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江媛媛1,2,党菲2,李敏2,周东美2,吴笛3,施维林1,*,朱雪峰4,#. 口服纳米银对大鼠的生物有效性及其体内分布的研究[J]. 生态毒理学报, 2017, 12(6): 215-222
口服纳米银对大鼠的生物有效性及其体内分布的研究
Bioavailability and Distribution of Nanosilver after Oral Administration in Rats
投稿时间:2016-09-02  修订日期:2016-10-24
DOI:10.7524/AJE.1673-5897.20160902002
中文关键词:  AgNP  SD大鼠  累积  生物有效性
英文关键词:AgNP  Sprague-Dawley rats  accumulation  bioavailability
基金项目:国家自然科学基金项目(No. 41430752, 31570515);江苏省自然科学基金项目(BK20131041);苏州市科技支撑计划项目(SS201421,SS201523);江苏高校水处理技术与材料协同创新项目;苏州市环保科技项目(2015-3)
作者单位
江媛媛1,2,党菲2,李敏2,周东美2,吴笛3,施维林1,*,朱雪峰4,# 1. 苏州科技大学环境科学与工程学院 苏州 215009 2. 中国科学院南京土壤研究所土壤环境与污染修复重点实验室南京 210008 3. 南京医科大学公共卫生学院毒理系南京 210029 4. 南京医科大学公共卫生学院江苏省医药兽药安全性评价与研究中心南京 210029 
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中文摘要:
      由于独特的抗菌特性,纳米银(AgNP)在诸多领域得到广泛应用,但是其生物有效性、动物组织分布及排出尚不清楚。将聚乙烯吡咯烷酮包被的AgNP溶液按照10 mg kg-1给雌性SD大鼠灌胃,采用ICP-MS检测SD大鼠组织、粪便及尿液中总银浓度。结果表明,AgNP通过小肠吸收后,可以通过血液循环快速分布在肝、肾、脾、肺、脑等靶器官。灌胃后1 h,大鼠各组织中总银浓度达到最大值(肝、肾、脾、肺、脑中银浓度分别为(0.29 ± 0.13) mg kg-1、(0.23 ± 0.04) mg kg-1、(0.17 ± 0.05) mg kg-1、(0.11 ± 0.01) mg kg-1、(0.06 ±0.02) mg kg-1),之后银浓度随时间而降低,直至和对照组无显著性差异。在灌胃途径下,AgNP对SD大鼠的有效性为8.5%,且73%的AgNP是通过粪便的途径排出体外。
  
AuthorAffiliation
Jiang Yuanyuan1,2, Dang Fei2, Li Min2, Zhou Dongmei2, Wu Di3, Shi Weilin1,*, Zhu Xuefeng4,#1. School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China 2. Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China 3. Department of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China 4. Safety Evaluation and Research Center of Medicine and Veterinary Medicine of Jiangsu Province, School of Public Health, Nanjing Medical University, Nanjing 210029, China
英文摘要:
      Due to the unique antimicrobial properties, nanosilver (AgNP) are widely applied in many fields. However, its bioavailability, tissue distribution and excretion in rats are less known. Female Sprague-Dawley rats were treated by a single intragastic administration of 10 mg kg-1 polyvinylpyrrolidone-AgNPs, and rat tissues, feces and urine were collected periodically to analyze total Ag concentrations by ICP-MS. The results showed that after uptake by gastrointestine, AgNP was transported via the blood circulation and distributed to tissues such as liver, kidney, spleen, lung, and brain. At 1 h after AgNP exposure, total silver accumulation in those tissues peaked (i.e. 0.29 ± 0.13 mg kg-1, 0.23 ± 0.04 mg kg-1, 0.17 ± 0.05 mg kg-1, 0.11 ± 0.01 mg kg-1 and 0.06 ± 0.02 mg kg-1 for liver, kidney, spleen, lung and brain, respectively), and declined to background levels over time. Our calculation showed that the bioavailability of AgNP to Sprague-Dawley rats via intragastric administration was 8.5%. Especially, 73% of the dosed AgNP was excreted via feces.
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