不能将值 NULL 插入列 'id',表 'aje_website.dbo.t_web_site_access';列不允许有空值。INSERT 失败。 语句已终止。 欢迎访问《生态毒理学报》编辑部网站!

首页 | 期刊简介 | 编委会 | 投稿要求 | 化学品管理信息动态 | 学术会议 | 专辑 | 毒理学测试技术设备 | 订购本刊 | 联系我们 | English version

李恺1,2,刘树深1,2,*,屈锐1,2. 组合指数在环境混合物联合毒性研究中的初步应用[J]. 生态毒理学报, 2017, 12(3): 62-71
组合指数在环境混合物联合毒性研究中的初步应用
Application of the Combination Index in the Assessment of Combined Toxicity of Environmental Mixture
投稿时间:2017-01-14  修订日期:2017-03-02
DOI:10.7524/AJE.1673-5897.20170114001
中文关键词:  组合指数  药物组合  联合毒性  UD-Ray  置信区间
英文关键词:combination index  drug combination  combined toxicity  UD-Ray  confidence intervals
基金项目:国家自然科学基金(21377097,21177097)
作者单位
李恺1,2,刘树深1,2,*,屈锐1,2 1. 长江水环境教育部重点实验室上海 200092 2. 同济大学环境科学与工程学院上海 200092 
摘要点击次数: 33
全文下载次数: 35
中文摘要:
      化学品在实际环境中总是以组分繁杂多变的混合物形式存在,其混合物的毒性评估与预测一直是环境毒理学研究重点。在环境毒理学领域,浓度加和(concentration addition, CA)及独立作用(independent action, IA)是评估与预测化学混合物联合毒性的经典模型,一般认为CA 适用于作用模式相似的混合物体系而IA 适用于作用模式相异的混合物体系,但如何使用CA与IA 一直存在争议。组合指数(combination index, CI)是在半数效应方程基础上发展起来的不依赖于作用模式的用于混合物联合毒性评估的混合物毒性指数,具有坚实的理论基础,不仅能定性地评估毒理学相互作用,也能定量地评估相互作用的大小,已在药物组合研究中得以广泛应用,近年来已引起环境毒理学研究者兴趣。本文就组合指数及药物组合应用、进入环境毒理学领域、与CA 及IA 的关系、存在的问题等几个方面进行评述,以期推进CI 在化学混合物毒性评估与预测领域中的应用。
  
AuthorAffiliation
Li Kai1,2 , Liu Shushen1,2,* , Qu Rui1,21. Key Laboratory of Yangtze River Water Environment, Ministry of Education, Shanghai 200092, China 2. College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China
英文摘要:
      Various chemicals always exist as complex mixtures in real environment. The assessment and prediction of toxicity for chemical mixtures has been the research focus in environmental toxicology. The concentration addition (CA) and independent action (IA) are the classic additive reference models for the toxicity assessment and prediction of chemical mixture. It is generally recognized that the IA model is suitable to estimate the toxicities of the mixtures of the components showing dissimilar modes of actions (MOA), and the CA to the mixtures consisting of the chemicals with similar MOA. But how to correctly use CA and IA has been controversial for a long time. Combination index (CI) has solid theory basis for the reason that it is based on the median-effect equation and independent of the toxic MOA, and CI could qualitatively determine the toxicological interactions and quantitatively evaluate the degree of interaction. The CI has been widely used in drug combination. In recent years, CI is increasingly attracting interests of environmental toxicology researchers. In this review, the fundamental concepts and its application to drug combination and environmental toxicology field, the differences between CI and CA (or IA),and the existing problems are summarized, aiming to propel the applications of CI in mixture toxicity assessment and prediction.
查看全文  查看/发表评论  下载PDF阅读器
关闭

您是第3317623位访问者   京ICP备 09058833 号

主办单位:中国科学院生态环境研究中心     单位地址:北京市海淀区双清路18号

 服务热线:010-62941072       传真:010-62923563       邮编:100085    Email: stdlxb@rcees.ac.cn

    本系统由北京勤云科技发展有限公司设计

0463美女美女3764美女美女ktv