代谢组学在化学品风险评价中的应用
Application of Metabolomics in Chemical Risk Assessment
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摘要: 随着化学品的数量日益增长，其潜在毒性对人类及环境中的非靶标生物造成了严重威胁。化学品风险评估的速度已经跟不上化学品的发展速度，急需根据现代毒理学技术的发展，对化学品风险评估方法进行丰富与发展。代谢组学作为系统生物学最下游的组学技术，是整体性研究生命体系功能变化的重要学科之一。基于代谢组学的毒理学评价方法不仅具有成本低、周期短和实验动物消耗少等特点，而且可以快速筛选出低剂量化学品早期暴露的生物标记物，揭示化学品毒性作用通路及机制。本文主要介绍了代谢组学的起源与发展、代谢组学技术应用于毒理学评价的优势、案例及前景展望。Abstract: With the increasing amount of chemicals, the potential toxicity poses a serious threat to humans and non-target organisms in environment. As the speed of chemical risk assessment has not kept pace with the development of chemicals, it is urgent to enrich and develop the chemical risk assessment methods according to the modern toxicology technology. Metabolomics, as the downstream omics technology of system biology, is one of the important subjects to study the function changes of life system integrality. The toxicological evaluation method based on metabolomics is not only characterized by the low cost, short experiment cycle and low consumption of experimental animals, but also stand out from the quickly biomarker screening of early low dose chemical exposure and unraveling the pathway and mechanism of chemical toxicity. This paper mainly introduced the origin and development of metabolomics, the advantages, cases and prospects of the application of metabolomics in toxicological evaluation.
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Key words:
- metabolomics /
- nuclear magnetic resonance (NMR) /
- mass spectra /
- toxicology /
- toxic mechanism
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