典型北方城市河流中抗生素污染特征及风险评价
Pollution Characteristics and Risk Assessment of Antibiotics in Typical Northern Urban Rivers
-
摘要: 本研究对北方某市2条河流中磺胺类、喹诺酮类和β-内酰胺类的10种典型抗生素进行了污染特征分析和生态风险评估。结果表明，滏阳河与沁河水中分别检出8种和7种抗生素，浓度范围为ND～205 ng·L-1和ND～152 ng·L-1，检出率与平均含量最高的为磺胺类，其次为喹诺酮类、β-内酰胺类；沉积物中分别检出7种和6种抗生素，检出浓度范围分别为ND～57.0 ng·g-1和ND～36.6 ng·g-1。检出率最高的为喹诺酮类的环丙沙星、诺氟沙星，磺胺类居中，洛美沙星检出率最低，氟罗沙星仅在滏阳河中检出。β-内酰胺类3种抗生素未在沉积物中检出；抗生素在时空分布上呈现冬季高于夏季、滏阳河高于沁河、出市断面高于入市断面的特征。与南方地区相比北方河流中磺胺类和喹诺酮类抗生素含量较高。通过物种敏感度分布（SSD）法得到的风险评估结果低于传统的单一物种风险评估法，但2种评估结果均表明洛美沙星存在较高的生态风险，有关北方地区城市河流中抗生素污染问题应得到重视。Abstract: In this present study, 10 typical antibiotics in two rivers in a northern city were analyzed to obtain the pollution characteristics and ecological risk assessment, including sulfonamides, quinolones and β-lactam antibiotics. The results revealed that 8 kinds of antibiotics and 7 kinds of antibiotics were detected in Fuyang River and Qin River, respectively, with the concentration range of ND~205 ng·L-1 and ND~152 ng·L-1, respectively. The detection rate and average content of sulfonamide antibiotics were the highest, followed by quinolones and β-lactams. A total of 7 and 6 antibiotics were detected in sediments, with the detection concentration range of ND~57.0 ng·g-1 and ND~36.6 ng·g-1. The quinolone ciprofloxacin and norfloxacin had the highest detection rate, the sulfonamides were in the middle, and lomefloxacin had the lowest detection rate. Fleroxacin was only detected in Fuyang River. The three types of β-lactam antibiotics were not detected in the sediments. The temporal and spatial distribution of antibiotics was higher in winter than that in summer. Fuyang River was higher than Qin River, and the exit section was higher than the entry section. The contents of sulfonamides and quinolone antibiotics in northern rivers were higher than that in southern regions. The risk assessment results obtained by the species sensitivity distribution method were lower than that obtained by the traditional single species risk assessment method. However, both assessments indicated that lomefloxacin had a higher ecological risk. Most importantly, the issues of antibiotic pollution in urban rivers in northern regions should be given more attention.
-
Key words:
- antibiotics /
- urban rivers in the north /
- pollution characteristics /
- risk assessment
-
-
Böger B, Surek M, Vilhena R O, et al. Occurrence of antibiotics and antibiotic resistant bacteria in subtropical urban rivers in Brazil[J]. Journal of Hazardous Materials, 2021, 402:123448 Valdés M E, Santos L H M L M, Rodríguez Castro M C, et al. Distribution of antibiotics in water, sediments and biofilm in an urban river (Córdoba, Argentina, LA)[J]. Environmental Pollution, 2021, 269:116133 Da Le N, Hoang A Q, Hoang T T H, et al. Antibiotic and antiparasitic residues in surface water of urban rivers in the Red River Delta (Hanoi, Vietnam):Concentrations, profiles, source estimation, and risk assessment[J]. Environmental Science and Pollution Research International, 2021, 28(9):10622-10632 Alder A, McArdell C, Golet E, et al. Occurrence and fate of fluoroquinolone, macrolide, and sulfonamide antibiotics during wastewater treatment and in ambient waters in Switzerland[J]. ACS Symposium Series, 2001, 791:56-69 Lindsey M E, Meyer T M, Thurman E M. Analysis of trace levels of sulfonamide and tetracycline antimicrobials in groundwater and surface water using solid-phase extraction and liquid chromatography/mass spectrometry[J]. Analytical Chemistry, 2001, 73(19):4640-4646 赵富强, 高会, 张克玉, 等. 中国典型河流水域抗生素的赋存状况及风险评估研究[J]. 环境污染与防治, 2021, 43(1):94-102 Zhao F Q, Gao H, Zhang K Y, et al. Occurrence and risk assessment of antibiotics in typical river basins in China[J]. Environmental Pollution & Control, 2021, 43(1):94-102(in Chinese)
Peng Q C, Song J M, Li X G, et al. Biogeochemical characteristics and ecological risk assessment of pharmaceutically active compounds (PhACs) in the surface seawaters of Jiaozhou Bay, North China[J]. Environmental Pollution, 2019, 255(Pt 1):113247 Ding H J, Wu Y X, Zhang W H, et al. Occurrence, distribution, and risk assessment of antibiotics in the surface water of Poyang Lake, the largest freshwater lake in China[J]. Chemosphere, 2017, 184:137-147 张慧, 郭文建, 刘绍丽, 等. 南四湖和东平湖表层水体中抗生素污染特征和风险评价[J]. 环境化学, 2020, 39(12):3279-3287 Zhang H, Guo W J, Liu S L, et al. Contamination characteristics and risk assessment of antibiotics in surface water of Nansi Lake and Dongping Lake[J]. Environmental Chemistry, 2020, 39(12):3279-3287(in Chinese)
Carvalho I T, Santos L. Antibiotics in the aquatic environments:A review of the European scenario[J]. Environment International, 2016, 94:736-757 高俊敏, 舒心, 侯先宇, 等. 村镇尺度水土环境中抗生素的污染特征及源解析[EB/OL]. (2021-07-07)[2021-09-17]. https://doi.org/10.19674/j.cnki.issn1000-6923.20210706.015 王娅南, 彭洁, 黄合田, 等. 贵阳市城市河流典型抗生素的分布特征[J]. 环境化学, 2018, 37(9):2039-2048 Wang Y N, Peng J, Huang H T, et al. Distribution characteristics of typical antibiotics in urban rivers of Guiyang City[J]. Environmental Chemistry, 2018, 37(9):2039-2048(in Chinese)
Wang G G, Zhou S H, Han X K, et al. Occurrence, distribution, and source track of antibiotics and antibiotic resistance genes in the main rivers of Chongqing City, Southwest China[J]. Journal of Hazardous Materials, 2020, 389:122110 Jiang L, Hu X L, Yin D Q, et al. Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai, China[J]. Chemosphere, 2011, 82(6):822-828 Li Y, Zhang L Y, Liu X S, et al. Ranking and prioritizing pharmaceuticals in the aquatic environment of China[J]. The Science of the Total Environment, 2019, 658:333-342 Qiu W H, Sun J, Fang M J, et al. Occurrence of antibiotics in the main rivers of Shenzhen, China:Association with antibiotic resistance genes and microbial community[J]. The Science of the Total Environment, 2019, 653:334-341 申立娜, 张璐璐, 秦珊, 等. 白洋淀喹诺酮类抗生素污染特征及其与环境因子相关性研究[J]. 环境科学学报, 2019, 39(11):3888-3897 Shen L N, Zhang L L, Qin S, et al. The occurrence and distribution of quinolones (QNs) and correlation analysis between QNs and physical-chemical parameters in Baiyangdian Lake, North China[J]. Acta Scientiae Circumstantiae, 2019, 39(11):3888-3897(in Chinese)
颦楚. 2019中国医药企业品牌影响力排行榜[J]. 互联网周刊, 2019(23):44-47 Pin C. 2019 Chinese pharmaceutical enterprise brand influence ranking[J]. China Internet Week, 2019(23):44-47(in Chinese)
张旭, 王雅静, 赵志强, 等. 华北地区部分河流中典型抗生素的分布特征及来源分析[J]. 环境监测管理与技术, 2020, 32(5):14-17 Zhang X, Wang Y J, Zhao Z Q, et al. Distribution characteristics and source analysis of typical antibiotics in some rivers in North China[J]. The Administration and Technique of Environmental Monitoring, 2020, 32(5):14-17(in Chinese)
李清雪, 孙王茹, 汪庆. SPE-HPLC测定水中β-内酰胺类、喹诺酮类、磺胺类抗生素[J]. 中国给水排水, 2019, 35(18):118-122 Li Q X, Sun W R, Wang Q. Determination of β-lactams, quinolones and sulfonamides antibiotics in water by SPE-HPLC[J]. China Water & Wastewater, 2019, 35(18):118-122(in Chinese)
Guérit I, Bocquené G, James A, et al. Environmental risk assessment:A critical approach of the European TGD in an in situ application[J]. Ecotoxicology and Environmental Safety, 2008, 71(1):291-300 Hernando M D, Mezcua M, Fernández-Alba A R, et al. Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments[J]. Talanta, 2006, 69(2):334-342 Eguchi K, Nagase H, Ozawa M, et al. Evaluation of antimicrobial agents for veterinary use in the ecotoxicity test using microalgae[J]. Chemosphere, 2004, 57(11):1733-1738 Ferrari B, Mons R, Vollat B, et al. Environmental risk assessment of six human pharmaceuticals:Are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?[J]. Environmental Toxicology and Chemistry, 2004, 23(5):1344-1354 Holten Lützhøft H, Halling-Sørensen B, Jørgensen S E. Algal toxicity of antibacterial agents applied in Danish fish farming[J]. Archives of Environmental Contamination and Toxicology, 1999, 36(1):1-6 Robinson A A, Belden J B, Lydy M J. Toxicity of fluoroquinolone antibiotics to aquatic organisms[J]. Environmental Toxicology and Chemistry, 2005, 24(2):423 Backhaus T, Scholze M, Grimme L H. The single substance and mixture toxicity of quinolones to the bioluminescent bacterium Vibrio fischeri[J]. Aquatic Toxicology, 2000, 49(1-2):49-61 Le Page G, Gunnarsson L, Trznadel M, et al. Variability in cyanobacteria sensitivity to antibiotics and implications for environmental risk assessment[J]. The Science of the Total Environment, 2019, 695:133804 United States Environmental Protection Agency (US EPA). Guidelines for deriving numerical national water quality criteria for the protection of aquatic organisms and their uses[R]. Washington DC:US EPA, 1985 United States Environmental Protection Agency (US EPA). Guidelines for ecological risk assessment. EPA/630/R-95/002F[R]. Washington DC:US EPA, 1998 梁峰. 我国典型流域重金属的风险评价及六价铬水质基准的推导[D]. 南京:南京大学, 2011:11-12 Liang F. The ecological risk assessment of heavy metals and the derivation of water quality criteria of hexavalent chromium for typical basins in China[D]. Nanjing:Nanjing University, 2011:11 -12(in Chinese)
汪涛, 杨再福, 陈勇航, 等. 地表水中磺胺类抗生素的生态风险评价[J]. 生态环境学报, 2016, 25(9):1508-1514 Wang T, Yang Z F, Chen Y H, et al. Ecological risk assessment for sulfonamides in surface waters[J]. Ecology and Environmental Sciences, 2016, 25(9):1508-1514(in Chinese)
梁霞, 周军英, 李建宏, 等. 物种敏感度分布法(SSD)在农药水质基准推导中的应用[J]. 生态与农村环境学报, 2015, 31(3):398-405 Liang X, Zhou J Y, Li J H, et al. Application of species sensitivity distribution (SSD) to derivation of water quality criteria for pesticides[J]. Journal of Ecology and Rural Environment, 2015, 31(3):398-405(in Chinese)
Canadian Council of Ministers of the Environment (CCME). A protocol for the derivation of water quality guidelines for the protection of aquatic life[R]. Winnipeg, Manitoba:CCME, 1999 Canadian Council of Ministers of the Environment (CCME). A protocol for the derivation of water quality guidelines for the protection of aquatic life. Canadian environmental quality guidelines[R]. Ottawa:CCME, 2007 National Institute of Public Health and the Environment (RIVM). Guidance document on deriving environmental risk limits in the Netherlands. Report No. 601501012[R]. Bilthoven:RIVM, 2001 陈莹, 赵晓光. 西安市典型河流中4种抗生素的生态风险评价[J]. 环境污染与防治, 2021, 43(5):626-630 Chen Y, Zhao X G. Ecological risk assessment of four antibiotics in typical rivers of Xi'an[J]. Environmental Pollution & Control, 2021, 43(5):626-630(in Chinese)
Borecka M, Białk-Bielińska A, Haliński Ł P, et al. The influence of salinity on the toxicity of selected sulfonamides and trimethoprim towards the green algae Chlorella vulgaris[J]. Journal of Hazardous Materials, 2016, 308:179-186 王作铭, 陈军, 陈静, 等. 地表水中抗生素复合残留对水生生物的毒性及其生态风险评价[J]. 生态毒理学报, 2018, 13(4):149-160 Wang Z M, Chen J, Chen J, et al. Toxicity to aquatic organisms and ecological risk assessment of antibiotic compound residues in the surface water[J]. Asian Journal of Ecotoxicology, 2018, 13(4):149-160(in Chinese)
赵业, 唐永政, 李秉钧, 等. 四种典型抗生素对刺参幼参的急性毒性研究[J]. 海洋湖沼通报, 2019(2):132-138 Zhao Y, Tang Y Z, Li B J, et al. Acute toxic effects of four typical antibiotics on juvenile of sea cucumber[J]. Transactions of Oceanology and Limnology, 2019 (2):132-138(in Chinese)
刘仁彬, 姜锦林, 张宇峰, 等. 磺胺甲恶唑对斑马鱼胚胎/仔鱼的毒性效应[J]. 环境污染与防治, 2020, 42(3):310-316 Liu R B, Jiang J L, Zhang Y F, et al. Toxic effects of sulfamethoxazole on zebrafish (Danio rerio) embryo/larva[J]. Environmental Pollution & Control, 2020, 42(3):310-316(in Chinese)
聂湘平, 王翔, 陈菊芳, 等. 三氯异氰尿酸与盐酸环丙沙星对蛋白核小球藻的毒性效应[J]. 环境科学学报, 2007, 27(10):1694-1701 Nie X P, Wang X, Chen J F, et al. Toxic effects of trichloroisocyanuric acid and ciprofloxacin hydrochloride on a freshwater alga, Chlorella pyrenoidosa[J]. Acta Scientiae Circumstantiae, 2007, 27(10):1694-1701(in Chinese)
连鹏, 葛利云, 邓欢欢, 等. 两种喹诺酮类抗生素对亚心形扁藻的毒性效应研究[J]. 环境科学与管理, 2014, 39(5):46-48 Lian P, Ge L Y, Deng H H, et al. Toxic effects of two quinolone antibiotics on Platymonas subcordiformis[J]. Environmental Science and Management, 2014, 39(5):46-48(in Chinese)
FASS. FASS Allmanhet-Startsida[EB/OL]. (2018-12-04)[2021-10-07]. https://www.fass.se/LIF/startpage/ 房英春, 齐跃, 李莹, 等. 盐酸环丙沙星、恩诺沙星和诺氟沙星对孔雀鱼急性毒性试验研究[J]. 沈阳大学学报:自然科学版, 2012, 24(3):15-17 Fang Y C, Qi Y, Li Y, et al. Acute toxicity experience to guppy with ciprofloxacin HCl, enrofloxacin and norfloxacin[J]. Journal of Shenyang University:Natural Science, 2012, 24(3):15-17(in Chinese)
施文杰, 王长友, 杨锐. 诺氟沙星对盐生杜氏藻、新月菱形藻和小球藻的生态毒性效应[J]. 海洋环境科学, 2019, 38(1):1-6 Shi W J, Wang C Y, Yang R. Effects of norfloxacin on Dunaliella salina, Nitzschia closterium f. minutissima and Chlorella vulgaris[J]. Marine Environmental Science, 2019, 38(1):1-6(in Chinese)
鹿金雁. 叔丁基对羟基茴香醚和诺氟沙星对水生生物的毒性效应[D]. 广州:暨南大学, 2007:1 Lu J Y. Toxic effects of butylated hydroxyanisole and norfloxacin to aquatic organsims[D]. Guangzhou:Jinan University, 2007:1(in Chinese) 汪皓琦, 董玉瑛, 汪灵伟, 等. 4种喹诺酮类抗生素对发光菌毒性作用研究[J]. 生态毒理学报, 2017, 12(3):453-459 Wang H Q, Dong Y Y, Wang L W, et al. The toxicity of four quinolones to Photobacterium phosphoreum[J]. Asian Journal of Ecotoxicology, 2017, 12(3):453-459(in Chinese)
蔡梦婷, 侯国权, 奚豪, 等. 典型抗生素与重金属铜复合暴露对淡水绿藻和斑马鱼的联合毒性[J]. 浙江树人大学学报:自然科学版, 2018(2):11-15 Cai M T, Hou G Q, Xi H, et al. Combined toxicity of co-exposure of typical antibiotic and heavy metal copper on freshwater green algae and zebrafish[J]. Journal of Zhejiang Shuren University:Natural Science Edition, 2018 (2):11-15(in Chinese)
Pfizer Inc. Pfizer-Lomefloxacin Hydrochloride Tablets. Material safety data sheet[EB/OL]. (2018-12-20)[2021-11-11]. http://www.pfizer.com Zheng S L, Qiu X Y, Chen B, et al. Antibiotics pollution in Jiulong River Estuary:Source, distribution and bacterial resistance[J]. Chemosphere, 2011, 84(11):1677-1685 Boreen A L, Arnold W A, McNeill K. Photochemical fate of sulfa drugs in the aquatic environment:Sulfa drugs containing five-membered heterocyclic groups[J]. Environmental Science & Technology, 2004, 38(14):3933-3940 Li W H, Shi Y L, Gao L H, et al. Occurrence and removal of antibiotics in a municipal wastewater reclamation plant in Beijing, China[J]. Chemosphere, 2013, 92(4):435-444 Hou J P, Poole J W. β-lactam antibiotics:Their physicochemical properties and biological activities in relation to structure[J]. Journal of Pharmaceutical Sciences, 1971, 60(4):503-532 Liu X H, Lu S Y, Guo W, et al. Antibiotics in the aquatic environments:A review of lakes, China[J]. The Science of the Total Environment, 2018, 627:1195-1208 Zhang J Q, Dong Y H. Effect of low-molecular-weight organic acids on the adsorption of norfloxacin in typical variable charge soils of China[J]. Journal of Hazardous Materials, 2008, 151(2-3):833-839 王正文. 邯郸市滏阳河综合治理初探[J]. 价值工程, 2011, 30(19):317 Wang Z W. Exploration on comprehensive treatment of Fuyang River in Handan City[J]. Value Engineering, 2011 , 30(19):317(in Chinese)
Guo X Y, Feng C H, Zhang J H, et al. Role of dams in the phase transfer of antibiotics in an urban river receiving wastewater treatment plant effluent[J]. The Science of the Total Environment, 2017, 607-608:1173-1179 杨宇轩, 徐瑞皎, 冯启言, 等. 3种喹诺酮类抗生素在骆马湖饮用水源地沉积物上的吸附特征[J]. 环境污染与防治, 2020, 42(6):717-722 Yang Y X, Xu R J, Feng Q Y, et al. Adsorption characteristics of three quinolone antibiotics on sediment from drinking water source of Luoma Lake[J]. Environmental Pollution & Control, 2020, 42(6):717-722(in Chinese)
吴天宇, 李江, 杨爱江, 等. 赤水河流域水体抗生素污染特征及风险评价[J]. 环境科学, 2022, 43(1):210-219 Wu T Y, Li J, Yang A J, et al. Characteristics and risk assessment of antibiotic contamination in Chishui River Basin, Guizhou Province, China[J]. Environmental Science, 2022, 43(1):210-219(in Chinese)
周志洪, 赵建亮, 魏晓东, 等. 珠江广州段水体抗生素的复合污染特征及其生态风险[J]. 生态环境学报, 2017, 26(6):1034-1041 Zhou Z H, Zhao J L, Wei X D, et al. Co-occurrence and ecological risk of antibiotics in surface water of Guangzhou section of Pearl River[J]. Ecology and Environmental Sciences, 2017, 26(6):1034-1041(in Chinese)
Selvam A, Kwok K, Chen Y M, et al. Influence of livestock activities on residue antibiotic levels of rivers in Hong Kong[J]. Environmental Science and Pollution Research International, 2017, 24(10):9058-9066 Gothwal R, Shashidhar. Occurrence of high levels of fluoroquinolones in aquatic environment due to effluent discharges from bulk drug manufacturers[J]. Journal of Hazardous, Toxic, and Radioactive Waste, 2017, 21(3):1-8 Jank L, Hoff R B, Costa F J D, et al. Simultaneous determination of eight antibiotics from distinct classes in surface and wastewater samples by solid-phase extraction and high-performance liquid chromatography-electrospray ionisation mass spectrometry[J]. International Journal of Environmental Analytical Chemistry, 2014, 94(10):1013-1037 Nakata H, Kannan K, Jones P D, et al. Determination of fluoroquinolone antibiotics in wastewater effluents by liquid chromatography-mass spectrometry and fluorescence detection[J]. Chemosphere, 2005, 58(6):759-766 栗萍. 邯郸市畜禽养殖业污染现状及减排措施分析[J]. 中国农业信息, 2013(7):144 崔建新, 刘玉荣, 赵小凤, 等. 5种喹诺酮类药急性毒性实验[J]. 中国医院药学杂志, 2001, 21(11):680 Cui J X, Liu Y R, Zhao X F, et al. Acute toxicity experiment of five quinolones[J]. Chinese Journal of Hospital Pharmacy, 2001 , 21(11):680(in Chinese)
顾玉英, 邓湘平. 喹诺酮类药物的光毒性反应及原因分析[J]. 现代医药卫生, 2005, 21(19):2610 Forbes V E, Calow P. Species sensitivity distributions revisited:A critical appraisal[J]. Human and Ecological Risk Assessment:An International Journal, 2002, 8(3):473-492 蔡立红, 阮姝楠, 郭晓红. 180例喹诺酮类药品的不良反应临床分析[J]. 中国临床药理学杂志, 2016, 32(8):736-737 Cai L H, Ruan S N, Guo X H. Clinical analysis on 180 cases of quinolone drugs on adverse drug reactions[J]. The Chinese Journal of Clinical Pharmacology, 2016, 32(8):736-737(in Chinese)
-
点击查看大图
计量
- 文章访问数: 2165
- HTML全文浏览数: 2165
- PDF下载数: 58
- 施引文献: 0
下载:
