride /
• Cipangopaludina cahayensis /
• hepatopancreas /
• antioxidant related enzymes

Abstract: The effects of fluoride on the activities of antioxidant enzymes (SOD, GSH and POD) and MDA levels were measured in hepatopancreas of Cipangopaludina cahayensis exposed to different concentrations of fluoride (0, 40, 80, 160 mg·L^-1) for 30 days. The results indicated that compared with the control group, SOD activities were induced in the low concentration group but were inhibited in the high concentration group after 20 days exposure. After exposure for 30 days, SOD activities were decreased in hepatopancreas of Cipangopaludina cahayensis exposed to low and medium concentration fluoride, while were gradually increased in high concentration group. MDA contents were induced in the hepatopancreas of Cipangopaludina cahayensis exposed to low and medium concentrations while were inhibited in the high concentration group for 20 days. After exposure for 30 days, the MDA contents were significantly inhibited compared with that in the control group. GSH activities were higher in the hepatopancreas of Cipangopaludina cahayensis during the whole exposure period. POD activities were decreased compared with those in the control group after 10 days exposure, and then were elevated after 20 days exposure, while were inhibited after 30 days exposure. All the results would provide the basic data for water pollution control and ecological risk assessment.