生物对得克隆物种特异性立体异构体选择性富集及其潜在机理
Species-specific Stereo-selective Enrichment of DP in Organisms and Their Possible Mechanisms
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摘要: 得克隆(dechlorane plus,DP)是一种氯代添加型阻燃剂,自2006年首次在环境中被报道检出后,在全球各种环境和生物介质中被检出,已成为广受关注的一类新环境污染物。DP的工业品由2种同分异构体(syn-DP和anti-DP)组成,生物中DP的组成与工业品的组成并不完全一致。笔者总结了DP在生物中富集的文献。现有文献有关DP的生物富集研究主要集中在鱼、鸟及部分哺乳动物。鱼类中普遍观察到syn-DP的相对富集,部分鸟类样品中观察到anti-DP的相对富集。大量文献将生物中DP的组成与工业品DP的组成直接比较来判定是否存在生物对DP的立体异构体选择性富集,忽视了环境与生物过程对DP组成的改变,因此,DP在生物中的立体异构体选择性富集情形可能被低估。室内暴露实验揭示选择性代谢与排泄是造成DP在生物中选择性富集的主要原因,但具体的代谢、排泄的机理目前并不明晰。DP在生物中的立体异构体选择性富集还受生物组织、体内浓度、生物所处的营养级和性别等众多因素的影响。要了解DP生物富集中的立体选择性富集机理,还需要进一步深入研究DP在不同生物中的吸收、代谢及与生物大分子之间的相互作用。Abstract: Dechlorane plus (DP) is an additive chlorinated flame retardant. Since it was found in sediment and fish in Great Lakes in 2006, DP had been detected in the environmental matrix and biota samples around the world and it has become an emerging pollutant. The commercial products of DP are mixture of two stereo isomers:syn-DP and anti-DP. The compositions of DP in the biota samples are not always the same as those in the commercial products. This paper presents a review of the bioaccumulation of DP in biota samples. The studies on bioaccumulation of DP mainly focus on fish, birds, and some mammals. Stereoselective enrichment of syn-DP was widely observed in fish whereas selective enrichment of anti-DP was mainly found in some birds. A direct comparison in DP composition between biota sample and the commercial product was used to determine whether or not a stereoselective enrichment of DP occurred, which will underestimate the potential stereoselective enrichment of DP in organisms because the composition of DP changed after being released into the environment. Selectively metabolism or excretion of one isomer was the cause for observed stereoselective bioaccumulation of DP but the details of the mechanism are not clear yet. The tissue or organs of organisms, concentration of DP, trophic levels occupied by the organisms, and sex can all affect the composition of DP in organisms. To get a better understanding of the species-specific stereoselective enrichment of DP, more studies on absorption, elimination, and metabolism of DP in more species and on interactions between DP and biomacromolecule are needed.
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Key words:
- dechlorane plus /
- bioaccumulation /
- stereoselective enrichment /
- species-specific
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罗孝俊,麦碧娴.新型持久性有机污染物的生物富集[M].北京:科学出版社, 2017:254-255 Hoh E, Zhu L Y, Hites R A. Dechlorane plus, a chlorinated flame retardant, in the great lakes[J]. Environmental Science&Technology, 2006, 40(4):1184-1189 Wu B, Liu S, Guo X C, et al. Responses of mouse liver to dechlorane plus exposure by integrative transcriptomic and metabonomic studies[J]. Environmental Science&Technology, 2012, 46(19):10758-10764 张刘俊.得克隆对赤子爱胜蚓的毒性效应研究[D].南京:南京大学, 2014:17-22Zhang L J. Comprehensive toxicity study of dechlorane plus on the earthworm Eisenia fetida [D]. Nanjing:Nanjing University, 2014:17 -22(in Chinese)
Zafar M I, Kali S, Ali M, et al. Dechlorane plus as an emerging environmental pollutant in Asia:A review[J]. Environmental Science and Pollution Research International, 2020, 27(34):42369-42389 Wang P, Zhang Q H, Zhang H D, et al. Sources and environmental behaviors of dechlorane plus and related compounds-A review[J]. Environment International, 2016, 88:206-220 Feo M L, Barón E, Eljarrat E, et al. Dechlorane plus and related compounds in aquatic and terrestrial biota:A review[J]. Analytical and Bioanalytical Chemistry, 2012, 404(9):2625-2637 罗孝俊,吴江平,陈社军,等.多溴联苯醚、六溴环十二烷和得克隆的生物差异性富集及其机理研究进展[J].中国科学:化学, 2013, 43(3):291-304 Luo X J, Wu J P, Chen S J, et al. Species-specific bioaccumulation of polybrominated diphenyl ethers, hexabromocyclododecan and dechlorane plus in biota:A review[J]. Scientia Sinica Chimica, 2013, 43(3):291-304(in Chinese)
李宇霖,孟祥周,赵丽芳,等.环境中新兴有机污染物得克隆的研究进展[J].环境科学与技术, 2012, 35(2):79-83 Li Y L, Meng X Z, Zhao L F, et al. Progress on dechlorane plus, an emerging organic pollutant in environment[J]. Environmental Science&Technology, 2012, 35(2):79-83(in Chinese)
Xian Q M, Siddique S, Li T, et al. Sources and environmental behavior of dechlorane plus-A review[J]. Environment International, 2011, 37(7):1273-1284 Sverko E, Tomy G T, Reiner E J, et al. Dechlorane plus and related compounds in the environment:A review[J]. Environmental Science&Technology, 2011, 45(12):5088-5098 Qiu X H, Marvin C H, Hites R A. Dechlorane plus and other flame retardants in a sediment core from Lake Ontario[J]. Environmental Science&Technology, 2007, 41(17):6014-6019 Zhu J P, Feng Y L, Shoeib M. Detection of dechlorane plus in residential indoor dust in the city of Ottawa, Canada[J]. Environmental Science&Technology, 2007, 41(22):7694-7698 Kang J H, Kim J C, Jin G Z, et al. Detection of dechlorane plus in fish from urban-industrial rivers[J]. Chemosphere, 2010, 79(8):850-854 Tomy G T, Pleskach K, Ismail N, et al. Isomers of dechlorane plus in Lake Winnipeg and Lake Ontario food webs[J]. Environmental Science&Technology, 2007, 41(7):2249-2254 Wu J P, Zhang Y, Luo X J, et al. Isomer-specific bioaccumulation and trophic transfer of dechlorane plus in the freshwater food web from a highly contaminated site, South China[J]. Environmental Science&Technology, 2010, 44(2):606-611 Wang D G, Yang M, Qi H, et al. An Asia-specific source of dechlorane plus:Concentration, isomer profiles, and other related compounds[J]. Environmental Science&Technology, 2010, 44(17):6608-6613 M ller A, Xie Z Y, Sturm R, et al. Large-scale distribution of dechlorane plus in air and seawater from the Arctic to Antarctica[J]. Environmental Science&Technology, 2010, 44(23):8977-8982 Zheng J, Wang J, Luo X J, et al. Dechlorane plus in human hair from an e-waste recycling area in South China:Comparison with dust[J]. Environmental Science&Technology, 2010, 44(24):9298-9303 Shen L, Reiner E J, Helm P A, et al. Historic trends of dechloranes 602, 603, 604, dechlorane plus and other norbornene derivatives and their bioaccumulation potential in Lake Ontario[J]. Environmental Science&Technology, 2011, 45(8):3333-3340 Guo J H, Venier M, Salamova A, et al. Bioaccumulation of dechloranes, organophosphate esters, and other flame retardants in Great Lakes fish[J]. The Science of the Total Environment, 2017, 583:1-9 Klosterhaus S L, Stapleton H M, la Guardia M J, et al. Brominated and chlorinated flame retardants in San Francisco Bay sediments and wildlife[J]. Environment International, 2012, 47:56-65 Venier M, Hites R A. Flame retardants in the serum of pet dogs and in their food[J]. Environmental Science&Technology, 2011, 45(10):4602-4608 He M J, Luo X J, Wu J P, et al. Isomers of dechlorane plus in an aquatic environment in a highly industrialized area in Southern China:Spatial and vertical distribution, phase partition, and bioaccumulation[J]. Science of the Total Environment, 2014, 481:1-6 Sun R X, Luo X J, Tang B, et al. Persistent halogenated compounds in fish from rivers in the Pearl River Delta, South China:Geographical pattern and implications for anthropogenic effects on the environment[J]. Environmental Research, 2016, 146:371-378 Zhang X L, Luo X J, Liu H Y, et al. Bioaccumulation of several brominated flame retardants and dechlorane plus in waterbirds from an e-waste recycling region in South China:Associated with trophic level and diet sources[J]. Environmental Science&Technology, 2011, 45(2):400-405 Wu J P, Chen X Y, Si-Kang W, et al. Dechlorane plus flame retardant in a contaminated frog species:Biomagnification and isomer-specific transfer from females to their eggs[J]. Chemosphere, 2018, 211:218-225 Tao W Q, Zhou Z G, Shen L, et al. Determination of dechlorane flame retardants in soil and fish at Guiyu, an electronic waste recycling site in South China[J]. Environmental Pollution, 2015, 206:361-368 Zhang Z W, Tong X, Xing Y, et al. Polybrominated diphenyl ethers, decabromodiphenyl ethane and dechlorane plus in aquatic products from the Yellow River Delta, China[J]. Marine Pollution Bulletin, 2020, 161(Pt A):111733 Wang L, Jia H L, Liu X J, et al. Dechloranes in a river in northeastern China:Spatial trends in multi-matrices and bioaccumulation in fish ( Enchelyopus elongatus )[J]. Ecotoxicology and Environmental Safety, 2012, 84:262-267 Jia H L, Sun Y Q, Liu X J, et al. Concentration and bioaccumulation of dechlorane compounds in coastal environment of Northern China[J]. Environmental Science&Technology, 2011, 45(7):2613-2618 Chen W M, Bao J S, Bu T, et al. Dechlorane plus biomagnification and transmission through prairie food webs in Inner Mongolia, China[J]. Environmental Toxicology and Chemistry, 2021, 40(2):413-421 Kakimoto K, Nagayoshi H, Yoshida J, et al. Detection of dechlorane plus and brominated flame retardants in marketed fish in Japan[J]. Chemosphere, 2012, 89(4):416-419 Zhang H D, Wang P, Li Y M, et al. Assessment on the occupational exposure of manufacturing workers to dechlorane plus through blood and hair analysis[J]. Environmental Science&Technology, 2013, 47(18):10567-10573 Chen W M, Li J Q, Dong Z, et al. Correlations between dechlorane plus concentrations in paired hair and indoor dust samples and differences between dechlorane plus isomer concentrations in hair from males and females[J]. Chemosphere, 2019, 231:378-384 Santín G, Barón E, Eljarrat E, et al. Emerging and historical halogenated flame retardants in fish samples from Iberian rivers[J]. Journal of Hazardous Materials, 2013, 263(Pt 1):116-121 Sühring R, M ller A, Freese M, et al. Brominated flame retardants and dechloranes in eels from German rivers[J]. Chemosphere, 2013, 90(1):118-124 Abdel Malak I, Cariou R, Vénisseau A, et al. Occurrence of dechlorane plus and related compounds in catfish ( Silurus spp.) from rivers in France[J]. Chemosphere, 2018, 207:413-420 Barón E, Giménez J, Verborgh P, et al. Bioaccumulation and biomagnification of classical flame retardants, related halogenated natural compounds and alternative flame retardants in three delphinids from Southern European waters[J]. Environmental Pollution, 2015, 203:107-115 Barón E, Rudolph I, Chiang G, et al. Occurrence and behavior of natural and anthropogenic (emerging and historical) halogenated compounds in marine biota from the Coast of Concepcion (Chile)[J]. Science of the Total Environment, 2013, 461-462:258-264 Na G S, Yao Y, Gao H, et al. Trophic magnification of dechlorane plus in the marine food webs of Fildes Peninsula in Antarctica[J]. Marine Pollution Bulletin, 2017, 117(1-2):456-461 Sühring R, Freese M, Schneider M, et al. Maternal transfer of emerging brominated and chlorinated flame retardants in European eels[J]. The Science of the Total Environment, 2015, 530-531:209-218 Peng H, Zhang K, Wan Y, et al. Tissue distribution, maternal transfer, and age-related accumulation of dechloranes in Chinese sturgeon[J]. Environmental Science&Technology, 2012, 46(18):9907-9913 Muñoz-Arnanz J, Roscales J L, Vicente A, et al. Dechlorane plus in eggs of two gull species ( Larus michahellis and Larus audouinii ) from the southwestern Mediterranean Sea[J]. Analytical and Bioanalytical Chemistry, 2012, 404(9):2765-2773 Kim J T, Son M H, Kang J H, et al. Occurrence of legacy and new persistent organic pollutants in avian tissues from King George Island, Antarctica[J]. Environmental Science&Technology, 2015, 49(22):13628-13638 Kim J T, Choi Y J, Barghi M, et al. Occurrence, distribution, and bioaccumulation of new and legacy persistent organic pollutants in an ecosystem on King George Island, maritime Antarctica[J]. Journal of Hazardous Materials, 2021, 405:124141 Zheng X B, Luo X J, Zeng Y H, et al. Sources, gastrointestinal absorption and stereo-selective and tissue-specific accumulation of dechlorane plus (DP) in chicken[J]. Chemosphere, 2014, 114:241-246 Sun Y X, Luo X J, Wu J P, et al. Species-and tissue-specific accumulation of dechlorane plus in three terrestrial passerine bird species from the Pearl River Delta, South China[J]. Chemosphere, 2012, 89(4):445-451 Sun Y X, Xu X R, Hao Q, et al. Species-specific accumulation of halogenated flame retardants in eggs of terrestrial birds from an ecological station in the Pearl River Delta, South China[J]. Chemosphere, 2014, 95:442-447 Chen K H, Zheng J, Yan X, et al. Dechlorane plus in paired hair and serum samples from e-waste workers:Correlation and differences[J]. Chemosphere, 2015, 123:43-47 Yan X, Zheng J, Chen K H, et al. Dechlorane plus in serum from e-waste recycling workers:Influence of gender and potential isomer-specific metabolism[J]. Environment International, 2012, 49:31-37 Rjabova J, Bartkevics V, Zacs D. The occurrence of dechlorane plus and related norbornene-based flame retardants in Baltic wild salmon ( Salmo salar )[J]. Chemosphere, 2016, 147:210-217 Gauthier L T, Letcher R J. Isomers of dechlorane plus flame retardant in the eggs of herring gulls ( Larus argentatus ) from the Laurentian Great Lakes of North America:Temporal changes and spatial distribution[J]. Chemosphere, 2009, 75(1):115-120 Muñoz-Arnanz J, Sáez M, Hiraldo F, et al. Dechlorane plus and possible degradation products in white stork eggs from Spain[J]. Environment International, 2011, 37(7):1164-1168 Zheng X B, Wu J P, Luo X J, et al. Halogenated flame retardants in home-produced eggs from an electronic waste recycling region in South China:Levels, composition profiles, and human dietary exposure assessment[J]. Environment International, 2012, 45:122-128 Gentes M L, Letcher R J, Caron-Beaudoin É, et al. Novel flame retardants in urban-feeding ring-billed gulls from the St. Lawrence River, Canada[J]. Environmental Science&Technology, 2012, 46(17):9735-9744 Mo L, Wu J P, Luo X J, et al. Dechlorane plus flame retardant in kingfishers ( Alcedo atthis ) from an electronic waste recycling site and a reference site, South China:Influence of residue levels on the isomeric composition[J]. Environmental Pollution, 2013, 174:57-62 Peng Y, Wu J P, Tao L, et al. Accumulation of dechlorane plus flame retardant in terrestrial passerines from a nature reserve in South China:The influences of biological and chemical variables[J]. Science of the Total Environment, 2015, 514:77-82 Chen D, Wang Y, Yu L H, et al. Dechlorane plus flame retardant in terrestrial raptors from Northern China[J]. Environmental Pollution, 2013, 176:80-86 Yu L H, Luo X J, Zheng X B, et al. Occurrence and biomagnification of organohalogen pollutants in two terrestrial predatory food chains[J]. Chemosphere, 2013, 93(3):506-511 Zeng Y H, Luo X J, Tang B, et al. Habitat-and species-dependent accumulation of organohalogen pollutants in home-produced eggs from an electronic waste recycling site in South China:Levels, profiles, and human dietary exposure[J]. Environmental Pollution, 2016, 216:64-70 de la Torre A, Alonso M B, Martínez M A, et al. Dechlorane-related compounds in Franciscana dolphin ( Pontoporia blainvillei ) from southeastern and southern coast of Brazil[J]. Environmental Science&Technology, 2012, 46(22):12364-12372 Ren G F, Yu Z Q, Ma S T, et al. Determination of dechlorane plus in serum from electronics dismantling workers in South China[J]. Environmental Science&Technology, 2009, 43(24):9453-9457 Siddique S, Xian Q M, Abdelouahab N, et al. Levels of dechlorane plus and polybrominated diphenylethers in human milk in two Canadian cities[J]. Environment International, 2012, 39(1):50-55 Brasseur C, Pirard C, Scholl G, et al. Levels of dechloranes and polybrominated diphenyl ethers (PBDEs) in human serum from France[J]. Environment International, 2014, 65:33-40 Zhang Y, Wu J P, Luo X J, et al. Tissue distribution of dechlorane plus and its dechlorinated analogs in contaminated fish:High affinity to the brain for anti-DP[J]. Environmental Pollution, 2011, 159(12):3647-3652 Liu Y, Luo X J, Huang L Q, et al. Halogenated organic pollutants in aquatic, amphibious, and terrestrial organisms from an e-waste site:Habitat-dependent accumulation and maternal transfer in watersnake[J]. Environmental Pollution, 2018, 241:1063-1070 Wang D G, Guo M X, Pei W, et al. Trophic magnification of chlorinated flame retardants and their dechlorinated analogs in a fresh water food web[J]. Chemosphere, 2015, 118:293-300 Tomy G T, Thomas C R, Zidane T M, et al. Examination of isomer specific bioaccumulation parameters and potential in vivo hepatic metabolites of syn-and anti-dechlorane plus isomers in juvenile rainbow trout ( Oncorhynchus mykiss )[J]. Environmental Science&Technology, 2008, 42(15):5562-5567 Zeng Y H, Luo X J, Tang B, et al. Gastrointestinal absorption, dynamic tissue-specific accumulation, and isomer composition of dechlorane plus and related analogs in common carp by dietary exposure[J]. Ecotoxicology and Environmental Safety, 2014, 100:32-38 Tang B, Luo X J, Huang C C, et al. Stereoselective bioaccumulation of syn-and anti-dechlorane plus isomers in different tissues of common carp ( Cyprinus carpio )[J]. The Science of the Total Environment, 2018, 616-617:1339-1346 Li Y, Yu L H, Zhu Z C, et al. Accumulation and effects of 90-day oral exposure to dechlorane plus in quail ( Coturnix coturnix )[J]. Environmental Toxicology and Chemistry, 2013:1649-1654 Li Y, Yu L H, Wang J S, et al. Accumulation pattern of dechlorane plus and associated biological effects on rats after 90 d of exposure[J]. Chemosphere, 2013, 90(7):2149-2156 Li Z R, Luo X J, Luo Y L, et al. Comparative study of dechlorane plus (DP) in adult chickens and developing embryos:Stereo-selective bioaccumulation of DP in chickens[J]. Environmental Pollution, 2019, 247:550-555 Zhao L, Gong N, Mi D, et al. Kinetics of stereoselective enrichment of dechlorane plus in Ulva pertusa [J]. Chemosphere, 2014, 111:580-586 Zhang Y, Luo X J, Mo L, et al. Bioaccumulation and translocation of polyhalogenated compounds in rice ( Oryza sativa L.) planted in paddy soil collected from an electronic waste recycling site, South China[J]. Chemosphere, 2015, 137:25-32 Cheng Y, Ding J, Liang X Y, et al. Fractions transformation and dissipation mechanism of dechlorane plus in the rhizosphere of the soil-plant system[J]. Environmental Science&Technology, 2020, 54(11):6610-6620 Fan Y, Chen S J, Li Q Q, et al. Uptake of halogenated organic compounds (HOCs) into peanut and corn during the whole life cycle grown in an agricultural field[J]. Environmental Pollution, 2020, 263:114400 Chabot-Giguère B, Letcher R J, Verreault J. In vitro biotransformation of decabromodiphenyl ether (BDE-209) and dechlorane plus flame retardants:A case study of ring-billed gull breeding in a pollution hotspot in the St. Lawrence River, Canada[J]. Environment International, 2013, 55:101-108
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