双酚类化合物污染现状和内分泌干扰效应研究进展
Advances on Pollution Status and Endocrine Disrupting Effects of Bisphenols
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摘要: 双酚类化合物(bisphenols,BPs)是合成碳酸聚酯、环氧树脂和聚丙烯酸酯等高分子聚合物的主要原料，在商业制造中广泛使用。经过度排放污染环境，并能通过食物链放大作用在动物和人体内蓄积。已经在水体、底泥、室内灰尘、食品以及动物和人体内检测到双酚A (bisphenol A,BPA)及其替代品或衍生物等多种BPs。BPs对性激素、甲状腺素和神经内分泌系统具有干扰效应，能影响机体生殖功能、性腺发育、神经行为和激素依赖性疾病的发展，已经成为危害人体健康的风险因子。多种BPA替代品的内分泌干扰效应甚至比BPA更强，但缺乏全面的内分泌干扰效应评估数据和对作用机制的深入研究。本文对BPs种类来源、污染现状及其内分泌干扰效应进行综述。Abstract: Bisphenols (BPs) are widely used as the primary raw materials for synthesizing polyester carbonate, epoxy resin, and polyacrylate to manufacture high molecular polymers. After being excessively discharged, BPs pollute the environment and accumulate in animals and humans bodies via the biomagnification of the food chain. So far, various BPs have been detected in water, sediment, indoor dust, food, as well as the animal and human body, including bisphenol A (BPA) and its multiple substitutes and derivatives. It has been reported that BPs interfere with gonadal hormone endocrine, thyroxine endocrine, and neuroendocrine, which can further affect reproductive function, gonadal development, neurobehavior, and hormone-dependent diseases. Therefore, BPs have become risk factors that endanger human health. The endocrine-disrupting effects of BPA substitutes are even more potent than that of BPA, and comprehensive endocrine-disrupting effects and underlying mechanisms require to be further studied. Here we summarize the state of the current knowledge about the sources, pollution status, and endocrine-disrupting effects of BPs.
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Key words:
- bisphenols /
- pollution status /
- endocrine-disrupting effects
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Kavlock R J, Daston G P, DeRosa C, et al. Research needs for the risk assessment of health and environmental effects of endocrine disruptors:A report of the US EPA-sponsored workshop[J]. Environmental Health Perspectives, 1996, 104(Suppl. 4):715-740 Welshons W V, Nagel S C, vom Saal F S. Large effects from small exposures. Ⅲ. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure[J]. Endocrinology, 2006, 147(6):s56-s69 Chen D, Kannan K, Tan H L, et al. Bisphenol analogues other than BPA:Environmental occurrence, human exposure, and toxicity:A review[J]. Environmental Science&Technology, 2016, 50(11):5438-5453 Lee H R, Jeung E B, Cho M H, et al. Molecular mechanism (s) of endocrine-disrupting chemicals and their potent oestrogenicity in diverse cells and tissues that express oestrogen receptors[J]. Journal of Cellular and Molecular Medicine, 2013, 17(1):1-11 Costa E M F, Spritzer P M, Hohl A, et al. Effects of endocrine disruptors in the development of the female reproductive tract[J]. Arquivos Brasileiros de Endocrinologia e Metabologia, 2014, 58(2):153-161 National Toxicology Program (NTP). NTP Research Report on the CLARITY-BPA core study:A perinatal and chronic extended-dose-range study of bisphenol A in rats[R]. Washington DC:National Institute of Environmental Health Sciences, 2018 Willhite C C, Daston G P. Bisphenol exposure, hazard and regulation[J]. Toxicology, 2019, 425:152243 石珏.双酚A暴露方式对线虫生长生殖发育及凋亡的影响[D].合肥:中国科学技术大学, 2018:1-4Shi J. Effects of bisphenol A on the growth, reproductive development and apoptosis in Caenorhabditis elegans under different exposure ways[D]. Hefei:University of Science and Technology of China, 2018:1 -4(in Chinese)
梁栋.双酚类化合物的环境雌激素效应研究[D].北京:中国科学院大学, 2014:11 Usman A, Ikhlas S, Ahmad M. Occurrence, toxicity and endocrine disrupting potential of bisphenol-B and bisphenol-F:A mini-review[J]. Toxicology Letters, 2019, 312:222-227 Cunha S C, Fernandes J O. Quantification of free and total bisphenol A and bisphenol B in human urine by dispersive liquid-liquid microextraction (DLLME) and heart-cutting multidimensional gas chromatography-mass spectrometry (MD-GC/MS)[J]. Talanta, 2010, 83(1):117-125 Alabi A, Caballero-Casero N, Rubio S. Quick and simple sample treatment for multiresidue analysis of bisphenols, bisphenol diglycidyl ethers and their derivatives in canned food prior to liquid chromatography and fluorescence detection[J]. Journal of Chromatography A, 2014, 1336:23-33 Cunha S C, Almeida C, Mendes E, et al. Simultaneous determination of bisphenol A and bisphenol B in beverages and powdered infant formula by dispersive liquid-liquid micro-extraction and heart-cutting multidimensional gas chromatography-mass spectrometry[J]. Food Additives&Contaminants:Part A, 2011, 28(4):513-526 Cunha S C, Cunha C, Ferreira A R, et al. Determination of bisphenol A and bisphenol B in canned seafood combining QuEChERS extraction with dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2012, 404(8):2453-2463 Grumetto L, Gennari O, Montesano D, et al. Determination of five bisphenols in commercial milk samples by liquid chromatography coupled to fluorescence detection[J]. Journal of Food Protection, 2013, 76(9):1590-1596 Kuruto-Niwa R, Nozawa R, Miyakoshi T, et al. Estrogenic activity of alkylphenols, bisphenol S, and their chlorinated derivatives using a GFP expression system[J]. Environmental Toxicology and Pharmacology, 2005, 19(1):121-130 Simoneau C, Valzacchi S, Morkunas V, et al. Comparison of migration from polyethersulphone and polycarbonate baby bottles[J]. Food Additives&Contaminants:Part A, 2011, 28(12):1763-1768 Wu L H, Zhang X M, Wang F, et al. Occurrence of bisphenol S in the environment and implications for human exposure:A short review[J]. Science of the Total Environment, 2018, 615:87-98 Lu S Y, Yu Y L, Ren L, et al. Estimation of intake and uptake of bisphenols and triclosan from personal care products by dermal contact[J]. Science of the Total Environment, 2018, 621:1389-1396 Rochester J R, Bolden A L. Bisphenol S and F:A systematic review and comparison of the hormonal activity of bisphenol A substitutes[J]. Environmental Health Perspectives, 2015, 123(7):643-650 Lee S, Liao C Y, Song G J, et al. Emission of bisphenol analogues including bisphenol A and bisphenol F from wastewater treatment plants in Korea[J]. Chemosphere, 2015, 119:1000-1006 Ji K, Choi K. Endocrine disruption potentials of bisphenol A alternatives:are bisphenol A alternatives safe from endocrine disruption?[J]. Korean Journal of Environmental Health Sciences, 2013, 39(1):1-18 Yu X H, Xue J C, Yao H, et al. Occurrence and estrogenic potency of eight bisphenol analogs in sewage sludge from the US EPA targeted national sewage sludge survey[J]. Journal of Hazardous Materials, 2015, 299:733-739 Im J, L ffler F E. Fate of bisphenol A in terrestrial and aquatic environments[J]. Environmental Science&Technology, 2016, 50(16):8403-8416 Jin H B, Zhu L Y. Occurrence and partitioning of bisphenol analogues in water and sediment from Liaohe River Basin and Taihu Lake, China[J]. Water Research, 2016, 103:343-351 Wan Y J, Xia W, Yang S Y, et al. Spatial distribution of bisphenol S in surface water and human serum from Yangtze River watershed, China:Implications for exposure through drinking water[J]. Chemosphere, 2018, 199:595-602 Si W, Cai Y F, Liu J C, et al. Investigating the role of colloids on the distribution of bisphenol analogues in surface water from an ecological demonstration area, China[J]. Science of the Total Environment, 2019, 673:699-707 Zhang H F, Zhang Y P, Li J B, et al. Occurrence and exposure assessment of bisphenol analogues in source water and drinking water in China[J]. Science of the Total Environment, 2019, 655:607-613 Liu Y H, Zhang S H, Song N H, et al. Occurrence, distribution and sources of bisphenol analogues in a shallow Chinese freshwater lake (Taihu Lake):Implications for ecological and human health risk[J]. Science of the Total Environment, 2017, 599-600:1090-1098 Wang Y X, Liu C, Shen Y, et al. Urinary levels of bisphenol A, F and S and markers of oxidative stress among healthy adult men:Variability and association analysis[J]. Environment International, 2019, 123:301-309 Zheng C Y, Liu J C, Ren J H, et al. Occurrence, distribution and ecological risk of bisphenol analogues in the surface water from a water diversion project in Nanjing, China[J]. International Journal of Environmental Research and Public Health, 2019, 16(18):3296 Yamazaki E, Yamashita N, Taniyasu S, et al. Bisphenol A and other bisphenol analogues including BPS and BPF in surface water samples from Japan, China, Korea and India[J]. Ecotoxicology and Environmental Safety, 2015, 122:565-572 Schmidt N, Castro-Jiménez J, Fauvelle V, et al. Occurrence of organic plastic additives in surface waters of the Rhône River (France)[J]. Environmental Pollution, 2020, 257:113637 Liao C Y, Liu F, Moon H B, et al. Bisphenol analogues in sediments from industrialized areas in the United States, Japan, and Korea:Spatial and temporal distributions[J]. Environmental Science&Technology, 2012, 46(21):11558-11565 Yang Y J, Lu L B, Zhang J, et al. Simultaneous determination of seven bisphenols in environmental water and solid samples by liquid chromatography-electrospray tandem mass spectrometry[J]. Journal of Chromatography A, 2014, 1328:26-34 Wang W, Abualnaja K O, Asimakopoulos A G, et al. A comparative assessment of human exposure to tetrabromobisphenol A and eight bisphenols including bisphenol A via indoor dust ingestion in twelve countries[J]. Environment International, 2015, 83:183-191 Song S J, Ruan T, Wang T, et al. Distribution and preliminary exposure assessment of bisphenol AF (BPAF) in various environmental matrices around a manufacturing plant in China[J]. Environmental Science&Technology, 2012, 46(24):13136-13143 Ye X Y, Wong L Y, Kramer J, et al. Urinary concentrations of bisphenol A and three other bisphenols in convenience samples of US adults during 2000-2014[J]. Environmental Science&Technology, 2015, 49(19):11834-11839 Liao C Y, Liu F, Alomirah H, et al. Bisphenol S in urine from the United States and seven Asian countries:Occurrence and human exposures[J]. Environmental Science&Technology, 2012, 46(12):6860-6866 Liu Y H, Yan Z Y, Zhang Q, et al. Urinary levels, composition profile and cumulative risk of bisphenols in preschool-aged children from Nanjing suburb, China[J]. Ecotoxicology and Environmental Safety, 2019, 172:444-450 Xue J C, Wu Q, Sakthivel S, et al. Urinary levels of endocrine-disrupting chemicals, including bisphenols, bisphenol A diglycidyl ethers, benzophenones, parabens, and triclosan in obese and non-obese Indian children[J]. Environmental Research, 2015, 137:120-128 Asimakopoulos A G, Xue J C, de Carvalho B P, et al. Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia[J]. Environmental Research, 2016, 150:573-581 Deceuninck Y, Bichon E, Marchand P, et al. Determination of bisphenol A and related substitutes/analogues in human breast milk using gas chromatography-tandem mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2015, 407(9):2485-2497 Liu J Y, Li J G, Wu Y N, et al. Bisphenol A metabolites and bisphenol S in paired maternal and cord serum[J]. Environmental Science&Technology, 2017, 51(4):2456-2463 Zhou J, Xu J J, Cong J M, et al. Optimization for quick, easy, cheap, effective, rugged and safe extraction of mycotoxins and veterinary drugs by response surface methodology for application to egg and milk[J]. Journal of Chromatography A, 2018, 1532:20-29 Zhou J, Chen X H, Pan S D, et al. Contamination status of bisphenol A and its analogues (bisphenol S, F and B) in foodstuffs and the implications for dietary exposure on adult residents in Zhejiang Province[J]. Food Chemistry, 2019, 294:160-170 Zhou Q H, Jin Z H, Li J, et al. A novel air-assisted liquid-liquid microextraction based on in situ phase separation for the HPLC determination of bisphenols migration from disposable lunch boxes to contacting water[J]. Talanta, 2018, 189:116-121 Covaci A, Hond E D, Geens T, et al. Urinary BPA measurements in children and mothers from six European member states:Overall results and determinants of exposure[J]. Environmental Research, 2015, 141:77-85 Hartle J C, Navas-Acien A, Lawrence R S. The consumption of canned food and beverages and urinary bisphenol A concentrations in NHANES 2003-2008[J]. Environmental Research, 2016, 150:375-382 Cao X L, Perez-Locas C, Robichaud A, et al. Levels and temporal trend of bisphenol A in composite food samples from Canadian Total Diet Study 2008-2012[J]. Food Additives&Contaminants:Part A, 2015, 32(12):2154-2160 Liu J Y, Wattar N, Field C J, et al. Exposure and dietary sources of bisphenol A (BPA) and BPA-alternatives among mothers in the APrON cohort study[J]. Environment International, 2018, 119:319-326 Xiong L, Yan P, Chu M, et al. A rapid and simple HPLC-FLD screening method with QuEChERS as the sample treatment for the simultaneous monitoring of nine bisphenols in milk[J]. Food Chemistry, 2018, 244:371-377 Cunha S C, Oliveira C, Fernandes J O. Development of QuEChERS-based extraction and liquid chromatography-tandem mass spectrometry method for simultaneous quantification of bisphenol A and tetrabromobisphenol A in seafood:Fish, bivalves, and seaweeds[J]. Analytical and Bioanalytical Chemistry, 2017, 409(1):151-160 Zhang H, Quan Q, Zhang M Y, et al. Occurrence of bisphenol A and its alternatives in paired urine and indoor dust from Chinese university students:Implications for human exposure[J]. Chemosphere, 2020, 247:125987 Thayer K A, Taylor K W, Garantziotis S, et al. Bisphenol A, bisphenol S, and 4-hydroxyphenyl 4-isopro oxyphenyl sulfone (BPSIP) in urine and blood of cashiers[J]. Environmental Health Perspectives, 2016, 124(4):437-444 González N, Cunha S C, Monteiro C, et al. Quantification of eight bisphenol analogues in blood and urine samples of workers in a hazardous waste incinerator[J]. Environmental Research, 2019, 176:108576 Song S M, Duan Y S, Zhang T, et al. Serum concentrations of bisphenol A and its alternatives in elderly population living around e-waste recycling facilities in China:Associations with fasting blood glucose[J]. Ecotoxicology and Environmental Safety, 2019, 169:822-828 Mu X Y, Huang Y, Li X X, et al. Developmental effects and estrogenicity of bisphenol A alternatives in a zebrafish embryo model[J]. Environmental Science&Technology, 2018, 52(5):3222-3231 Lee J Y, Kim S, Choi K, et al. Effects of bisphenol analogs on thyroid endocrine system and possible interaction with 17β -estradiol using GH3 cells[J]. Toxicology in Vitro, 2018, 53:107-113 Ullah A, Pirzada M, Jahan S, et al. Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S:Comparative in vitro and in vivo studies on the sperms and testicular tissues of rats[J]. Chemosphere, 2018, 209:508-516 Ji K, Hong S, Kho Y, et al. Effects of bisphenol S exposure on endocrine functions and reproduction of zebrafish[J]. Environmental Science&Technology, 2013, 47(15):8793-8800 Pollock T, Greville L J, Weaver R E, et al. Bisphenol S modulates concentrations of bisphenol A and oestradiol in female and male mice[J]. Xenobiotica, 2019, 49(5):540-548 Berni M, Gigante P, Bussolati S, et al. Bisphenol S, a bisphenol A alternative, impairs swine ovarian and adipose cell functions[J]. Domestic Animal Endocrinology, 2019, 66:48-56 Campen K A, Lavallee M, Combelles C. The impact of bisphenol S on bovine granulosa and theca cells[J]. Reproduction in Domestic Animals, 2018, 53(2):450-457 Gingrich J, Pu Y, Roberts J, et al. Gestational bisphenol S impairs placental endocrine function and the fusogenic trophoblast signaling pathway[J]. Archives of Toxicology, 2018, 92(5):1861-1876 Yang Q, Yang X H, Liu J N, et al. Exposure to bisphenol B disrupts steroid hormone homeostasis and gene expression in the hypothalamic-pituitary-gonadal axis of zebrafish[J]. Water, Air,&Soil Pollution, 2017, 228(3):1-12 Yang X X, Liu Y C, Li J, et al. Exposure to bisphenol AF disrupts sex hormone levels and vitellogenin expression in zebrafish[J]. Environmental Toxicology, 2016, 31(3):285-294 Jones R L, Lang S A, Kendziorski J A, et al. Use of a mouse model of experimentally induced endometriosis to evaluate and compare the effects of bisphenol A and bisphenol AF exposure[J]. Environmental Health Perspectives, 2018, 126(12):127004 Zhang Z B, Hu Y, Guo J L, et al. Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice[J]. Nature Communications, 2017, 8:14585 Wang T, Han J, Duan X, et al. The toxic effects and possible mechanisms of bisphenol A on oocyte maturation of porcine in vitro [J]. Oncotarget, 2016, 7(22):32554-32565 Li Y, Luh C J, Burns K A, et al. Endocrine-disrupting chemicals (EDCs): in vitro mechanism of estrogenic activation and differential effects on ER target genes[J]. Environmental Health Perspectives, 2013, 121(4):459-466 Li Y, Burns K A, Arao Y, et al. Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitro [J]. Environmental Health Perspectives, 2012, 120(7):1029-1035 Conley J M, Hannas B R, Furr J R, et al. A demonstration of the uncertainty in predicting the estrogenic activity of individual chemicals and mixtures from an in vitro estrogen receptor transcriptional activation assay (T47D-KBluc) to the in vivo uterotrophic assay using oral exposure[J]. Toxicological Sciences, 2016, 153(2):382-395 Mesnage R, Phedonos A, Arno M, et al. Editor's Highlight:Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells[J]. Toxicological Sciences:An Official Journal of the Society of Toxicology, 2017, 158(2):431-443 Kojima H, Takeuchi S, Sanoh S, et al. Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors[J]. Toxicology, 2019, 413:48-55 Le Fol V, At-Assa S, Sonavane M, et al. In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays[J]. Ecotoxicology and Environmental Safety, 2017, 142:150-156 Molina-Molina J M, Amaya E, Grimaldi M, et al. In vitro study on the agonistic and antagonistic activities of bisphenol-S and other bisphenol-A congeners and derivatives via nuclear receptors[J]. Toxicology and Applied Pharmacology, 2013, 272(1):127-136 Kang J S, Choi J S, Kim W K, et al. Estrogenic potency of bisphenol S, polyethersulfone and their metabolites generated by the rat liver S9 fractions on a MVLN cell using a luciferase reporter gene assay[J]. Reproductive Biology and Endocrinology, 2014, 12:102 Cano-Nicolau J, Vaillant C, Pellegrini E, et al. Estrogenic effects of several BPA analogs in the developing zebrafish brain[J]. Frontiers in Neuroscience, 2016, 10:112 Moreman J, Lee O, Trznadel M, et al. Acute toxicity, teratogenic, and estrogenic effects of bisphenol A and its alternative replacements bisphenol S, bisphenol F, and bisphenol AF in zebrafish embryo-larvae[J]. Environmental Science&Technology, 2017, 51(21):12796-12805 Feng Y X, Yin J, Jiao Z H, et al. Bisphenol AF may cause testosterone reduction by directly affecting testis function in adult male rats[J]. Toxicology Letters, 2012, 211(2):201-209 Li J, Sheng N, Cui R N, et al. Gestational and lactational exposure to bisphenol AF in maternal rats increases testosterone levels in 23-day-old male offspring[J]. Chemosphere, 2016, 163:552-561 Ullah A, Pirzada M, Jahan S, et al. Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats:A focus on the possible hormonal mode of action[J]. Food and Chemical Toxicology, 2018, 121:24-36 Teng C, Goodwin B, Shockley K, et al. Bisphenol A affects androgen receptor function via multiple mechanisms[J]. Chemico-Biological Interactions, 2013, 203(3):556-564 Rosenmai A K, Dybdahl M, Pedersen M, et al. Are structural analogues to bisphenol A safe alternatives?[J]. Toxicological Sciences, 2014, 139(1):35-47 Tang T L, Yang Y, Chen Y W, et al. Thyroid disruption in zebrafish larvae by short-term exposure to bisphenol AF[J]. International Journal of Environmental Research and Public Health, 2015, 12(10):13069-13084 Kwon B, Kho Y, Kim P G, et al. Thyroid endocrine disruption in male zebrafish following exposure to binary mixture of bisphenol AF and sulfamethoxazole[J]. Environmental Toxicology and Pharmacology, 2016, 48:168-174 Huang G M, Tian X F, Fang X D, et al. Waterborne exposure to bisphenol F causes thyroid endocrine disruption in zebrafish larvae[J]. Chemosphere, 2016, 147:188-194 Zhang Y F, Ren X M, Li Y Y, et al. Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo [J]. Environmental Pollution, 2018, 237:1072-1079 Lu L P, Zhan T J, Ma M, et al. Thyroid disruption by bisphenol S analogues via thyroid hormone receptor β :in vitro, in vivo , and molecular dynamics simulation study[J]. Environmental Science&Technology, 2018, 52(11):6617-6625 Lei B, Xu J, Peng W, et al. In vitro profiling of toxicity and endocrine disrupting effects of bisphenol analogues by employing MCF-7 cells and two-hybrid yeast bioassay[J]. Environmental Toxicology, 2017, 32(1):278-289 Kinch C D, Ibhazehiebo K, Jeong J H, et al. Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish[J]. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112(5):1475-1480 Qiu W H, Zhao Y L, Yang M, et al. Actions of bisphenol A and bisphenol S on the reproductive neuroendocrine system during early development in zebrafish[J]. Endocrinology, 2016, 157(2):636-647 Mi P, Zhang Q P, Zhang S H, et al. The effects of fluorene-9-bisphenol on female zebrafish (Danio rerio) reproductive and exploratory behaviors[J]. Chemosphere, 2019, 228:398-411 Gong M, Huai Z Q, Song H, et al. Effects of maternal exposure to bisphenol AF on emotional behaviors in adolescent mice offspring[J]. Chemosphere, 2017, 187:140-146 Ji X M, Shi L L, Yin X, et al. Sex-and developmental stage-dependent effects of fluorene-9-bisphenol exposure on emotional behaviors in mice[J]. Chemosphere, 2019, 225:890-896 Kolatorova L, Vitku J, Hampl R, et al. Exposure to bisphenols and parabens during pregnancy and relations to steroid changes[J]. Environmental Research, 2018, 163:115-122 Castro B, Sánchez P, Torres J M, et al. Bisphenol A, bisphenol F and bisphenol S affect differently 5α-reductase expression and dopamine-serotonin systems in the prefrontal cortex of juvenile female rats[J]. Environmental Research, 2015, 142:281-287 -
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