双酚A替代品与双酚A对非洲爪蛙急性毒性及其应激响应的比较
Comparison on Acute Toxicity and Stress Induction of Bisphenol A with Its Substitutes to Xenopus laevis
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摘要: 双酚F(bisphenol F, BPF)和双酚AF(bisphenol AF, BPAF)作为双酚A(bisphenol A, BPA)的替代品已被投入生产和使用，然而目前有关BPA替代品毒性的数据还很缺乏。本文从急性毒性和应激响应2个方面比较了BPF、BPAF与BPA对非洲爪蛙蝌蚪的毒性。结果表明，48 h的半致死浓度(LC50)顺序为BPF(11.01 mg L-1)＞BPA(7.54 mg L-1)＞BPAF(2.87 mg L-1)；对氧化应激水平的影响BPAF强于BPA，BPF与BPA相近；BPA和BPAF对热休克蛋白基因表达水平有影响，BPF没有影响。本研究提示，BPAF作为BPA的替代品，其毒性强于BPA，而BPF与BPA类似。Abstract: Bisphenol F (BPF) and bisphenol AF (BPAF) have been used as bisphenol A (BPA) substitutes, but little is known about their toxic effects. In this study, we compared acute toxicity and stress induction between BPF/BPAF and BPA in Xenopus laevis tadpoles. It is found that 48 h-LC50 values of BPA and its substitutes were BPF (11.01 mg L-1) > BPA (7.54 mg L-1) > BPAF (2.87 mg L-1). The oxidative stress induction of BPAF on X. laevis tadpoles was stronger than that of BPA and BPF. In addition, BPA has more remarkable effects on the expression of heat shock protein gene than BPF, and BPAF has little ffects. Our study indicates that BPA is less harmful than BPAF, and is close to BPA.
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Key words:
- bisphenol A /
- bisphenol F /
- bisphenol AF /
- Xenopus laevis /
- acute toxicity /
- oxidative stress /
- heat shock protein
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