摘要:
三氯生(triclosan)是一种广泛使用的抗菌剂和杀菌剂,主要添加于个人护理品等各类消费产品中。目前,三氯生在各种环境介质和生物体中普遍存在,其具有亲脂性、持久性、生物累积性和毒性,对生态环境和人类健康造成了潜在危害。归纳和分析了近年来国内外有关三氯生的研究成果,全面系统地介绍了三氯生在环境中的分布现状、生态效应和生物降解等,重点讨论了三氯生的环境毒性,以及三氯生杀菌的作用机制及其导致的细菌耐药性,最后对未来的研究工作进行了展望。
Abstract:
Triclosan, an antimicrobial agent and bactericide, has been incorporated into a broad array of personal care products and consumer products. Studies showed that triclosan, which was found in different types of environmental matrix and in biological samples, was highly lipophilic, persistent, bioaccumulative and toxic. Great concerns were raised about the potential hazard of triclosan to the environment and human health. Based on the summaries of the current world-wide researches on triclosan, this paper reviewed the current occurrence and distribution, ecotoxicological effects and biodegradation of triclosan in the environment, and particularly focused on the environmental toxicity and mechanism of antimicrobial action of triclosan, and the antimicrobial resistance induced by triclosan. Finally, the future research directions were prospected.
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