不能将值 NULL 插入列 'id',表 'aje_website.dbo.t_web_site_access';列不允许有空值。INSERT 失败。 语句已终止。 欢迎访问《生态毒理学报》编辑部网站!

首页 | 期刊简介 | 编委会 | 投稿要求 | 化学品管理信息动态 | 学术会议 | 专辑 | 毒理学测试技术设备 | 订购本刊 | 联系我们 | English version

邓林,龚玲,杨家书,赖诗韵,陈阳,林居纯*. 复方阿苯达唑/伊维菌素及其单药的体内外致突变性研究[J]. 生态毒理学报, 2017, 12(5): 313-320
复方阿苯达唑/伊维菌素及其单药的体内外致突变性研究
Mutagenic Effects of the Combination and Its Components of Albendazole and Ivermectin in vivo and in vitro
投稿时间:2016-09-23  修订日期:2017-02-04
DOI:10.7524/AJE.1673-5897.20160923002
中文关键词:  阿苯达唑  伊维菌素  复方  单药  小鼠  致突变
英文关键词:albendazole  ivermectin  compound preparation  mice  mutagenic effects
基金项目:2016年质量工程-大学生创新创业训练计划
作者单位
邓林,龚玲,杨家书,赖诗韵,陈阳,林居纯* 四川农业大学动物医学院成都 611130 
摘要点击次数: 277
全文下载次数: 275
中文摘要:
      农业生产上常用的阿苯达唑和伊维菌素均有一定的致突变性。为了解伊维菌素和阿苯达唑按1:24形成固定剂量复方的致突变性,以及复方和单药致突变性的差异,采用Ames试验、小鼠骨髓微核试验和小鼠精子畸变试验进行复方阿苯达唑/伊维菌素及其单药的致突变性研究。结果表明,复方阿苯达唑/伊维菌素能提高小鼠骨髓嗜多染红细胞的微核率和精子畸形率,但在单复方的比较中发现,单药的微核率和精子畸形率均高于复方,表明复方毒性有所降低。同时,无论是复方还是单药均不能提高组氨酸缺陷型沙门氏菌的突变率。以上表明,虽然复方阿苯达唑/伊维菌素致突变毒性低于单药,但仍然是一种能引起小鼠骨髓微核率和精子畸形率升高的致突变阳性药物,因此需警惕该药物的食品残留问题及对生态环境的危害。
  
AuthorAffiliation
Deng Lin, Gong Ling, Yang Jiashu, Lai Shiyun, Chen Yang, LinJuchun*College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
英文摘要:
      Albendazole and ivermectin, common antiparasitic drugs widely used in livestock production, showed mutagenic effects in some extent. The mutagenic effects of the combination (1:24=ivermectin: albendazole) and its components of ivermectin and albendazole were investigated by utilizing Ames test, mouse bone marrow micronucleus test and mouse sperm aberration test. We found that the micronucleus frequency of bone marrow and the frequency of sperm abnormality were increased in mice treated with the combination. In comparison with the combination, the mice treated with ivermectin or albendazole showed higher micronucleus frequency and sperm abnormality rate. However, no differences were observed in the salmonella mutagenicity test in the combination and its components. The results indicated that the combination of ivermectin and albendazole (1:24) caused a certain degree of mutagenic effects, but the mutation frequency were lower than its components separately. Therefore, special attention should be paid to the drug residues in food and the ecological risk.
查看全文  查看/发表评论  下载PDF阅读器
关闭

您是第4146080位访问者   京ICP备 09058833 号

主办单位:中国科学院生态环境研究中心     单位地址:北京市海淀区双清路18号

 服务热线:010-62941072       传真:010-62923563       邮编:100085    Email: stdlxb@rcees.ac.cn

    本系统由北京勤云科技发展有限公司设计

0463美女美女3764美女美女ktv