Gronemeyer H, Gustafsson J Å, Laudet V. Principles for modulation of the nuclear receptor superfamily[J]. Nature Reviews Drug Discovery, 2004, 3(11): 950-964
Tata J R. Signalling through nuclear receptors[J]. Nature Reviews Molecular Cell Biology, 2002, 3(9): 702-710
Kliewer S A. The nuclear pregnane X receptor regulates xenobiotic detoxification[J]. The Journal of Nutrition, 2003, 133(7): 2444S-2447S
Creusot N, Kinani S, Balaguer P, et al. Evaluation of an hPXR reporter gene assay for the detection of aquatic emerging pollutants: Screening of chemicals and application to water samples[J]. Analytical and Bioanalytical Chemistry, 2010, 396(2): 569-583
Xiang D D, Wang Q W. PXR-mediated organophorous flame retardant tricresyl phosphate effects on lipid homeostasis[J]. Chemosphere, 2021, 284: 131250
Negi C K, Bajard L, Kohoutek J, et al. An adverse outcome pathway based in vitro characterization of novel flame retardants-induced hepatic steatosis[J]. Environmental Pollution, 2021, 289: 117855
Liu J W, Hernandez R, Li X C, et al. Pregnane X receptor mediates atherosclerosis induced by dicyclohexyl phthalate in LDL receptor-deficient mice[J]. Cells, 2022, 11(7): 1125
Kojima H, Sata F, Takeuchi S, et al. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays[J]. Toxicology, 2011, 280(3): 77-87
Delfosse V, Dendele B, Huet T, et al. Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds[J]. Nature Communications, 2015, 6: 8089
Delfosse V, Huet T, Harrus D, et al. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures[J]. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118(1): e2020551118
Paguio A, Stecha P, Wood K V, et al. Improved dual-luciferase reporter assays for nuclear receptors[J]. Current Chemical Genomics, 2010, 4: 43-49
Sui Y P, Ai N, Park S H, et al. Bisphenol A and its analogues activate human pregnane X receptor[J]. Environmental Health Perspectives, 2012, 120(3): 399-405
Kojima H, Takeuchi S, Itoh T, et al. In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors[J]. Toxicology, 2013, 314(1): 76-83
冯帆, 张帆, 司文, 等. 孕烷X受体应答元件萤光素酶报告基因的构建及活性检测[J]. 解放军医学院学报, 2015, 36(2): 166-170 Feng F, Zhang F, Si W, et al. Construction of pregnane X receptor response elements (ER6 and DR3) luciferase reporter and its transcription activity[J]. Academic Journal of Chinese PLA Medical School, 2015, 36(2): 166-170(in Chinese)
Finlay D B, Duffull S B, Glass M. 100 years of modelling ligand-receptor binding and response: A focus on GPCRs[J]. British Journal of Pharmacology, 2020, 177(7): 1472-1484
Nilles J, Weiss J, Haefeli W E, et al. How to avoid misinterpretation of dual reporter gene assay data affected by cell damage[J]. Archives of Toxicology, 2022, 96(9): 2501-2510
Creusot N, Gassiot M, Alaterre E, et al. The anti-cancer drug dabrafenib is a potent activator of the human pregnane X receptor[J]. Cells, 2020, 9(7): 1641
Nasser V M, Mahmoud R J. Differential toxicity of rifampcin on HepG2 and Hep2 cells using MTT test and electron microscope[J]. Pharmacologyonline, 2007, 3: 405-413
Svecova L, Vrzal R, Burysek L, et al. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression[J]. Drug Metabolism and Disposition: The Biological Fate of Chemicals, 2008, 36(2): 339-348
Xue Y, Moore L B, Orans J, et al. Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition[J]. Molecular Endocrinology, 2007, 21(5): 1028-1038
Creusot N, Garoche C, Grimaldi M, et al. A comparative study of human and zebrafish pregnane X receptor activities of pesticides and steroids using in vitro reporter gene assays[J]. Frontiers in Endocrinology, 2021, 12: 665521
Toporova L, Grimaldi M, Boulahtouf A, et al. Assessing the selectivity of FXR, LXRs, CAR, and RORγ pharmaceutical ligands with reporter cell lines[J]. Frontiers in Pharmacology, 2020, 11: 1122
Das B C, Madhukumar A V, Anguiano J, et al. Synthesis of novel ketoconazole derivatives as inhibitors of the human pregnane X receptor (PXR; NR1I2; also termed SXR, PAR)[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18(14): 3974-3977
Neale P A, Leusch F D L. Considerations when assessing antagonism in vitro: Why standardizing the agonist concentration matters[J]. Chemosphere, 2015, 135: 20-23
Li C H, Shi Y L, Li M J, et al. Receptor-bound perfluoroalkyl carboxylic acids dictate their activity on human and mouse peroxisome proliferator-activated receptor γ[J]. Environmental Science & Technology, 2020, 54(15): 9529-9536
Watkins R E, Wisely G B, Moore L B, et al. The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity[J]. Science, 2001, 292(5525): 2329-2333
Kliewer S A, Goodwin B, Willson T M. The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism[J]. Endocrine Reviews, 2002, 23(5): 687-702
Zhang L Y, Ren X M, Wan B, et al. Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ[J]. Toxicology and Applied Pharmacology, 2014, 279(3): 275-283
Wong F, Suzuki G, Michinaka C, et al. Dioxin-like activities, halogenated flame retardants, organophosphate esters and chlorinated paraffins in dust from Australia, the United Kingdom, Canada, Sweden and China[J]. Chemosphere, 2017, 168: 1248-1256
Tang B, Christia C, Malarvannan G, et al. Legacy and emerging organophosphorus flame retardants and plasticizers in indoor microenvironments from Guangzhou, South China[J]. Environment International, 2020, 143: 105972
Poma G, Glynn A, Malarvannan G, et al. Dietary intake of phosphorus flame retardants (PFRs) using Swedish food market basket estimations[J]. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 2017, 100: 1-7
Xu C K, Ma H J, Gao F M, et al. Screening of organophosphate flame retardants with placentation-disrupting effects in human trophoblast organoid model and characterization of adverse pregnancy outcomes in mice[J]. Environmental Health Perspectives, 2022, 130(5): 57002
Li Y, Kang Q Y, Chen R C, et al. 2-ethylhexyl diphenyl phosphate and its hydroxylated metabolites are anti-androgenic and cause adverse reproductive outcomes in male Japanese medaka (Oryzias latipes)[J]. Environmental Science & Technology, 2020, 54(14): 8919-8925
Hu W X, Gao F M, Zhang H, et al. Activation of peroxisome proliferator-activated receptor gamma and disruption of progesterone synthesis of 2-ethylhexyl diphenyl phosphate in human placental choriocarcinoma cells: Comparison with triphenyl phosphate[J]. Environmental Science & Technology, 2017, 51(7): 4061-4068
Hu W X, Jia Y T, Kang Q Y, et al. Screening of house dust from Chinese homes for chemicals with liver X receptors binding activities and characterization of atherosclerotic activity using an in vitro macrophage cell line and ApoE-/- mice[J]. Environmental Health Perspectives, 2019, 127(11): 117003
Ya M L, Yu N Y, Zhang Y Y, et al. Biomonitoring of organophosphate triesters and diesters in human blood in Jiangsu Province, Eastern China: Occurrences, associations, and suspect screening of novel metabolites[J]. Environment International, 2019, 131: 105056
Gao J, Xie W. Targeting xenobiotic receptors PXR and CAR for metabolic diseases[J]. Trends in Pharmacological Sciences, 2012, 33(10): 552-558
Sui Y P, Helsley R N, Park S H, et al. Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia[J]. Molecular Endocrinology, 2015, 29(5): 765-776