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-. 湖鲟(Acipenser fulvescens)早期生命阶段对2,3,7,8-四氯二苯并-p-二恶英和3,3'4,4'5-五氯联苯的敏感性研究[J]. 生态毒理学报, 2017, 12(3):
湖鲟(Acipenser fulvescens)早期生命阶段对2,3,7,8-四氯二苯并-p-二恶英和3,3'4,4'5-五氯联苯的敏感性研究
Sensitivity of Lake Sturgeon (Acipenser fulvescens) Early Life Stages to 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 3,3’,4,4’,5-Pentachlorobiphenyl
  
DOI:10.7524/AJE.1673-5897.201712etc
中文关键词:  
英文关键词:Polychlorinated biphenyls (PCBs)  Sturgeon  Early-life stage  Developmental toxicity  Dioxins
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中文摘要:
      自20世纪中叶以来,五大湖区的水生食物网就已受到多氯联苯化合物(PCBs)的污染。对于长寿命鱼类,如湖鲟(Acipenser fulvescens),由于缺乏该物种的相对敏感性信息,一直无法确定其PCB暴露的风险。本文的研究目标就是评估湖鲟早期生命阶段对3,3'4,4'5-五氯联苯(PCB-126)或2,3,7,8-四氯二苯并-p-二恶英(TCDD)暴露的敏感性。死亡率、生长、形态和组织病理学、游泳能力和活动水平都被用作评估终点。心包和卵黄囊水肿、管状心脏、卵黄囊出血和体长较小是TCDD和PCB-126暴露中最常见的病理症状,早在受精4 d后就开始出现,其中许多的病理都以一种剂量依赖的方式发生。湖鲟体内PCB-126和TCDD的半致死剂量分别为5.4 ng/g egg(95%置信区间,3.9-7.4 ng/g egg)和0.61 ng/g egg (0.47-0.82 ng/g egg)。由此产生的PCB-126的相对强度因子(0.11)远大于世界卫生组织对鱼的估计值(毒性当量因子=0.005),这表明目前的风险评估可能低估了PCB对湖鲟的毒性。在受精60 d后,从半致死剂量中幸存的湖鲟的游泳活性和耐力均有所下降。阈值和半数效应毒性值表明,与在北美发现的另一种鲟鱼属Scaphirhynchu相比,湖鲟对PCB和TCDD更为敏感。事实上,在大湖区和其他地方的湖鲟种群都容易受到PCB/ TCDD诱导,使胚胎发育受到影响,游泳能力下降。
精选自Tillitt, D. E., Buckler, J. A., Nicks, D. K., Candrl, J. S., Claunch, R. A., Gale, R. W., Puglis, H. J., Little, E. E., Linbo, T. L. and Baker, M. (2017), Sensitivity of lake sturgeon (Acipenser fulvescens) early life stages to 2,3,7,8-tetrachlorodibenzo-P-dioxin and 3,3′,4,4′,5-pentachlorobiphenyl. Environmental Toxicology and Chemistry, 36: 988–998. doi: 10.1002/etc.3614
详情请见http://onlinelibrary.wiley.com/doi/10.1002/etc.3614/full
  
AuthorAffiliation
Donald E. Tillitt 1,*, Justin A. Buckler 2, Diane K. Nicks 1, James S. Candrl 1, Rachel A. Claunch 1, Robert W. Gale 1, Holly J. Puglis 1, Edward E. Little 1, Tiffany L. Linbo 3, Mary Baker 41. Columbia Environmental Research Center, US Geological Survey, Columbia, Missouri, USA 2. Five Rivers Services Corporation, Columbia Environmental Research Center, Columbia, Missouri, USA 3. Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, Seattle, Washington, USA 4. Office of Response and Restoration, National Oceanic and Atmospheric Administration, Seattle, Washington, USA
英文摘要:
      The aquatic food web of the Great Lakes has been contaminated with polychlorinated biphenyls (PCBs) since the mid-20th century. Threats of PCB exposures to long-lived species of fish, such as lake sturgeon (Acipenser fulvescens), have been uncertain because of a lack of information on the relative sensitivity of the species. The objective of the present study was to evaluate the sensitivity of early–life stage lake sturgeon to 3,3′,4,4′,5-pentachlorobiphenyl (PCB-126) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. Mortality, growth, morphological and tissue pathologies, swimming performance, and activity levels were used as assessment endpoints. Pericardial and yolk sac edema, tubular heart, yolk sac hemorrhaging, and small size were the most commonly observed pathologies in both TCDD and PCB-126 exposures, beginning as early as 4 d postfertilization, with many of these pathologies occurring in a dose-dependent manner. Median lethal doses for PCB-126 and TCDD in lake sturgeon were 5.4?ng/g egg (95% confidence interval, 3.9–7.4?ng/g egg) and 0.61?ng/g egg (0.47–0.82?ng/g egg), respectively. The resulting relative potency factor for PCB-126 (0.11) was greater than the World Health Organization estimate for fish (toxic equivalency factor?=?0.005), suggesting that current risk assessments may underestimate PCB toxicity toward lake sturgeon. Swimming activity and endurance were reduced in lake sturgeon survivors from the median lethal doses at 60?d postfertilization. Threshold and median toxicity values indicate that lake sturgeon, like other?Acipenser?species, are more sensitive to PCB and TCDD than the other genus of sturgeon,?Scaphirhynchus, found in North America. Indeed, lake sturgeon populations in the Great Lakes and elsewhere are susceptible to PCB/TCDD-induced developmental toxicity in embryos and reductions in swimming performance.
View more in http://onlinelibrary.wiley.com/doi/10.1002/etc.3614/full
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