雌激素干扰物的联合毒性研究进展
Recent Research Advances in Joint Toxicity of Estrogenic Disruptors
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摘要: 生物体对雌激素高度敏感，环境中的雌激素干扰物可以在低浓度下干扰内源雌激素的正常功能，导致雌激素干扰物在数十年间都是环境科学的研究热点之一。所有生物均暴露在复杂的环境污染物中，多种干扰物共同存在产生的混合物效应更应受到关注。为预测和评价环境雌激素干扰物的联合效应，许多研究从数学模型、信号通路分析等方面提出了解决方法并加以应用，本文综述了雌激素污染物混合作用联合毒性研究模型的发展和现存问题，进而对未来的发展进行了展望。Abstract: Organisms are highly sensitive to estrogens. Due to their ability of interfering with normal function of endogenous estrogen at very low concentration, they have been a research hotspot of environmental science for decades. Different from the toxicity test conducted under strictly controlled conditions, in reality all organisms are exposed to complex environmental pollutants, leading to particular concern on the mixture effects produced by the co-existence of estrogenic disruptors. In order to predict and evaluate the joint action of environmental estrogenic disruptors, mathematical models and signal pathway analysis have been developed and applied. This paper summarizes the traditional and recent prediction methods in this field, and discusses the future research directions for combined toxicity of estrogenic disruptors.
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Key words:
- estrogen disruptors /
- mixture /
- combined effects /
- additive model /
- mode of action
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Petrovic M, Eljarrat E, Lopez de Alda M J, et al. Endocrine disrupting compounds and other emerging contaminants in the environment:A survey on new monitoring strategies and occurrence data[J]. Analytical and Bioanalytical Chemistry, 2004, 378(3):549-562 Hotchkiss A K, Rider C V, Blystone C R, et al. Fifteen years after "wingspread"-Environmental endocrine disrupters and human and wildlife health:Where we are today and where we need to go[J]. Toxicological Sciences, 2008, 105(2):235-259 Vandenberg L N, Colborn T, Hayes T B, et al. Hormones and endocrine-disrupting chemicals:Low-dose effects and nonmonotonic dose responses[J]. Endocrine Reviews, 2012, 33(3):378-455 Zha J M, Wang Z J, Wang N, et al. Histological alternation and vitellogenin induction in adult rare minnow (Gobiocypris rarus) after exposure to ethynylestradiol and nonylphenol[J]. Chemosphere, 2007, 66(3):488-495 Kojima H, Takeuchi S, Nagai T. Endocrine-disrupting potential of pesticides via nuclear receptors and aryl hydrocarbon receptor[J]. Journal of Health Science, 2010, 56(4):374-386 Mnif W, Hassine A I H, Bouaziz A, et al. Effect of endocrine disruptor pesticides:A review[J]. International Journal of Environmental Research and Public Health, 2011, 8(6):2265-2303 Okada H, Tokunaga T, Liu X, et al. Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-γ[J]. Environmental Health Perspectives, 2008, 116(1):32-38 Vom Saal F S, Myers J. Bisphenol A and risk of metabolic disorders[J]. The Journal of the American Medical Association, 2008, 300(11):1353-1355 McGovern V. PCBs are endocrine disruptors:Mixture affects reproductive development in female mice[J]. Environmental Health Perspectives, 2006, 114(6):A368-A369 Peng X, Wang Z, Yang C, et al. Simultaneous determination of endocrine-disrupting phenols and steroid estrogens in sediment by gas chromatography-mass spectrometry[J]. Journal of Chromatography A, 2006, 1116(1-2):51-56 Payne J, Rajapakse N, Wilkins M, et al. Prediction and assessment of the effects of mixtures of four xenoestrogens[J]. Environmental Health Perspectives, 2000, 108(10):983-987 Silva E, Rajapakse N, Kortenkamp A. Something from "nothing"-Eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects[J]. Environmental Science and Technology, 2002, 36(8):1751-1756 Yang R, Li N, Ma M, et al. Combined effects of estrogenic chemicals with the same mode of action using an estrogen receptor binding bioassay[J]. Environmental Toxicology and Pharmacology, 2014, 38(3):829-837 Payne J, Scholze M, Kortenkamp A. Mixtures of four organochlorines enhance human breast cancer cell proliferation[J]. Environmental Health Perspectives, 2001, 109(4):391-397 Suzuki T, Ide K, Ishida M. Response of MCF-7 human breast cancer cells to some binary mixtures of oestrogenic compounds in-vitro[J]. Journal of Pharmacy and Pharmacology, 2001, 53(11):1549-1554 Rajapakse N, Silva E, Scholze M, et al. Deviation from additivity with estrogenic mixtures containing 4-nonylphenol and 4-tert-octylphenol detected in the E-SCREEN assay[J]. Environmental Science and Technology, 2004, 38(23):6343-6352 Silva E, Rajapakse N, Scholze M, et al. Joint effects of heterogeneous estrogenic chemicals in the E-Screen-exploring the applicability of concentration addition[J]. Toxicological Sciences, 2011, 122(2):383-394 Thorpe K L, Gross-Sorokin M, Johnson I, et al. An assessment of the model of concentration addition for predicting the estrogenic activity of chemical mixtures in wastewater treatment works effluents[J]. Environmental Health Perspectives, 2005, 114(S1):90-97 Sun L W, Zha J M, Wang Z J. Interactions between estrogenic chemicals in binary mixtures investigated using vitellogenin induction and factorial analysis[J]. Chemosphere, 2009, 75(3):410-415 Ribeiro C, Urbatzka R, Castro L F C, et al. In vitro exposure of Nile tilapia (Oreochromis niloticus) testis to estrogenic endocrine disrupting chemicals:mRNA expression of genes encoding steroidogenic enzymes[J]. Toxicology Mechanisms and Methods, 2012, 22(1):47-53 Arnold S F, Bergeron J M, Tran D Q, et al. Synergistic responses of steroidal estrogens in vitro (yeast) and in vivo (turtles)[J]. Biochemical and Biophysical Research Communications, 1997, 235(2):336-342 Ramamoorthy K, Vyhlidal C, Wang F, et al. Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol[J]. Toxicology and Applied Pharmacology, 1997, 147(1):93-100 Tinwell H, Ashby J. Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens[J]. Environmental Health Perspectives, 2004, 112(5):575-582 Yuan S W, Huang C, Ji X Y, et al. Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression[J]. Ecotoxicology and Environmental Safety, 2018, 160:1-9 杨蓉, 李娜, 饶凯锋, 等. 环境混合物的联合毒性研究方法[J]. 生态毒理学报, 2016, 11(1):1-13 Yang R, Li N, Rao K F, et al. Review on methodology for environmental mixture toxicity study[J]. Asian Journal of Ecotoxicology, 2016, 11(1):1-13(in Chinese)
Loewe S. Die quantitativen probleme der pharmarkologic[J]. Ergebnisse der Physiologie, 1928, 27:47-187 Van den Berg M, Birnbaum L, Bosveld A T C, et al. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife[J]. Environmental Health Perspectives, 1998, 106(12):775-792 Howard G J, Schlezinger J J, Hahn M E, et al. Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists[J]. Environmental Health Perspectives, 2010, 118(5):666-672 Brinkmann M, Hecker M, Giesy J P, et al. Generalized concentration addition accurately predicts estrogenic potentials of mixtures and environmental samples containing partial agonists[J]. Toxicology in Vitro, 2018, 46:294-303 Ezechiáš M, Cajthaml T. Novel full logistic model for estimation of the estrogenic activity of chemical mixtures[J]. Toxicology, 2016, 359-360:58-70 Ezechiáš M, Cajthaml T. Receptor partial agonism and method to express receptor partial activation with respect to novel full logistic model of mixture toxicology[J]. Toxicology, 2018, 393:26-33 Schlotz N, Kim G J, Jäger S, et al. In vitro observations and in silico predictions of xenoestrogen mixture effects in T47D-based receptor transactivation and proliferation assays[J]. Toxicology in Vitro, 2017, 45:146-157 Tapiero H, Nguyen Ba G, Tew K D. Estrogens and environmental estrogens[J]. Biomedicine and Pharmacotherapy, 2002, 56(1):36-44 Wikipedia. Receptor antagonist. (2015-4-28). http://en.wikipedia.org/wiki/Receptor_antagonist Min J, Lee S K, Gu M B. Effects of endocrine disrupting chemicals on distinct expression patterns of estrogen receptor, cytochrome P450 aromatase and p53 genes in Oryzias latipes liver[J]. Journal of Biochemical and Molecular Toxicology, 2003, 17(5):272-277 Frye C, Bo E, Calamandrei G, et al. Endocrine disrupters:A review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems[J]. Journal of Neuroendocrinology, 2012, 24(1):144-159 Kortenkamp A. Ten years of mixing cocktails:A review of combination effects of endocrine-disrupting chemicals[J]. Environmental Health Perspectives, 2007, 115:98-105 向霄, 王鲁梅, 钟铃盈, 等. 环境激素o,p'-DDT和抗雌激素氟维斯群对斑马鱼胚胎的复合效应[J]. 生态毒理学报, 2012, 7(3):251-258 Xiang X, Wang L M, Zhong L Y, et al. Combined effects of environmental estrogen o,p'-DDT and antiestrogen fulvestrant on zebrafish (Danio rerio) embryos[J]. Asian Journal of Ecotoxicology, 2012, 7(3):251-258(in Chinese)
Sun L W, Shao X, Hu X, et al. Transcriptional responses in Japanese medaka (Oryzias latipes) exposed to binary mixtures of an estrogen and anti-estrogens[J]. Aquatic Toxicology, 2011, 105(3):629-639 Sun L W, Zha J M, Wang Z J. Effects of binary mixtures of estrogen and antiestrogens on Japanese medaka (Oryzias latipes)[J]. Aquatic Toxicology, 2009, 93(1):83-89 Yang R, Li N, Rao K F, et al. Combined action of estrogen receptor agonists and antagonists in two-hybrid recombinant yeast in vitro[J]. Ecotoxicology and Environmental Safety, 2015, 111:228-235 季晓亚, 李娜, 袁圣武, 等. 环境雌激素生物效应的作用机制研究进展[J]. 生态毒理学报, 2017, 12(1):38-51 Ji X Y, Li N, Yuan S W, et al. Research progress in the mechanisms for biological effects of environmental estrogens[J]. Asian Journal of Ecotoxicology, 2017, 12(1):38-51(in Chinese)
Okubo T, Yokoyama Y, Kano K, et al. ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERα and PR[J]. Food and Chemical Toxicology, 2001, 39(12):1225-1232 Okubo T, Yokoyama Y, Kano K, et al. Estimation of estrogenic and antiestrogenic activities of selected pesticides by MCF-7 cell proliferation assay[J]. Archives of Environmental Contamination and Toxicology, 2004, 46(4):445-453 Bicchi C, Schilirò T, Pignata C, et al. Analysis of environmental endocrine disrupting chemicals using the E-screen method and stir bar sorptive extraction in wastewater treatment plant effluents[J]. Science of the Total Environment, 2009, 407(6):1842-1851 Körner W, Bolz U, Süßmuth W, et al. Input/output balance of estrogenic active compounds in a major municipal sewage plant in Germany[J]. Chemosphere, 2000, 40(9-11):1131-1142 O'Lone R, Frith M C, Karlsson E K, et al. Genomic targets of nuclear estrogen receptors[J]. Molecular Endocrinology, 2014, 18(8):1859-1875 Rangasamy V, Mishra R, Mehrotra S, et al. Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells[J]. Cancer Research, 2010, 70(4):1731-1740 Bjornstrom L, Sjoberg M. Mechanisms of estrogen receptor signaling:Convergence of genomic and nongenomic actions on target genes[J]. Molecular and Cellular Endocrinology, 2005, 19(4):833-842 Bopp S K, Kienzler A, Richarz A N, et al. Regulatory assessment and risk management of chemical mixtures:Challenges and ways forward[J]. Critical Reviews in Toxicology, 2019, 49(2):174-189 Bopp S K, Berggren E, Kienzler A, et al. Scientific methodologies for the assessment of combined effects of chemicals-A survey and literature review[R]. Luxembourg:European Union, 2015 Punt A, Brand W, Murk A J, et al. Effect of combining in vitro estrogenicity data with kinetic characteristics of estrogenic compounds on the in vivo predictive value[J]. Toxicology in Vitro, 2013, 27(1):44-51 -
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