金属污染物对神经系统损害及毒性机制研究进展

范洁琳; 徐丽伟; 王慧; 江汉臣; 熊鲲

生态毒理学报

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范洁琳, 徐丽伟, 王慧, 江汉臣, 熊鲲. 金属污染物对神经系统损害及毒性机制研究进展[J]. 生态毒理学报, 2012, 7(3): 234-240.

引用本文:

范洁琳, 徐丽伟, 王慧, 江汉臣, 熊鲲. 金属污染物对神经系统损害及毒性机制研究进展[J]. 生态毒理学报, 2012, 7(3): 234-240.

Fan Jielin, Xu Liwei, Wang Hui, Jiang Hanchen, Xiong Kun. Research Advances in Toxicity of Metal Pollutants to Nervous System and Its Mechanism[J]. Asian journal of ecotoxicology, 2012, 7(3): 234-240.

Citation:

Fan Jielin, Xu Liwei, Wang Hui, Jiang Hanchen, Xiong Kun. Research Advances in Toxicity of Metal Pollutants to Nervous System and Its Mechanism[J]. Asian journal of ecotoxicology, 2012, 7(3): 234-240.

金属污染物对神经系统损害及毒性机制研究进展

1. 中南大学湘雅医学院临床医学系, 长沙 410013;
2. 中南大学基础医学院人体解剖学与神经生物学系, 长沙 410013;
3. 长沙医学院解剖教研室, 长沙 410219

作者简介: 范洁琳(1987-),女,博士,研究方向为神经遗传学,E-mail:fun-633@qq.com;徐丽伟(1986-),女,博士,研究方向为神经遗传学,E-mail:iat2204060224@163.com

基金项目:
国家自然科学基金(30900773)

湖南省自然科学基金(11JJ2020)

教育部属高校科研业务费重点项目(2010QZZD022)
中图分类号: X171.5;R994.6

Research Advances in Toxicity of Metal Pollutants to Nervous System and Its Mechanism

1. Department of Clinical Medicine, XiangYa School of Medicine, Central South University, Changsha 410013, China;
2. Department of Anatomy and Neurobiology, School of Basic Medicine, Central South University, Changsha 410013, China;
3. Department of Anatomy, Changsha Medical College, Changsha 410219, China
Fund Project:

摘要: 神经系统与生物体其他系统联系密切,共同维持机体正常的结构和功能。环境中的金属污染物可通过多种途径进入生物体,干扰幼年或成年动物神经系统的发育和功能,其损害机制是目前研究的热点。本文系统地总结了汞、铅和铝等金属污染物对神经系统的损害作用,着重在细胞、分子和基因水平上阐述了金属对神经系统的毒性机制,在此基础上分析了当前研究的不足之处和发展趋势,并对今后的研究方向进行了展望。
- 神经系统 /
- 毒性机制 /
- 金属污染物
Abstract: Nervous system is closely linked with other systems in organisms, coordinately maintaining the normal structure and function of organisms. Metal pollutants can enter the organisms by various routes and interfere with the development and function of nervous system in juveniles and adults. The mechanism of metal neurotoxicity is becoming a hot topic in this field. In this paper, the neurotoxicity of several common metal pollutants including mercury, lead and aluminum was systematically summarized, and the toxicity mechanisms were elaborated especially at the cellular, molecular and genetic levels. On these bases, the existing problems and further research directions were pointed out to provide a roadmap for future study in this field.
- nervous system /
- toxicity mechanism /
- metal pollutant

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范洁琳, 徐丽伟, 王慧, 江汉臣, 熊鲲. 金属污染物对神经系统损害及毒性机制研究进展[J]. 生态毒理学报, 2012, 7(3): 234-240.

引用本文:

范洁琳, 徐丽伟, 王慧, 江汉臣, 熊鲲. 金属污染物对神经系统损害及毒性机制研究进展[J]. 生态毒理学报, 2012, 7(3): 234-240.

Citation:

金属污染物对神经系统损害及毒性机制研究进展

作者简介: 范洁琳(1987-),女,博士,研究方向为神经遗传学,E-mail:fun-633@qq.com;徐丽伟(1986-),女,博士,研究方向为神经遗传学,E-mail:iat2204060224@163.com
1. 中南大学湘雅医学院临床医学系, 长沙 410013;

2. 中南大学基础医学院人体解剖学与神经生物学系, 长沙 410013;

3. 长沙医学院解剖教研室, 长沙 410219

收稿日期: 2010-09-11

基金项目:

国家自然科学基金(30900773)

湖南省自然科学基金(11JJ2020)

教育部属高校科研业务费重点项目(2010QZZD022)

关键词:

摘要: 神经系统与生物体其他系统联系密切,共同维持机体正常的结构和功能。环境中的金属污染物可通过多种途径进入生物体,干扰幼年或成年动物神经系统的发育和功能,其损害机制是目前研究的热点。本文系统地总结了汞、铅和铝等金属污染物对神经系统的损害作用,着重在细胞、分子和基因水平上阐述了金属对神经系统的毒性机制,在此基础上分析了当前研究的不足之处和发展趋势,并对今后的研究方向进行了展望。

English Abstract

Research Advances in Toxicity of Metal Pollutants to Nervous System and Its Mechanism

1. Department of Clinical Medicine, XiangYa School of Medicine, Central South University, Changsha 410013, China;
2. Department of Anatomy and Neurobiology, School of Basic Medicine, Central South University, Changsha 410013, China;
3. Department of Anatomy, Changsha Medical College, Changsha 410219, China

Received Date: 2010-09-11

Fund Project:

Keywords:

Abstract: Nervous system is closely linked with other systems in organisms, coordinately maintaining the normal structure and function of organisms. Metal pollutants can enter the organisms by various routes and interfere with the development and function of nervous system in juveniles and adults. The mechanism of metal neurotoxicity is becoming a hot topic in this field. In this paper, the neurotoxicity of several common metal pollutants including mercury, lead and aluminum was systematically summarized, and the toxicity mechanisms were elaborated especially at the cellular, molecular and genetic levels. On these bases, the existing problems and further research directions were pointed out to provide a roadmap for future study in this field.

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金属污染物对神经系统损害及毒性机制研究进展

作者简介: 范洁琳(1987-),女,博士,研究方向为神经遗传学,E-mail:fun-633@qq.com;徐丽伟(1986-),女,博士,研究方向为神经遗传学,E-mail:iat2204060224@163.com

Research Advances in Toxicity of Metal Pollutants to Nervous System and Its Mechanism

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金属污染物对神经系统损害及毒性机制研究进展

English Abstract

Research Advances in Toxicity of Metal Pollutants to Nervous System and Its Mechanism

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