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陈香平1,黄长江2,陈元红2,刘滨3,刘翠平3,朱亚先4,张勇1,*. 铅和得克隆联合暴露对斑马鱼胚胎的神经毒性作用[J]. 生态毒理学报, 2017, 12(3): 309-316
铅和得克隆联合暴露对斑马鱼胚胎的神经毒性作用
Neurotoxic Effects of Co-exposure to Lead and Dechlorane Plus on Zebrafish (Danio rerio) Embryos
投稿时间:2016-11-09  修订日期:2016-12-17
DOI:10.7524/AJE.1673-5897.20161109001
中文关键词:    得克隆  斑马鱼  胚胎  神经毒性  联合暴露
英文关键词:lead  Dechlorane Plus  zebrafish  embryo  neurotoxicity  co-exposure
基金项目:国家自然科学基金项目(21577110);高等学校博士学科点专项科研基金(20130121130005)
作者单位
陈香平1,黄长江2,陈元红2,刘滨3,刘翠平3,朱亚先4,张勇1,* 1. 近海海洋环境科学国家重点实验室(厦门大学)厦门大学环境与生态学院厦门 361102 2. 温州医科大学公共卫生与管理学院温州 325035 3. 温州出入境检验检疫局温州 325027 4. 厦门大学化学化工学院化学系厦门 361102 
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中文摘要:
      以斑马鱼(Danio rerio)为研究对象,探讨铅(Pb)、得克隆(DP)及二者联合急性暴露对斑马鱼胚胎的神经毒性作用。结果表明,Pb(5、20 μg L-1)和DP(15、60 μg L-1)单独暴露均会引起斑马鱼自主运动频率增加,触摸反应能力和自由游泳活力下降,并且抑制初级运动神经元的生长,加剧尾部细胞凋亡。但与20 μg L-1 Pb单独暴露相比,高剂量联合暴露(20 μg L-1 Pb + 60 μg L-1 DP)使斑马鱼的自主运动频率显著降低(P < 0.05),触摸反应能力和自由游泳活力显著增强(P < 0.05),初级运动神经元轴突长度显著增加(P < 0.05),尾部细胞凋亡减少。与5 μg L-1 Pb单独暴露相比,低剂量联合暴露(5 μg L-1 Pb + 15 μg L-1 DP)也显著减少斑马鱼尾部的细胞凋亡(P < 0.05)。上述结果表明,Pb或DP单独暴露对斑马鱼均可引起神经毒性作用;但二者联合暴露对斑马鱼自主运动、触摸反应以及自由游泳活力的影响则表现为拮抗作用。
  
AuthorAffiliation
Chen Xiangping1, Huang Changjiang2, Chen Yuanhong2, Liu Bin3, Liu Cuiping3, Zhu Yaxian4, Zhang Yong1,*1. State Key Laboratory of Marine Environmental Science of China (Xiamen University), College of the Environment and Ecology, Xiamen University, Xiamen 361102, China 2. College of Public Health and Management, Wenzhou Medical University, Wenzhou 325035, China 3. Wenzhou Entry Exit Inspection and Quarantine Bureau, Wenzhou 325027, China 4. Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
英文摘要:
      Neurotoxic effects of acute exposure to lead (Pb) or Dechlorane Plus (DP), or both were investigated using zebrafish (Danio rerio) embryos. Results showed that exposure to Pb (5, 20 μg L-1) or DP (15, 60 μg L-1) alone increased spontaneous movement, decreased touch response and free-swimming activity, inhibited axonal growth of primary motoneuron and induced cell apoptosis in zebrafish embryos. Co-exposure to 20 μg L-1 Pb and 60 μg L-1 DP significantly decreased spontaneous movement (P < 0.05), enhanced touch response and free-swimming activity (P < 0.05), increased axonal length of primary motoneuron (P < 0.05) and reduced cell apoptosis in zebrafish when compared to 20 μg L-1 Pb exposure alone. Co-exposure to 5 μg L-1 Pb and 15 μg L-1 DP also significantly decreased cell apoptosis on the tail region when compared to 5 μg L-1 Pb exposure alone (P < 0.05). These results demonstrated that Pb or DP exposure alone could induce neurobehavioral toxicity in zebrafish, but Pb and DP co-exposure had antagonistic effects on spontaneous movements, touch response and free swimming activity.
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