粮食真菌毒素的生殖、发育与遗传毒性：现状与展望
Reproductive, Developmental and Genetic Toxicities of Grain Mycotoxins: Current Status and Prospects
-
摘要: 粮食及其制品会受到多种真菌毒素的污染。粮食真菌毒素现已被证实具有多种毒性作用，如细胞毒性、发育毒性、生殖毒性、免疫毒性和遗传毒性等，严重危害人和动物健康，甚至还会对间接或未接触毒素的子代产生不良影响，但目前有关继代毒理学数据极为缺乏。本文主要阐述了粮食中常见真菌毒素对亲本世代及其子代生殖系统/能力和生长发育的影响，简述了不同毒素诱导生殖发育毒性的作用机理并提出展望，旨在全面了解粮食真菌毒素的生殖发育及遗传毒性作用，为进一步开展粮食真菌毒素的健康风险评估，合理制定相关限量标准与法规，指导公共卫生健康并开展主动防治与干预提供重要理论依据。Abstract: Grain and its products can often be contaminated by diverse mycotoxins. Mycotoxins have been proved to have a variety of toxic effects, such as cytotoxicity, developmental toxicity, reproductive toxicity, immunotoxicity, genotoxicity, etc., which can seriously harm human and animal health, and even have adverse effects on the offspring that are indirectly exposed or unexposed to mycotoxins. However, the relevant toxicology data of offspring are relatively lacking. In this review, the reproductive/developmental toxicity and genotoxicity of the mycotoxins found in grain foods on the parental and filial generations were comprehensively discussed, the relevant mechanisms were summarized and the prospects for the future study were also expounded. Our aim was to comprehensively understand the reproductive, developmental and genetic toxicities of mycotoxins in grains, and to provide important theoretical bases for further promoting health risk assessments of grain mycotoxins, scientifically establishing limit standards and regulations, correctly guiding public health, and actively developing prevention and intervention.
-
Key words:
- mycotoxin /
- reproductive toxicity /
- developmental toxicity /
- genetic toxicity /
- transgenerational toxicity /
- mechanism
-
-
Zhou H Y, George S, Li C X, et al. Combined toxicity of prevalent mycotoxins studied in fish cell line and zebrafish larvae revealed that type of interactions is dose-dependent[J]. Aquatic Toxicology, 2017, 193:60-71 Luo S J, Du H L, Kebede H, et al. Contamination status of major mycotoxins in agricultural product and food stuff in Europe[J]. Food Control, 2021, 127:108120 Koletsi P, Schrama J W, Graat E A M, et al. The occurrence of mycotoxins in raw materials and fish feeds in Europe and the potential effects of deoxynivalenol (DON) on the health and growth of farmed fish species:A review[J]. Toxins, 2021, 13(6):403 Jin J, Beekmann K, Ringø E, et al. Interaction between food-borne mycotoxins and gut microbiota:A review[J]. Food Control, 2021, 126:107998 Biomin. World mycotoxin survey 2019[EB/OL].[2021-07-20]. https://www.biomin.net/downloads/2019-biomin-world-mycotoxin-survey-report/ 韩小敏,李凤琴,徐文静.食品中白僵菌素和恩镰孢菌素的污染情况及分析方法研究进展[J].中国食品卫生杂志, 2017, 29(4):508-513 Han X M, Li F Q, Xu W J. Research progress on the contamination of beauvericin and enniatins and the development of analytical method in food[J]. Chinese Journal of Food Hygiene, 2017, 29(4):508-513(in Chinese)
Supriya C, Girish B P, Reddy P S. Aflatoxin B1-induced reproductive toxicity in male rats:Possible mechanism of action[J]. International Journal of Toxicology, 2014, 33(3):155-161 Kovács M, Tornyos G, Matics Z, et al. Effect of chronic T-2 toxin exposure in rabbit bucks, determination of the No Observed Adverse Effect Level (NOAEL)[J]. Animal Reproduction Science, 2013, 137(3-4):245-252 周鸿媛,唐莉莉,路勇,等.脱氧雪腐镰刀菌烯醇、黄曲霉毒素B1和玉米赤霉烯酮对秀丽隐杆线虫的联合毒性研究[J].生态毒理学报, 2018, 13(3):112-121 Zhou H Y, Tang L L, Lu Y, et al. Study on the combinatorial toxicity of deoxynivalenol, aflatoxin B1 and zearalenone on Caenorhabditis elegans [J]. Asian Journal of Ecotoxicology, 2018, 13(3):112-121(in Chinese)
陈铃霞. ZEN与DON对雄性小鼠生殖系统的联合毒性及茶多酚的保护作用研究[D].合肥:安徽农业大学, 2019:34-39Chen L X. Combined toxicity of ZEN and DON to the reproductive system of male mice and the protective effect of tea polyphenols[D]. Hefei:Anhui Agricultural University, 2019:34 -39(in Chinese)
周鸿媛.脱氧雪腐镰刀菌烯醇(DON)的多代毒性及其联合毒性研究[D].无锡:江南大学, 2018:38-54Zhou H Y. Study on the multi-generational and combined toxic effects of deoxynivalenol (DON)[D]. Wuxi:Jiangnan University, 2018:38 -54(in Chinese)
Dalla Bona M, Lizzi F, Borgato A, et al. Increasing toxicity of enrofloxacin over four generations of Daphnia magna [J]. Ecotoxicology and Environmental Safety, 2016, 132:397-402 Shaw J L A, Judy J D, Kumar A, et al. Incorporating transgenerational epigenetic inheritance into ecological risk assessment frameworks[J]. Environmental Science&Technology, 2017, 51(17):9433-9445 Owumi S E, Adedara I A, Akomolafe A P, et al. Gallic acid enhances reproductive function by modulating oxido-inflammatory and apoptosis mediators in rats exposed to aflatoxin-B1[J]. Experimental Biology and Medicine, 2020, 245(12):1016-1028 Gao X, Sun L H, Zhang N Y, et al. Gestational zearalenone exposure causes reproductive and developmental toxicity in pregnant rats and female offspring[J]. Toxins, 2017, 9(1):E21 Shen J K, Perveen A, Kaka N, et al. Maternal exposure to T-2 toxin induces changes in antioxidant system and testosterone synthesis in the testes of mice offspring[J]. Animals:An Open Access Journal from MDPI, 2019, 10(1):E74 李雨哲.玉米赤霉烯酮对生殖靶器官细胞毒性机制研究[D].北京:中国农业大学, 2014:12-68Li Y Z. Investigation of the mechanism of the reproductive toxicity of zearalenone on cells from target organ[D]. Beijing:China Agriculture University, 2014:12 -68(in Chinese)
李洪蛟.丙酸睾酮对小鼠睾丸BNNF、NGF、NT-3和NT-4神经营养素表达的影响[D].长春:吉林大学, 2016:28-34Li H J. Effects of testosterone propionate on the expression of BDNF, NGF, NT-3 and NT-4 neurotrophins in testes of mice[D]. Changchun:Jilin University, 2016:28-34(in Chinese)
Zhou H Y, Wang J M, Ma L, et al. Oxidative DNA damage and multi-organ pathologies in male mice subchronically treated with aflatoxin B1[J]. Ecotoxicology and Environmental Safety, 2019, 186:109697 Yang J H, Wang J H, Guo W B, et al. Toxic effects and possible mechanisms of deoxynivalenol exposure on sperm and testicular damage in BALB/c mice[J]. Journal of Agricultural and Food Chemistry, 2019, 67(8):2289-2295 Pang J, Zhou Q S, Sun X F, et al. Effect of low-dose zearalenone exposure on reproductive capacity of male mice[J]. Toxicology and Applied Pharmacology, 2017, 333:60-67 Eze U A, Huntriss J D, Routledge M N, et al. In vitro effects of single and binary mixtures of regulated mycotoxins and persistent organochloride pesticides on steroid hormone production in MA-10 Leydig cell line[J]. Toxicology in Vitro, 2019, 60:272-280 张新宇.睾丸生殖功能调控的初步研究[D].北京:北京协和医学院, 2013:43-46 Khoury D E, Fayjaloun S, Nassar M, et al. Updates on the effect of mycotoxins on male reproductive efficiency in mammals[J]. Toxins, 2019, 11(9):515 Men Y H, Zhao Y, Zhang P F, et al. Gestational exposure to low-dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications[J]. Basic&Clinical Pharmacology&Toxicology, 2019, 125(4):382-393 Jee Y, Noh E M, Cho E S, et al. Involvement of the Fas and Fas ligand in testicular germ cell apoptosis by zearalenone in rat[J]. Journal of Veterinary Science, 2010, 11(2):115-119 Wang B J, Zheng W L, Feng N N, et al. The effects of autophagy and PI3K/AKT/m-TOR signaling pathway on the cell-cycle arrest of rats primary Sertoli cells induced by zearalenone[J]. Toxins, 2018, 10(10):E398 Li Y Y, Huang P, Gao F Y, et al. Selenium ameliorates aflatoxin B1-induced uterine injury in female mice and necrosis of human endometrial microvascular endothelial cells[J]. Journal of Applied Toxicology, 2021, 41(5):799-810 Wang Y, Zhang J, Wang Y L, et al. Isolation and characterization of the Bacillus cereus BC7 strain, which is capable of zearalenone removal and intestinal flora modulation in mice[J]. Toxicon:Official Journal of the International Society on Toxinology, 2018, 155:9-20 Ahmad B, Shrivastava V K, Saleh R, et al. Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice ( Mus musculus )[J]. Clinical and Experimental Reproductive Medicine, 2018, 45(4):163-169 Jia H Q, Jia C Q, An Q L, et al. Ochratoxin A exposure causes meiotic failure and oocyte deterioration in mice[J]. Theriogenology, 2020, 148:236-248 Yang M, Wu X D, Zhang W, et al. Transcriptional analysis of deoxynivalenol-induced apoptosis of sow ovarian granulosa cell[J]. Reproduction in Domestic Animals, 2020, 55(2):217-228 Zhang T Y, Kong L, Hao J X, et al. Effects of ochratoxin A exposure on DNA damage in porcine granulosa cells in vitro [J]. Toxicology Letters, 2020, 330:167-175 Silva T, de Brito D C C, de Sá N A R, et al. Equol:A microbiota metabolite able to alleviate the negative effects of zearalenone during in vitro culture of ovine preantral follicles[J]. Toxins, 2019, 11(11):652 Shi D H, Zhou J C, Zhao L H, et al. Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts[J]. Journal of Animal Science and Biotechnology, 2018, 9:42 尹亚南.金乌贼生殖系统结构特征和卵子发生的研究[D].上海:上海海洋大学, 2018:10Ying Y N. Studies on structure of reproductive system and oogenesis in Sepia esculenta Hoyle[D]. Shanghai:Shanghai Ocean University, 2018:10(in Chinese) Cheng L H, Qin Y S, Hu X, et al. Melatonin protects in vitro matured porcine oocytes from toxicity of aflatoxin B1[J]. Journal of Pineal Research, 2019, 66(4):e12543 Mastrorocco A, Martino N A, Marzano G, et al. The mycotoxin beauvericin induces oocyte mitochondrial dysfunction and affects embryo development in the juvenile sheep[J]. Molecular Reproduction and Development, 2019, 86(10):1430-1443 Schoevers E J, Santos R R, Roelen B A J. Alternariol disturbs oocyte maturation and preimplantation development[J]. Mycotoxin Research, 2020, 36(1):93-101 Ye X Q, Andersen C, Zhao F. Effects of mycoestrogens on female reproduction[J]. Reproductive and Developmental Medicine, 2018, 2(1):52 胡进.玉米赤霉烯酮对小鼠子宫内膜基质细胞的毒性作用及机制研究[D].南京:南京农业大学, 2016:52-58Hu J. Toxicity of zearalenone and its mechanism on mouse endometrial stromal cells[D]. Nanjing:Nanjing Agriculture University, 2016:52 -58(in Chinese)
李佳. Hippo信号通路在调节卵巢生殖干细胞功能和延缓卵巢衰老中的作用[D].南昌:南昌大学, 2016:34-35Li J. The roles of Hippo signaling pathway in regulating the function of ovarian germline stem cells and delaying ovarian aging[D]. Nanchang:Nanchang University, 2016:34 -35(in Chinese)
王兰.线粒体应激对卵子发育潜能及卵巢储备功能的影响[D].武汉:华中科技大学, 2017:42-49Wang L. Impact of mitochondrial stress on oocyte competency and ovarian reserve[D]. Wuhan:Huazhong University of Science and Technology, 2017:42 -49(in Chinese)
Shin K T, Guo J, Niu Y J, et al. The toxic effect of aflatoxin B1 on early porcine embryonic development[J]. Theriogenology, 2018, 118:157-163 Huang C H, Wang F T, Chan W H. Enniatin B1 exerts embryotoxic effects on mouse blastocysts and induces oxidative stress and immunotoxicity during embryo development[J]. Environmental Toxicology, 2019, 34(1):48-59 Wu T S, Lin Y T, Huang Y T, et al. Ochratoxin A triggered intracerebral hemorrhage in embryonic zebrafish:Involvement of microRNA-731 and prolactin receptor[J]. Chemosphere, 2020, 242:125143 Zhang L P, Li L S, Xu J, et al. HT-2 toxin exposure induces mitochondria dysfunction and DNA damage during mouse early embryo development[J]. Reproductive Toxicology, 2019, 85:104-109 Xu Y, Zhang K H, Sun M H, et al. Protective effects of melatonin against zearalenone toxicity on porcine embryos in vitro [J]. Frontiers in Pharmacology, 2019, 10:327 Bondy G S, Coady L, Ross N, et al. A reproductive and developmental screening study of the fungal toxin ochratoxin A in Fischer rats[J]. Mycotoxin Research, 2018, 34(4):241-255 Li R, Andersen C L, Hu L M, et al. Dietary exposure to mycotoxin zearalenone (ZEA) during post-implantation adversely affects placental development in mice[J]. Reproductive Toxicology, 2019, 85:42-50 Zhao X X, Wang D X, Fields P G, et al. Effect of aflatoxin B1 on development, survival and fecundity of Ahasverus advena (Waltl)[J]. Journal of Stored Products Research, 2018, 77:225-230 Yang X, Liu P L, Cui Y L, et al. Review of the reproductive toxicity of T-2 toxin[J]. Journal of Agricultural and Food Chemistry, 2020, 68(3):727-734 Gao X, Xiao Z H, Li C, et al. Prenatal exposure to zearalenone disrupts reproductive potential and development via hormone-related genes in male rats[J]. Food and Chemical Toxicology, 2018, 116:11-19 Zhou Y W, Zhang D, Sun D H, et al. Zearalenone affects reproductive functions of male offspring via transgenerational cytotoxicity on spermatogonia in mouse[J]. Comparative Biochemistry and Physiology Toxicology&Pharmacology, 2020, 234:108766 史雅凝.鸡蛋膜蛋白酶解物的制备及其对肠道氧化应激和炎症的影响[D].无锡:江南大学, 2015:26-34Shi Y N. Preparation of soluble eggshell membrane hydrolysate and its anti-oxidaitve stress and anti-inflammatory effects[D]. Wuxi:Jiangnan University, 2015:26 -34(in Chinese)
Wu J, Yang C L, Liu J, et al. Betulinic acid attenuates T-2-toxin-induced testis oxidative damage through regulation of the JAK2/STAT3 signaling pathway in mice[J]. Biomolecules, 2019, 9(12):E787 Huang C H, Wang F T, Chan W H. Prevention of ochratoxin A-induced oxidative stress-mediated apoptotic processes and impairment of embryonic development in mouse blastocysts by liquiritigenin[J]. Environmental Toxicology, 2019, 34(5):573-584 Szabó B, Kocsis R, Mézes M. Reproduction inhibiting effects of deoxynivalenol or T-2 toxin contaminated maize on Folsomia candida (Collembola)[J]. Acta Zoologica Academiae Scientiarum Hungaricae, 2019, 65(4):323-334 Xu Y, Zhang K H, Sun M H, et al. Protective effects of melatonin against zearalenone toxicity on porcine embryos in vitro [J]. Frontiers in Pharmacology, 2019, 10:327 Huang W Y, Cao Z, Zhang J, et al. Aflatoxin B1 promotes autophagy associated with oxidative stress-related PI3K/AKT/mTOR signaling pathway in mice testis[J]. Environmental Pollution, 2019, 255(Pt 2):113317 Cao Z, Shao B, Xu F B, et al. Protective effect of selenium on aflatoxin B1-induced testicular toxicity in mice[J]. Biological Trace Element Research, 2017, 180(2):233-238 Huang W Y, Cao Z, Yao Q C, et al. Mitochondrial damage are involved in aflatoxin B1-induced testicular damage and spermatogenesis disorder in mice[J]. The Science of the Total Environment, 2020, 701:135077 Omur A D, Yildirim B, Saglam Y S, et al. Activity of resveratrol on the influence of aflatoxin B1 on the testes of Sprague Dawley rats[J]. Polish Journal of Veterinary Sciences, 2019, 22(2):313-320 Huang W Y, Liu M L, Xiao B N, et al. Aflatoxin B1 disrupts blood-testis barrier integrity by reducing junction protein and promoting apoptosis in mice testes[J]. Food and Chemical Toxicology, 2021, 148:111972 Zamir-Nasta T, Pazhouhi M, Ghanbari A, et al. Expression of cyclin D1, p21, and estrogen receptor alpha in aflatoxin G1-induced disturbance in testicular tissue of albino mice[J]. Research in Pharmaceutical Sciences, 2021, 16(2):182-192 del Fabbro L, Jesse C R, de Gomes M G, et al. The flavonoid chrysin protects against zearalenone induced reproductive toxicity in male mice[J]. Toxicon, 2019, 165:13-21 Long M, Yang S H, Zhang Y, et al. Proanthocyanidin protects against acute zearalenone-induced testicular oxidative damage in male mice[J]. Environmental Science and Pollution Research International, 2017, 24(1):938-946 Long M, Yang S H, Wang Y, et al. The protective effect of selenium on chronic zearalenone-induced reproductive system damage in male mice[J]. Molecules, 2016, 21(12):E1687 杨振东.模式生物秀丽隐杆线虫评价真菌毒素毒性毒理机制的研究[D].无锡:江南大学, 2016:61-69Yang Z D. Study of mycotoxins toxic effects and mechanisms using a model organism nematode Caenorhabdites elegans [D]. Wuxi:Jiangnan University, 2016:61 -69(in Chinese)
Zhu Y F, Wang H, Wang J P, et al. Zearalenone induces apoptosis and cytoprotective autophagy in chicken granulosa cells by PI3K-AKT-mTOR and MAPK signaling pathways[J]. Toxins, 2021, 13(3):199 Park H, Park H S, Lim W, et al. Ochratoxin A suppresses proliferation of Sertoli and Leydig cells in mice[J]. Medical Mycology, 2020, 58(1):71-82 Akpinar H A, Kahraman H, Yaman I. Ochratoxin A sequentially activates autophagy and the ubiquitin-proteasome system[J]. Toxins, 2019, 11(11):615 Zhang T Y, Kong L, Hao J X, et al. Effects of ochratoxin A exposure on DNA damage in porcine granulosa cells in vitro [J]. Toxicology Letters, 2020, 330:167-175 Zhang T Y, Sun X F, Li L, et al. Ochratoxin A exposure impairs porcine granulosa cell growth via the PI3K/AKT signaling pathway[J]. Journal of Agricultural and Food Chemistry, 2019, 67(9):2679-2690 Zhang T Y, Wu R Y, Zhao Y, et al. Ochratoxin A exposure decreased sperm motility via the AMPK and PTEN signaling pathways[J]. Toxicology and Applied Pharmacology, 2018, 340:49-57 Wu T S, Cheng Y C, Chen P J, et al. Exposure to aflatoxin B1 interferes with locomotion and neural development in zebrafish embryos and larvae[J]. Chemosphere, 2019, 217:905-913 Karaman E F, Zeybel M, Ozden S. Evaluation of the epigenetic alterations and gene expression levels of HepG2 cells exposed to zearalenone and α -zearalenol[J]. Toxicology Letters, 2020, 326:52-60 Zhu C C, Hou Y J, Han J, et al. Effect of mycotoxin-containing diets on epigenetic modifications of mouse oocytes by fluorescence microscopy analysis[J]. Microscopy and Microanalysis, 2014, 20(4):1158-1166 Song Y, Yang L. Transgenerational impaired spermatogenesis with sperm H19 and Gtl2 hypomethylation induced by the endocrine disruptor p,p'-DDE[J]. Toxicology Letters, 2018, 297:34-41 -
点击查看大图
计量
- 文章访问数: 1995
- HTML全文浏览数: 1995
- PDF下载数: 59
- 施引文献: 0
下载:
