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郄明丽1,2,李志慧1,2,张伟伟1,高言1,2,冯志远1,2,张建海1,2,*. 羧基化多壁碳纳米管对雌性小鼠卵泡发育的影响[J]. 生态毒理学报, 2018, 13(6): 369-374
羧基化多壁碳纳米管对雌性小鼠卵泡发育的影响
Effects of MWCNTs-COOH on Follicular Development in Female Mice
投稿时间:2018-09-04  修订日期:2018-11-08
DOI:
中文关键词:  羧基化多壁碳纳米管  雌性小鼠  生殖毒性  组织形态学变化
英文关键词:MWCNTs-COOH  female mice  reproductive toxicity  morphological changes
基金项目:山西省研究生创新项目(20143057);山西省回国留学人员科研资助项目(2017071)
作者单位
郄明丽1,2,李志慧1,2,张伟伟1,高言1,2,冯志远1,2,张建海1,2,* 1. 山西农业大学动物科技学院太谷 030801 2. 生态畜牧与环境兽医学山西省重点实验室太谷 030801 
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中文摘要:
      碳纳米管(carbon nanotubes, CNTs)作为一种新形式的结晶碳,在工业及医药领域具有非常广阔的应用前景。本研究采用水溶性较好的羧基化多壁碳纳米管(MWCNTs-COOH)为研究对象,探索功能化多壁碳纳米管对小鼠卵巢发育的影响。将羧基化多壁碳纳米管溶解在含0.5% Tween-20的磷酸盐缓冲溶液(PBS)中,对实验小鼠按照2.5, 5, 10 mg·kg-1进行持续64 d的灌胃处理。处理结束后通过透射电子显微镜和HE染色观察卵巢组织的形态学变化。结果显示,碳纳米管确实进入了小鼠卵巢中。同时,随着MWCNTs-COOH暴露的增加,雌性小鼠卵泡数量显著减少,而雌性小鼠卵泡的形态结构并无明显影响。
  
AuthorAffiliation
Qie Mingli1,2, Li Zhihui1,2, Zhang Weiwei1, Gao Yan1,2, Feng Zhiyuan1,2, Zhang Jianhai1,2,*1. College of Animal Science and Technology, Shanxi Agricultural University, Taigu, 030801, China 2. Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Taigu, 030801, China
英文摘要:
      As a new form of crystalline carbon, carbon nanotubes (CNTs) has a great application prospect in industry and medicine. Carboxylation functionalized multi-walled carbon nanotubes (MWCNTs-COOH) was employed, in this study, to investigate the effects of MWCNTs on follicular development of female mice based on its dissolving characters in water. The mice were administrated intragastrically with 0, 2.5, 5 and 10 mg·kg-1 body weight MWCNTs-COOH (0.5% Tween-20 phosphate buffer saline solution) for continuous 64 days. The morphological changes of ovarian tissue were observed by hematoxylin and eosin (H&E) staining and TEM. The results showed that MWCNTs-COOH entered into the ovary and decreased significantly the follicle number in mice exposed to MWCNTs-COOH. However, no obvious changes on the morphological structure of female mouse follicles were observed.
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