环境浓度抗生素引起斑马鱼焦虑/抑郁样行为与“肠-脑”途径关联的研究进展
Research Progress on Association between Anxiety/Depression-like Behavior and “Gut-Brain” Axis in Zebrafish Induced by Environmental Concentrations of Antibiotics
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摘要: 抗生素在环境中广泛被检出，对动物和人类造成潜在不良影响。抗生素能够改变斑马鱼肠道菌群组成和丰度，进而引起斑马鱼焦虑/抑郁样行为。本文对有关抗生素残留的报道进行了总结，概括分析了抗生素对斑马鱼焦虑/抑郁样行为与斑马鱼肠道菌群的关联。主要从高级神经系统途径、神经内分泌途径、免疫途径、肠道菌群代谢途径和氧化应激途径探讨了抗生素引起斑马鱼焦虑/抑郁样行为变化与“肠-脑”途径作用的关联机制。本文为抗生素和斑马鱼神经行为变化机制研究提供一定的参考。Abstract: Antibiotics are widely detected in the environment, causing potential adverse effects on animals and humans. Antibiotics can change the composition and abundance of intestinal microflora in zebrafish, thereby causing anxiety/depression-like behavior. In this paper, reports on antibiotic residues were summarized, and the association between antibiotics on anxiety/depression-like behavior and intestinal microflora in zebrafish was summarized and analyzed. This paper mainly discusses the correlation mechanism between anxiety/depression-like behavior changes and the “gut-brain” axis of zebrafish induced by antibiotics from the aspects of higher nervous system pathway, neuroendocrine pathway, immune pathway, intestinal flora metabolic pathway and oxidative stress pathway. This review provides some references for the study of antibiotics and the mechanism of neurobehavioral changes in zebrafish.
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Key words:
- antibiotics /
- zebrafish /
- anxiety/depression-like behavior /
- “gut-brain” axis
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