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-. 评估可离子化有机化合物的生物累积潜力:当前的认知和研究的重点[J]. 生态毒理学报, 2017, 12(3):
评估可离子化有机化合物的生物累积潜力:当前的认知和研究的重点
Assessing the Bioaccumulation Potential of Ionizable Organic Compounds: Current Knowledge and Research Priorities
  
DOI:10.7524/AJE.1673-5897.201714etc
中文关键词:  
英文关键词:Bioaccumulation  Toxicokinetics  Ecological risk assessment  Ionizable organic chemical (IOC)
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中文摘要:
      本研究的目的是回顾目前关于可离子化有机化合物(IOCs)的生物累积潜力的认知,重点讨论鱼类经验数据的有效性。IOCs在鱼体内的生物积累潜力可以很好地表征为:依赖pH的鳃摄取和排泄,肠道吸收和磷脂吸附(膜-水分区)。关键的挑战包括缺乏关于IOCs生物转化和血浆结合的经验数据。鱼拥有多种蛋白质,可以在细胞膜上传输IOCs。然而,除了少数情况下,这种传输对环境污染物的吸收和积累的意义是未知的。本文提出了2个研究案例。第一个描述了pH值和生物转化对有机酸和碱的生物富集的建模作用,而第二个则采用了一个更新的模型来研究导致全氟烷基酸积累的因素。全氟化烷基酸个案研究是值得关注的,因为它说明了膜转运蛋白在肾脏中可能具有的重要性,并强调了交叉比对方法(read-across approaches)的潜在价值。认识到当前需要对IOCs进行生物累积危害评估和生态风险评估,作者提供了一个分层策略,从保守的假设(模型和相关数据)到需要化学特定信息的更复杂的模型。
精选自Armitage, J. M., Erickson, R. J., Luckenbach, T., Ng, C. A., Prosser, R. S., Arnot, J. A., Schirmer, K. and Nichols, J. W. (2017), Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities. Environmental Toxicology and Chemistry, 36: 882–897. doi: 10.1002/etc.3680
详情请见http://onlinelibrary.wiley.com/doi/10.1002/etc.3680/full
  
AuthorAffiliation
James M. Armitage 1,*, Russell J. Erickson 2, Till Luckenbach 3, Carla A. Ng 4, Ryan S. Prosser 5, Jon A. Arnot 1,6, Kristin Schirmer 7,8,9, John W. Nichols 21.Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada 2. Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA 3. Department Bioanalytical Ecotoxicology, UFZ–Helmholtz Centre for Environmental Research, Leipzig, Germany 4. Department of Civil and Environmental Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 5. School of Environmental Sciences, University of Guelph, Guelph, Ontario, Canada 6. ARC Arnot Research and Consulting, Toronto, Ontario, Canada 7. Eawag, Department of Environmental Toxicology, Swiss Federal Institute of Aquatic Science and Technology, Duebendorf, Switzerland 8. School of Architecture, Civil and Environmental Engineering, EPFL, Lausanne, Switzerland 9. Institute of Biogeochemistry and Pollutant Dynamics, ETH Zurich, Zurich, Switzerland
英文摘要:
      The objective of the present study was to review the current knowledge regarding the bioaccumulation potential of ionizable organic compounds (IOCs), with a focus on the availability of empirical data for fish. Aspects of the bioaccumulation potential of IOCs in fish that can be characterized relatively well include the pH dependence of gill uptake and elimination, uptake in the gut, and sorption to phospholipids (membrane–water partitioning). Key challenges include the lack of empirical data for biotransformation and binding in plasma. Fish possess a diverse array of proteins that may transport IOCs across cell membranes. Except in a few cases, however, the significance of this transport for uptake and accumulation of environmental contaminants is unknown. Two case studies are presented. The first describes modeled effects of pH and biotransformation on the bioconcentration of organic acids and bases, while the second employs an updated model to investigate factors responsible for accumulation of perfluorinated alkyl acids. The perfluorinated alkyl acid case study is notable insofar as it illustrates the likely importance of membrane transporters in the kidney and highlights the potential value of read-across approaches. Recognizing the current need to perform bioaccumulation hazard assessments and ecological and exposure risk assessment for IOCs, the authors provide a tiered strategy that progresses (as needed) from conservative assumptions (models and associated data) to more sophisticated models requiring chemical-specific information.
View more in http://onlinelibrary.wiley.com/doi/10.1002/etc.3680/full
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