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张雅晶1,缪恒锋1,2,3,*,张晓夏1,阮文权1,2,3. 市政污水处理厂二级出水消毒前后对斑马鱼幼鱼的毒性[J]. 生态毒理学报, 2018, 13(5): 208-217
市政污水处理厂二级出水消毒前后对斑马鱼幼鱼的毒性
Toxicity Effects of Chlorinated and Non-chlorinated Secondary Effluent on Juvenile Zebrafish
投稿时间:2017-12-15  修订日期:2018-03-12
DOI:10.7524/AJE.1673-5897.20171215001
中文关键词:  消毒副产物  幼年斑马鱼  氧化损伤  神经毒性  联合毒性
英文关键词:disinfection by-products  zebrafish (Danio rerio)  oxidative damage  neurotoxicity  joint toxicity
基金项目:水体污染控制与治理科技重大专项(2017ZX07203-003)
作者单位
张雅晶1,缪恒锋1,2,3,*,张晓夏1,阮文权1,2,3 1. 江南大学环境与土木工程学院无锡 214122 2. 江苏省厌氧生物技术重点实验室无锡 214122 3. 江苏省水处理技术与材料协同创新中心苏州 215009 
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中文摘要:
      为了探究消毒副产物(DBPs)的氧化损伤和神经毒性作用,选择幼年斑马鱼作为模式生物,研究了市政污水处理厂二级出水和经次氯酸钠(NaClO)消毒后的二级出水对斑马鱼体内过氧化氢酶(CAT)活性、丙二醛(MDA)含量和乙酰胆碱酯酶(AchE)活性的影响。结果表明,暴露时间达到10 d时,MDA含量显著高于对照,且消毒后MDA含量增幅(91.43%)显著高于消毒前(44.36%);暴露时间达到15 d时,CAT活性被显著抑制,且消毒后抑制率(40.22%)显著高于消毒前(15.56%);说明消毒后暴露组对斑马鱼的氧化损伤强于消毒前。另外,消毒前后污水对AchE活性抑制率分别为38.49%和48.50%,说明消毒后污水对斑马鱼的神经毒性更大。因此,经NaClO消毒后的市政污水处理厂二级出水中DBPs对斑马鱼的抗氧化防御系统和神经系统具有潜在影响。
  
AuthorAffiliation
Zhang Yajing1, Miao Hengfeng 1,2,3,*, Zhang Xiaoxia1, Ruan Wenquan1,2,31. School of Environmental & Civil Engineering, Jiangnan University, Wuxi 214122, China 2. Jiangsu Key Laboratory of Anaerobic Biotechnology, Wuxi 214122, China 3. Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou 215009, China
英文摘要:
      Juvenile zebrafish was chosen as a model organism to explore the oxidative damage and neurotoxicity of disinfection by-products (DBPs). The juvenile zebrafish were exposed to the chlorinated and non-chlorinated secondary effluents to test their subacute toxicity. The activities of catalase (CAT) and acetylcholinesterase (AchE) as well as malondialdehyde (MDA) contents in the exposed zebrafish were analyzed. Results showed that the MDA contents in the exposed groups were significantly higher than those in the control, after 10-days of exposure. The increase of MDA content in the chlorinated group (91.43%) was much higher than those in the non-chlorinated group (44.36%). Moreover, CAT activities in the exposed groups were dramatically inhibited after 10-days of exposure. The chlorinated group (40.22%) exerted obviously higher inhibition than non-chlorinated group (15.56%) did. Results indicated that the chlorinated secondary effluents had greater oxidative toxicity to zebrafish. In addition, the chlorinated secondary effluents also displayed higher AchE inhibition (48.50%) than the non-chlorinated group (38.49%), demonstrating the chlorinated group had greater neurotoxicity to zebrafish. In all, the DBPs formation during the secondary effluent chlorination has the potential impact on antioxidant defense system and nervous system of zebrafish.
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