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-. 抗抑郁药物舍曲林和氟西汀在实验室构建的三层水生食物链中的生物积累和营养动力学研究[J]. 生态毒理学报, 2017, 12(3):
抗抑郁药物舍曲林和氟西汀在实验室构建的三层水生食物链中的生物积累和营养动力学研究
Bioaccumulation and Trophodynamics of the Antidepressants Sertraline and Fluoxetine in Laboratory-constructed, Three-level Aquatic Food Chains
  
DOI:10.7524/AJE.1673-5897.201711etc
中文关键词:  
英文关键词:Aquatic food chain  Bioaccumulation  Bioconcentration  Biomagnification  Ionizable pharmaceuticals  Selective serotonin reuptake inhibitor
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中文摘要:
      目前关于药物在水生生物中富集的报道越来越多,但人们对它们在水生食物网中的营养转移却知之甚少。选择了2种在水环境中经常被监测到的选择性5-羟色胺再摄取抑制剂(SSRIs),本文在实验室可控条件下,通过构建水生链的SSRIs暴露试验,研究了舍曲林和氟西汀的生物积累和营养动力学。在2个3层食物链中(Acer platanoides,是 Asellus aquaticus的食物,而相应地 Asellus aquaticusNotonecta glaucaPungitius pungitius的食物),随着营养级的递增,这2种可离子化的、弱碱药物均显示出较低的生物积累因子(BAFs)(这表明没有生物放大)。A. platanoidesA. aquaticusN. glaucaP. pungitius体内的舍曲林的平均BAFs分别为2200 L/kg、360 L/kg、26 L/kg和49 L/kg,氟西汀的平均BAFs分别为1300 L/kg、110 L/kg、11 L/kg和41 L/kg。生物积累因子(BAFs)的测量值等于或低于生物富集因子(BCFs)的测量值,这进一步证明了饮食的微弱影响。生物脂含量与BAFs没有正相关性,这表明其他的过程在驱动SSRI生物累积的种间差异。这里将经验参数值带入一个生物累积模型中计算,发现模拟与经验BAFs(预测r2=-0.63)之间相关性较差。综上所述,这些可离子化的药物明显缺乏生物放大作用,环境问题不应只关注较高的营养水平,而应关注在任何营养水平上有高BCFs的物种。
精选自Bostr?m, M. L., Ugge, G., J?nsson, J. ?. and Berglund, O. (2017), Bioaccumulation and trophodynamics of the antidepressants sertraline and fluoxetine in laboratory-constructed, 3-level aquatic food chains. Environmental Toxicology and Chemistry, 36: 1029–1037. doi: 10.1002/etc.3637
详情请见http://onlinelibrary.wiley.com/doi/10.1002/etc.3637/full
  
AuthorAffiliation
Boström, M. L. 1,*, Ugge, G. 1, Jönsson, J. Å. 2, Berglund, O. 11. Aquatic Ecology, Department of Biology, Lund University, Lund, Sweden 2. Centre for Analysis and Synthesis, Department of Chemistry, Lund University, Lund, Sweden
英文摘要:
      Although reports of pharmaceutical bioconcentration in aquatic organisms are increasing, less is known about trophic transfer in aquatic food webs. The bioaccumulation and trophodynamics of sertraline and fluoxetine, 2 selective serotonin reuptake inhibitors (SSRIs) frequently detected in aquatic environments, were tested by exposing constructed aquatic food chains to SSRIs under controlled laboratory conditions. Both of these ionizable, weak base pharmaceuticals showed lower bioaccumulation factors (BAFs) with increasing trophic level (i.e., no biomagnifications) in 2 3-level food chains (Acer platanoides, fed to?Asellus aquaticus, in turn fed to?Notonecta glauca?or?Pungitius pungitius). Mean sertraline BAFs in?A. platanoides, A. aquaticus, N. glauca, and?P. pungitus were 2200?L/kg, 360?L/kg, 26?L/kg, and 49?L/kg, respectively, and mean fluoxetine BAFs 1300?L/kg, 110?L/kg, 11?L/kg, and 41?L/kg, respectively. The weak influence of diet was further demonstrated by measured BAFs being equal to or lower than measured bioconcentration factors (BCFs). Organism lipid content was not positively correlated with BAFs, suggesting that other processes are driving interspecific differences in SSRI bioaccumulation. The empirically derived parameter values were introduced into a proposed bioaccumulation model, and a poor correlation was found between modeled and empirical BAFs (predicted?r2?=?–0.63). In conclusion, the apparent lack of biomagnification of these ionizable pharmaceuticals suggests that environmental concern should not necessarily focus only on higher trophic levels, but also on species showing high BCFs at any trophic level.
View more in http://onlinelibrary.wiley.com/doi/10.1002/etc.3637/full
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