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环境污染物诱导神经毒性的表观遗传机制研究进展

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李富萍, 黄清育. 环境污染物诱导神经毒性的表观遗传机制研究进展[J]. 生态毒理学报, 2023, 18(1): 1-15. doi: 10.7524/AJE.1673-5897.20220914003
引用本文: 李富萍, 黄清育. 环境污染物诱导神经毒性的表观遗传机制研究进展[J]. 生态毒理学报, 2023, 18(1): 1-15. doi: 10.7524/AJE.1673-5897.20220914003
shu
Li Fuping, Huang Qingyu. Research Progress on Epigenetic Mechanism of Neurotoxicity Induced by Environmental Pollutants[J]. Asian journal of ecotoxicology, 2023, 18(1): 1-15. doi: 10.7524/AJE.1673-5897.20220914003
Citation: Li Fuping, Huang Qingyu. Research Progress on Epigenetic Mechanism of Neurotoxicity Induced by Environmental Pollutants[J]. Asian journal of ecotoxicology, 2023, 18(1): 1-15. doi: 10.7524/AJE.1673-5897.20220914003
shu

环境污染物诱导神经毒性的表观遗传机制研究进展

  • 1. 中国科学院城市环境研究所, 中国科学院城市环境与健康重点实验室, 厦门 361021;

  • 2. 中国科学院大学, 北京 100049;

  • 3. 福建农林大学生命科学学院, 福州 350028

    • 作者简介: 李富萍(1997—)，女，硕士研究生，研究方向为环境毒理学，E-mail:fpli@iue.ac.cn
    通讯作者: 黄清育, E-mail: qyhuang@iue.ac.cn
  • 基金项目:

    国家自然科学基金面上项目(22076179，21677142)；福建省自然科学基金资助项目(2022J06033)；厦门市青年创新基金资助项目(3502Z20206091)

  • 中图分类号: X171.5

Research Progress on Epigenetic Mechanism of Neurotoxicity Induced by Environmental Pollutants

  • 1. Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China;

  • 2. University of Chinese Academy of Sciences, Beijing 100049, China;

  • 3. College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350028, China

    • Corresponding author: Huang Qingyu, qyhuang@iue.ac.cn
  • Fund Project:

  • 摘要: 表观遗传修饰与神经系统功能密切相关，其在环境污染物暴露致神经毒性中的作用机制已引起广泛关注。本文综述了重金属、有机污染物和空气颗粒物等典型环境污染物对人体和模式生物表观遗传修饰(DNA甲基化、组蛋白修饰和ncRNA等)和神经系统功能的影响，指出环境污染物可直接或(通过引起氧化胁迫)间接改变表观遗传修饰状态，导致相关基因表达失调，从而诱导一系列神经毒性，并提出当前研究存在的局限性。建议未来针对污染物的神经毒性机制研究，应着重关注组蛋白修饰和ncRNA以及不同类型表观遗传修饰之间的交互作用；同时，环境污染物复合暴露导致神经毒性的表观遗传机制有待深入研究；如何从表观遗传角度解释环境污染物诱导神经毒性的年龄易感性及性别特异性也值得进一步探讨。
    Abstract: Studies have shown that environmental pollutants can enter the human body directly through drinking water, breathing, dermal contact or indirectly through the food chain, and can pose adverse effects on the central nervous system. Epigenetic modifications are closely related to the function of the nervous system, and their role in the neurotoxicity induced by environmental pollutant exposure has attracted much attention. This paper reviews the effects of typical environmental pollutants, such as heavy metals, organic pollutants and air particulate matters, on epigenetic modifications (DNA methylation, histone modifications, and ncRNAs) and neurological functions in humans and model organisms, and suggests that environmental pollutants can directly or indirectly (by causing oxidative stress) alter the status of epigenetic modifications, leading to dysregulation of relevant gene expression and thus inducing a series of neurotoxicity, such as neuronal apoptosis, learning and memory deficits and neurodegenerative diseases. The limitations of the current studies are also presented. It is suggested that future research on the neurotoxicity mechanisms of pollutants should pay more attention to histone modifications and ncRNAs, as well as the corsstalk between different epigenetic modifications. In addition, the epigenetic mechanisms involved in the neurotoxicity induced by combined exposure of various pollutants and the age susceptibility and sex specificity of neurotoxicity also deserve further investigation.
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  • 收稿日期:  2022-09-14
李富萍, 黄清育. 环境污染物诱导神经毒性的表观遗传机制研究进展[J]. 生态毒理学报, 2023, 18(1): 1-15. doi: 10.7524/AJE.1673-5897.20220914003
引用本文: 李富萍, 黄清育. 环境污染物诱导神经毒性的表观遗传机制研究进展[J]. 生态毒理学报, 2023, 18(1): 1-15. doi: 10.7524/AJE.1673-5897.20220914003
shu
Li Fuping, Huang Qingyu. Research Progress on Epigenetic Mechanism of Neurotoxicity Induced by Environmental Pollutants[J]. Asian journal of ecotoxicology, 2023, 18(1): 1-15. doi: 10.7524/AJE.1673-5897.20220914003
Citation: Li Fuping, Huang Qingyu. Research Progress on Epigenetic Mechanism of Neurotoxicity Induced by Environmental Pollutants[J]. Asian journal of ecotoxicology, 2023, 18(1): 1-15. doi: 10.7524/AJE.1673-5897.20220914003
shu

环境污染物诱导神经毒性的表观遗传机制研究进展

    通讯作者: 黄清育, E-mail: qyhuang@iue.ac.cn
    作者简介: 李富萍(1997—)，女，硕士研究生，研究方向为环境毒理学，E-mail:fpli@iue.ac.cn
  • 1. 中国科学院城市环境研究所, 中国科学院城市环境与健康重点实验室, 厦门 361021;
  • 2. 中国科学院大学, 北京 100049;
  • 3. 福建农林大学生命科学学院, 福州 350028
  • 收稿日期:  2022-09-14
基金项目:

国家自然科学基金面上项目(22076179，21677142)；福建省自然科学基金资助项目(2022J06033)；厦门市青年创新基金资助项目(3502Z20206091)

摘要: 表观遗传修饰与神经系统功能密切相关，其在环境污染物暴露致神经毒性中的作用机制已引起广泛关注。本文综述了重金属、有机污染物和空气颗粒物等典型环境污染物对人体和模式生物表观遗传修饰(DNA甲基化、组蛋白修饰和ncRNA等)和神经系统功能的影响，指出环境污染物可直接或(通过引起氧化胁迫)间接改变表观遗传修饰状态，导致相关基因表达失调，从而诱导一系列神经毒性，并提出当前研究存在的局限性。建议未来针对污染物的神经毒性机制研究，应着重关注组蛋白修饰和ncRNA以及不同类型表观遗传修饰之间的交互作用；同时，环境污染物复合暴露导致神经毒性的表观遗传机制有待深入研究；如何从表观遗传角度解释环境污染物诱导神经毒性的年龄易感性及性别特异性也值得进一步探讨。

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