双酚类化合物污染现状及对生命早期的不良影响
Pollution Status and Adverse Effects of Bisphenols on Early Life
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摘要: 双酚类化合物广泛应用于日用品生产。本研究首先综述双酚类化合物的污染现状，发现其在多个国家的室内灰尘、地表水、饮用水处理厂水源、污水处理厂污泥和沉积物等环境介质、食物尤其是罐装食品和饮料甚至尿液、血液、胎盘、母乳、羊水、脑组织、头发和脂肪等人体样本中均有检出，主要为双酚A、双酚S、双酚F和双酚AF。相比成年人，胎儿和儿童接触更多的双酚类化合物，且对暴露更为敏感。本文从生殖毒性、神经毒性、呼吸和免疫毒性、致肥胖效应和发育毒性等方面综述生命早期接触双酚类化合物产生的不良影响，发现双酚S、双酚F等双酚A替代物具有与双酚A相似的毒性效应。最后，从检测方法标准化、加强环境流行病学研究等方面对今后的研究进行了展望。Abstract: Bisphenols are extensively used in the products of daily necessities. In the present study, firstly, we summarized the pollution status of bisphenols, and found that, bisphenols including bisphenol A, bisphenol S, bisphenol F, and bisphenol AF were detected in indoor dust, surface water, source water of drinking water treatment plant, sludge of sewage treatment plant, sediment, food especially canned food and beverages, even in human samples such as urine, blood, placenta, breast milk, amniotic fluid, brain tissue, hair and adipose tissue in many countries. Compared with adults, fetuses and children are exposed to more bisphenols and more sensitive to bisphenols. We also investigated the adverse effects of early life exposure to bisphenols, including toxicities to reproductive, nervous, respiratory, immune, developmental system and obesogenic effects. Our study showed that toxicities of bisphenol A analogues such as bisphenol S and bisphenol F were similar to that of bisphenol A. Further, we provided the prospect on future researches in terms of standardization of detection methods and development of environmental epidemiology.
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Key words:
- bisphenols /
- pollution status /
- early life /
- adverse effects
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