双酚类化合物污染现状和内分泌干扰效应研究进展
Advances on Pollution Status and Endocrine Disrupting Effects of Bisphenols
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摘要: 双酚类化合物(bisphenols,BPs)是合成碳酸聚酯、环氧树脂和聚丙烯酸酯等高分子聚合物的主要原料，在商业制造中广泛使用。经过度排放污染环境，并能通过食物链放大作用在动物和人体内蓄积。已经在水体、底泥、室内灰尘、食品以及动物和人体内检测到双酚A (bisphenol A,BPA)及其替代品或衍生物等多种BPs。BPs对性激素、甲状腺素和神经内分泌系统具有干扰效应，能影响机体生殖功能、性腺发育、神经行为和激素依赖性疾病的发展，已经成为危害人体健康的风险因子。多种BPA替代品的内分泌干扰效应甚至比BPA更强，但缺乏全面的内分泌干扰效应评估数据和对作用机制的深入研究。本文对BPs种类来源、污染现状及其内分泌干扰效应进行综述。Abstract: Bisphenols (BPs) are widely used as the primary raw materials for synthesizing polyester carbonate, epoxy resin, and polyacrylate to manufacture high molecular polymers. After being excessively discharged, BPs pollute the environment and accumulate in animals and humans bodies via the biomagnification of the food chain. So far, various BPs have been detected in water, sediment, indoor dust, food, as well as the animal and human body, including bisphenol A (BPA) and its multiple substitutes and derivatives. It has been reported that BPs interfere with gonadal hormone endocrine, thyroxine endocrine, and neuroendocrine, which can further affect reproductive function, gonadal development, neurobehavior, and hormone-dependent diseases. Therefore, BPs have become risk factors that endanger human health. The endocrine-disrupting effects of BPA substitutes are even more potent than that of BPA, and comprehensive endocrine-disrupting effects and underlying mechanisms require to be further studied. Here we summarize the state of the current knowledge about the sources, pollution status, and endocrine-disrupting effects of BPs.
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Key words:
- bisphenols /
- pollution status /
- endocrine-disrupting effects
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