| United Nations Environment Programme (UNEP). Global chemicals outlook:Towards sound management of chemicals[R]. Nairobi, Kenya:UNEP, 2013 |
| Rappaport S M, Smith M T. Environment and disease risks[J]. Science, 2010, 330(6003):460-461 |
| Gruber K. Cleaning up pollutants to protect future health[J]. Nature, 2018, 555(7695):S20-S22 |
| Cicero C E, Mostile G, Vasta R, et al. Metals and neurodegenerative diseases. A systematic review[J]. Environmental Research, 2017, 159:82-94 |
| Backhaus T, Faust M. Predictive environmental risk assessment of chemical mixtures:A conceptual framework[J]. Environmental Science&Technology, 2012, 46(5):2564-2573 |
| Syberg K, Hansen S F. Environmental risk assessment of chemicals and nanomaterials:The best foundation for regulatory decision-making?[J]. Science of the Total Environment, 2016, 541:784-794 |
| Farmahin R, Williams A, Kuo B, et al. Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment[J]. Archives of Toxicology, 2017, 91(5):2045-2065 |
| Moffat I, Chepelev N, Labib S, et al. Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water[J]. Critical Reviews in Toxicology, 2015, 45(1):1-43 |
| Waters M D, Fostel J M. Toxicogenomics and systems toxicology:Aims and prospects[J]. Nature Reviews Genetics, 2004, 5(12):936-948 |
| Aardema M J, MacGregor J T. Toxicology and genetic toxicology in the new era of "toxicogenomics":Impact of "-omics" technologies[J]. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2002, 499(1):13-25 |
| Zhang X W, Xia P, Wang P P, et al. Omics advances in ecotoxicology[J]. Environmental Science&Technology, 2018, 52(7):3842-3851 |
| Xia P, Zhang X W, Xie Y W, et al. Functional toxicogenomic assessment of triclosan in human HepG2 cells using genome-wide CRISPR-Cas9 screening[J]. Environmental Science&Technology, 2016, 50(19):10682-10692 |
| Lujan H, Romer E, Salisbury R, et al. Determining the biological mechanisms of action for environmental exposures:Applying CRISPR/Cas9 to toxicological assessments[J]. Toxicological Sciences:An Official Journal of the Society of Toxicology, 2020, 175(1):5-18 |
| de Jong K, Vonk J M, Imboden M, et al. Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure[J]. Respiratory Research, 2017, 18(1):142 |
| Smith B M, Traboulsi H, Austin J H M, et al. Human airway branch variation and chronic obstructive pulmonary disease[J]. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115(5):E974-E981 |
| Khreis H, Kelly C, Tate J, et al. Exposure to traffic-related air pollution and risk of development of childhood asthma:A systematic review and meta-analysis[J]. Environment International, 2017, 100:1-31 |
| Thomas D. Gene:Environment-wide association studies:Emerging approaches[J]. Nature Reviews Genetics, 2010, 11(4):259-272 |
| Sepand M R, Aliomrani M, Hasani-Nourian Y, et al. Mechanisms and pathogenesis underlying environmental chemical-induced necroptosis[J]. Environmental Science and Pollution Research International, 2020, 27(30):37488-37501 |
| Rodgers K M, Udesky J O, Rudel R A, et al. Environmental chemicals and breast cancer:An updated review of epidemiological literature informed by biological mechanisms[J]. Environmental Research, 2018, 160:152-182 |
| Shen H, McHale C M, Smith M T, et al. Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9[J]. Mutation Research Reviews in Mutation Research, 2015, 764:31-42 |
| Jo W J, Loguinov A, Wintz H, et al. Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAⅢ) and arsenite (AsⅢ) in yeast[J]. Toxicological Sciences:An Official Journal of the Society of Toxicology, 2009, 111(2):424-436 |
| Zhou Y X, Zhu S Y, Cai C Z, et al. High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells[J]. Nature, 2014, 509(7501):487-491 |
| Shortt K, Heruth D P, Zhang N N, et al. Identification of novel regulatory genes in APAP induced hepatocyte toxicity by a genome-wide CRISPR-Cas9 screen[J]. Scientific Reports, 2019, 9(1):1396 |
| Guan M, Xia P, Tian M M, et al. Molecular fingerprints of conazoles via functional genomic profiling of Saccharomyces cerevisiae [J]. Toxicology in Vitro:An International Journal Published in Association with BIBRA, 2020, 69:104998 |
| Chow R D, Chen S D. Cancer CRISPR screens in vivo [J]. Trends in Cancer, 2018, 4(5):349-358 |
| Shan G. RNA interference as a gene knockdown technique[J]. The International Journal of Biochemistry&Cell Biology, 2010, 42(8):1243-1251 |
| Zhang F, Wen Y, Guo X. CRISPR/Cas9 for genome editing:Progress, implications and challenges[J]. Human Molecular Genetics, 2014, 23(R1):R40-R46 |
| Shalem O, Sanjana N E, Hartenian E, et al. Genome-scale CRISPR-Cas9 knockout screening in human cells[J]. Science, 2014, 343(6166):84-87 |
| Cenik C, Cenik E S, Byeon G W, et al. Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans[J]. Genome Research, 2015, 25(11):1610-1621 |
| Reczek C R, Birsoy K, Kong H, et al. A CRISPR screen identifies a pathway required for paraquat-induced cell death[J]. Nature Chemical Biology, 2017, 13(12):1274-1279 |
| Bassett D E, Boguski M S, Hieter P. Yeast genes and human disease[J]. Nature, 1996, 379(6566):589-590 |
| Scherens B, Goffeau A. The uses of genome-wide yeast mutant collections[J]. Genome Biology, 2004, 5(7):229 |
| Steinmetz L M, Scharfe C, Deutschbauer A M, et al. Systematic screen for human disease genes in yeast[J]. Nature Genetics, 2002, 31(4):400-404 |
| Yamazoe M, Sonoda E, Hochegger H, et al. Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40[J]. DNA Repair, 2004, 3(8-9):1175-1185 |
| Ji K, Kogame T, Choi K, et al. A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants[J]. Environmental Health Perspectives, 2009, 117(11):1737-1744 |
| Ooka M, Takazawa H, Takeda S, et al. Cytotoxic and genotoxic profiles of benzo[a]pyrene and N-nitrosodimethylamine demonstrated using DNA repair deficient DT40 cells with metabolic activation[J]. Chemosphere, 2016, 144:1901-1907 |
| Kotecki M, Reddy P S, Cochran B H. Isolation and characterization of a near-haploid human cell line[J]. Experimental Cell Research, 1999, 252(2):273-280 |
| Pettitt S J, Rehman F L, Bajrami I, et al. A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity[J]. PLoS One, 2013, 8(4):e61520 |
| Duncan L M, Timms R T, Zavodszky E, et al. Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells[J]. PLoS One, 2012, 7(6):e39651 |
| Leeb M, Wutz A. Derivation of haploid embryonic stem cells from mouse embryos[J]. Nature, 2011, 479(7371):131-134 |
| Wolters N M, MacKeigan J P. From sequence to function:Using RNAi to elucidate mechanisms of human disease[J]. Cell Death&Differentiation, 2008, 15(5):809-819 |
| Root D E, Hacohen N, Hahn W C, et al. Genome-scale loss-of-function screening with a lentiviral RNAi library[J]. Nature Methods, 2006, 3(9):715-719 |
| Mohr S E, Smith J A, Shamu C E, et al. RNAi screening comes of age:Improved techniques and complementary approaches[J]. Nature Reviews Molecular Cell Biology, 2014, 15(9):591-600 |
| Zheng Q P, Cai X H, Tan M H, et al. Precise gene deletion and replacement using the CRISPR/Cas9 system in human cells[J]. BioTechniques, 2014, 57(3):115-124 |
| Costanzo M C, Hogan J D, Cusick M E, et al. The yeast proteome database (YPD) and Caenorhabditis elegans proteome database (WormPD):Comprehensive resources for the organization and comparison of model organism protein information[J]. Nucleic Acids Research, 2000, 28(1):73-76 |
| Parsons A B, Geyer R, Hughes T R, et al. Yeast genomics and proteomics in drug discovery and target validation[J]. Progress in Cell Cycle Research, 2003, 5:159-166 |
| O'Connor S T, Lan J Q, North M, et al. Genome-wide functional and stress response profiling reveals toxic mechanism and genes required for tolerance to benzo[a]pyrene in S. cerevisiae [J]. Frontiers in Genetics, 2012, 3:316 |
| de Graaf B, Clore A, McCullough A K. Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA-protein crosslinks[J]. DNA Repair, 2009, 8(10):1207-1214 |
| Ren X F, Lim S, Ji Z Y, et al. Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells[J]. PLoS One, 2011, 6(1):e14546 |
| Ren X F, Aleshin M, Jo W J, et al. Involvement of N-6 adenine-specific DNA methyltransferase 1(N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity[J]. Environmental Health Perspectives, 2011, 119(6):771-777 |
| Buerstedde J M, Takeda S. Increased ratio of targeted to random integration after transfection of chicken B cell lines[J]. Cell, 1991, 67(1):179-188 |
| Evans T J, Yamamoto K N, Hirota K, et al. Mutant cells defective in DNA repair pathways provide a sensitive high-throughput assay for genotoxicity[J]. DNA Repair, 2010, 9(12):1292-1298 |
| Mizutani A, Okada T, Shibutani S, et al. Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair-deficient cells[J]. Cancer Research, 2004, 64(9):3144-3147 |
| Ji K, Choi K, Giesy J P, et al. Genotoxicity of several polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDEs, and their mechanisms of toxicity[J]. Environmental Science&Technology, 2011, 45(11):5003-5008 |
| Andersson B S, Beran M, Pathak S, et al. pH-positive chronic myeloid leukemia with near-haploid conversion in vivo and establishment of a continuously growing cell line with similar cytogenetic pattern[J]. Cancer Genetics and Cytogenetics, 1987, 24(2):335-343 |
| Carette J E, Raaben M, Wong A C, et al. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1[J]. Nature, 2011, 477(7364):340-343 |
| Birsoy K, Wang T, Possemato R, et al. MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors[J]. Nature Genetics, 2013, 45(1):104-108 |
| Shen H, McHale C M, Haider S I, et al. Identification of genes that modulate susceptibility to formaldehyde and imatinib by functional genomic screening in human haploid KBM7 cells[J]. Toxicological Sciences:An Official Journal of the Society of Toxicology, 2016, 154(1):194 |
| Lee C C, Carette J E, Brummelkamp T R, et al. A reporter screen in a human haploid cell line identifies CYLD as a constitutive inhibitor of NF-κ B[J]. PLoS One, 2013, 8(7):e70339 |
| Elling U, Taubenschmid J, Wirnsberger G, et al. Forward and reverse genetics through derivation of haploid mouse embryonic stem cells[J]. Cell Stem Cell, 2011, 9(6):563-574 |
| Li W, Shuai L, Wan H F, et al. Androgenetic haploid embryonic stem cells produce live transgenic mice[J]. Nature, 2012, 490(7420):407-411 |
| Carette J E, Pruszak J, Varadarajan M, et al. Generation of iPSCs from cultured human malignant cells[J]. Blood, 2010, 115(20):4039-4042 |
| Rana T M. Illuminating the silence:Understanding the structure and function of small RNAs[J]. Nature Reviews Molecular Cell Biology, 2007, 8(1):23-36 |
| Willingham A T, Deveraux Q L, Hampton G M, et al. RNAi and HTS:Exploring cancer by systematic loss-of-function[J]. Oncogene, 2004, 23(51):8392-8400 |
| Fennell M, Xiang Q, Hwang A, et al. Impact of RNA-guided technologies for target identification and deconvolution[J]. Journal of Biomolecular Screening, 2014, 19(10):1327-1337 |
| Park H R, Oh R, Wagner P, et al. New Insights into Cellular Stress Responses to Environmental Metal Toxicants[M]//Galluzzi L. Ed. International Review of Cell and Molecular Biology. Elsevier B.V., 2017, 331:55-82 |
| Oh R S, Pan W C, Yalcin A, et al. Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2(SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress[J]. The Journal of Biological Chemistry, 2012, 287(8):6025-6034 |
| Berns K, Bernards R. Understanding resistance to targeted cancer drugs through loss of function genetic screens[J]. Drug Resistance Updates, 2012, 15(5-6):268-275 |
| Swanton C, Marani M, Pardo O, et al. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs[J]. Cancer Cell, 2007, 11(6):498-512 |
| Singel S M, Cornelius C, Batten K, et al. A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer[J]. Clinical Cancer Research:An Official Journal of the American Association for Cancer Research, 2013, 19(8):2061-2070 |
| Schmidt E E, Pelz O, Buhlmann S, et al. GenomeRNAi:A database for cell-based and in vivo RNAi phenotypes, 2013 update[J]. Nucleic Acids Research, 2013, 41(Database issue):D1021-D1026 |
| Ngo V N, Davis R E, Lamy L, et al. A loss-of-function RNA interference screen for molecular targets in cancer[J]. Nature, 2006, 441(7089):106-110 |
| Bassik M C, Lebbink R J, Churchman L S, et al. Rapid creation and quantitative monitoring of high coverage shRNA libraries[J]. Nature Methods, 2009, 6(6):443-445 |
| Cong L, Ran F A, Cox D, et al. Multiplex genome engineering using CRISPR/Cas systems[J]. Science, 2013, 339(6121):819-823 |
| Jinek M, East A, Cheng A, et al. RNA-programmed genome editing in human cells[J]. eLife, 2013, 2:e00471 |
| Blanchard A P, Hood L. Sequence to array:Probing the genome's secrets[J]. Nature Biotechnology, 1996, 14(13):1649 |
| Sander J D, Joung J K. CRISPR-Cas systems for editing, regulating and targeting genomes[J]. Nature Biotechnology, 2014, 32(4):347-355 |
| Wang T, Wei J J, Sabatini D M, et al. Genetic screens in human cells using the CRISPR-Cas9 system[J]. Science, 2014, 343(6166):80-84 |
| Sanjana N E, Shalem O, Zhang F. Improved vectors and genome-wide libraries for CRISPR screening[J]. Nature Methods, 2014, 11(8):783-784 |
| Koike-Yusa H, Li Y L, Tan E P, et al. Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library[J]. Nature Biotechnology, 2014, 32(3):267-273 |
| Joung J, Konermann S, Gootenberg J S, et al. Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening[J]. Nature Protocols, 2017, 12(4):828-863 |
| Bredesen D E, Rao R V, Mehlen P. Cell death in the nervous system[J]. Nature, 2006, 443(7113):796-802 |
| Baltazar M T, Dinis-Oliveira R J, de Lourdes Bastos M, et al. Pesticides exposure as etiological factors of Parkinson's Disease and other neurodegenerative diseases:A mechanistic approach[J]. Toxicology Letters, 2014, 230(2):85-103 |
| Dinwiddie M T, Terry P D, Chen J G. Recent evidence regarding triclosan and cancer risk[J]. International Journal of Environmental Research and Public Health, 2014, 11(2):2209-2217 |
| Kalloo G, Calafat A M, Chen A M, et al. Early life triclosan exposure and child adiposity at 8 Years of age:A prospective cohort study[J]. Environmental Health:A Global Access Science Source, 2018, 17(1):24 |
| Sobh A, Loguinov A, Stornetta A, et al. Genome-wide CRISPR screening identifies the tumor suppressor candidate OVCA2 as a determinant of tolerance to acetaldehyde[J]. Toxicological Sciences:An Official Journal of the Society of Toxicology, 2019, 169(1):235-245 |
| Sobh A, Loguinov A, Yazici G N, et al. Functional profiling identifies determinants of arsenic trioxide cellular toxicity[J]. Toxicological Sciences:An Official Journal of the Society of Toxicology, 2019, 169(1):108-121 |
| Panganiban R A, Park H R, Sun M Y, et al. Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis[J]. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116(27):13384-13393 |
| Liao Y J, Hao Y M, Chen H, et al. Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death[J]. Protein&Cell, 2015, 6(6):434-442 |
| Gogvadze V, Orrenius S, Zhivotovsky B. Analysis of mitochondrial dysfunction during cell death[J]. Methods in Molecular Biology, 2015, 1264:385-393 |
| Braun R J. Mitochondrion-mediated cell death:Dissecting yeast apoptosis for a better understanding of neurodegeneration[J]. Frontiers in Oncology, 2012, 2:182 |
| Tangamornsuksan W, Lohitnavy O, Sruamsiri R, et al. Paraquat exposure and Parkinson's Disease:A systematic review and meta-analysis[J]. Archives of Environmental&Occupational Health, 2019, 74(5):225-238 |
| Orth M. Mitochondrial involvement in Parkinson's Disease[J]. Neurochemistry International, 2002, 40(6):533-541 |
| Coelho M A, de Braekeleer E, Firth M, et al. CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs[J]. Nature Communications, 2020, 11(1):4132 |
| Concordet J P, Haeussler M. CRISPOR:Intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens[J]. Nucleic Acids Research, 2018, 46(W1):W242-W245 |
| Liu M S, Gong S Z, Yu H H, et al. Engineered CRISPR/Cas9 enzymes improve discrimination by slowing DNA cleavage to allow release of off-target DNA[J]. Nature Communications, 2020, 11(1):3576 |
| Liu Y, Chang J S, Yang C F, et al. Genome-wide CRISPR-Cas9 screening in Bombyx mori reveals the toxicological mechanisms of environmental pollutants, fluoride and cadmium[J]. Journal of Hazardous Materials, 2021, 410:124666 |
| Chen Y C, Tsai Y H, Wang C C, et al. Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes[J]. Scientific Reports, 2021, 11:5022 |
| Ren X W, Wen W, Fan X Y, et al. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas[J]. Cell, 2021, 184(23):5838 |