水蚤分子生态毒理学研究进展
Advances in Ecotoxicogenomics with Water Fleas
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摘要: 水蚤是广泛分布于各类淡水水体中的浮游动物，在水生生态系统中具有重要地位，也是水生毒理学研究中常用的模式生物。近年来，分子毒理学的发展为水蚤生态毒理学研究提供了新的工具和研究思路。本文分别从基因组学、转录组学、蛋白质组学、代谢组学和表观遗传组学方面，综述了不同环境污染物(重金属、农药和杀菌剂等有机污染物、环境激素类化合物、纳米材料和藻毒素等)对水蚤的生态毒理学效应及分子机制，为通过水蚤生态毒理学研究进行环境污染生物标志物筛选及生态风险评估提供参考。Abstract: Water fleas are the keystone aquatic organisms in most fresh water habitats, which have been often adopted as the model testing organisms in ecotoxicological experiments due to the advantages of high sensitivity to toxic substances, easy cultivation and high growth rate, etc. In recent years, the development of molecular toxicology has provided new tools and concept for the study of aquatic ecotoxicology. The omics-based technologies can facilitate molecular ecotoxicology studies in water fleas, better understanding and improving the knowledge on how environmental stressors, such as heavy metals, organic compounds and nanoparticles, cause toxicity in ecologically relevant organisms. In this review, the commonly used omic technologies, including genomic (or transcriptomic), protomic, metabolomic analyses as well as epigenetic technology have been discussed in order to provide references for the application of water fleas in ecotoxicology for screening of biomarkers and ecological risk assessment.
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Key words:
- water flea /
- molecular ecotoxicology /
- ecotoxigenomics /
- biomarker
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