增塑剂DEHP神经毒性作用及机制的研究进展
Research Progress on Neurotoxic Effects and Mechanism of Plasticizer DEHP
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摘要: 近年来，增塑剂邻苯二甲酸二(2-乙基己)酯(di-(2-ethylhexyl) phthalate, DEHP)的神经毒性作用越来越受到人们的关注。DEHP可通过多种途径进入脑组织并作用于中枢神经系统，导致各种损伤。因此，笔者系统阐述DEHP进入脑组织的途径、神经毒性作用表现及其机制，为今后深入研究DEHP的健康效应及分子机制，制定更为合理的、针对不同暴露人群的安全限值和暴露限值提供理论参考。
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关键词:
- 邻苯二甲酸二(2-乙基己)酯 /
- 神经毒性 /
- 阿尔茨海默症
Abstract: In recent years, the neurotoxicity of the plasticizer di-(2-ethylhexyl) phthalate (DEHP) has attracted more and more attention. DEHP can enter the brain tissue through a variety of routes and act on the central nervous system, causing various injuries. Therefore, this review systematically elucidates the ways that DEHP enters the brain tissue, its neurotoxic effects and underlying mechanisms so as to provide recommendations for future research on the health effects and molecular mechanisms of DEHP, and also to provide references to develop more reasonable safety and exposure limits for different exposed groups.-
Key words:
- bis(2-ethylhexyl) phthalate /
- neurotoxicity /
- Alzheimer’s disease
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