脂质组学在环境领域中的应用

熊倩; 胡立新; 蒋宇霞; 应光国

doi:10.7524/AJE.1673-5897.20180203002

脂质组学在环境领域中的应用

1. 中国科学院广州地球化学研究所有机地球化学国家重点实验室, 广州 510640;

2. 中国科学院大学, 北京 100049;

3. 华南师范大学环境研究院广东省化学品污染与环境安全重点实验室 & 环境理论化学教育部重点实验室, 广州 510006

作者简介: 熊倩(1988-),女,博士研究生,研究方向为污染物化学与生态毒理,Email:xiongqian010@163.com

通讯作者: 应光国, E-mail: guangguo.ying@m.scnu.edu.cn

基金项目:

广东省应用型科技研发专项(2015B020235012)

中图分类号: X171.5

Application of Lipidomics in Environmental Research

1. Skate Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China;

2. University of Chinese Academy of Sciences, Beijing 100049, China;

3. SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety&MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, China

Corresponding author: Ying Guangguo, guangguo.ying@m.scnu.edu.cn

Fund Project:

摘要: 脂质是生物体内重要的组成物质之一,具有多种重要的生物学功能。脂质组学作为代谢组学的一个重要分支,主要通过研究生物体内脂质化合物及脂质代谢谱的变化,进而鉴定生物标志物,分析相关代谢通路,阐明生物体响应外界刺激的机制。随着分析技术的不断进步,尤其是色谱和质谱技术的引入,极大地推动了脂质组学研究的发展,并扩展了其应用范围。本文介绍了脂质组学的研究方法及其在环境领域中的应用前景,重点讨论了脂质组学及多组学联用技术在环境胁迫耐受性及环境污染物毒性评价中的应用。

Abstract: Lipid is one of the important biological components, and it plays multiple critical roles in cellular functions. As a branch of metabolomics, lipidomics is aimed at specific analysis of the alteration of lipid metabolism, identification of lipid biomarkers, and understanding the pathways that respond to physiological perturbation. The advance of modern analytical technology, especially with the use of mass spectrometry and chromatography in the research, has significantly accelerated the development of lipidomics and broadened its application in recent years. Here we introduce the methodology of lipidomics and its application in environmental research fields. We mainly discussed the application of lipidomics and multiple omics technologies in the response of organisms to environmental stress and in the toxicological evaluation of environmental contaminants.

Key words:

脂质组学在环境领域中的应用

通讯作者: 应光国, E-mail: guangguo.ying@m.scnu.edu.cn

作者简介: 熊倩(1988-),女,博士研究生,研究方向为污染物化学与生态毒理,Email:xiongqian010@163.com
1. 中国科学院广州地球化学研究所有机地球化学国家重点实验室, 广州 510640;

2. 中国科学院大学, 北京 100049;

3. 华南师范大学环境研究院广东省化学品污染与环境安全重点实验室 & 环境理论化学教育部重点实验室, 广州 510006

收稿日期: 2018-02-03

基金项目:

广东省应用型科技研发专项(2015B020235012)

关键词:

Application of Lipidomics in Environmental Research

Corresponding author: Ying Guangguo, guangguo.ying@m.scnu.edu.cn

1. Skate Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China;

2. University of Chinese Academy of Sciences, Beijing 100049, China;

Received Date: 2018-02-03

Fund Project:

Keywords:

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